DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16974 and Lingo2

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001101396.1	Gene:	Lingo2 / 313156	RGDID:	1310773	Length:	606	Species:	Rattus norvegicus

Alignment Length:	661	Identity:	151/661 - (22%)
Similarity:	241/661 - (36%)	Gaps:	167/661 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 RLECLHWAIPLAVRRVKVLEMSGNRLSNCSLLNLQYMKQLQELHLDRSELTYLPQRFLGELSELR 278
            ||..:...||:   ..|:|::|.|||.:.:                       |:.|: ....|.
  Rat    47 RLIAIPEGIPI---ETKILDLSKNRLKSIN-----------------------PEEFI-SYPLLE 84

  Fly   279 MLNLSQNLLTELPRDIFVGALKLERLYLSGNRLSVLPFMLFQTAADLQVLDLSDNRLLSFPDNFF 343
            .::||.|::..:....|.....|..|.|.||||.::|..:|...::|..||:|:|:::...|..|
  Rat    85 EIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMF 149

  Fly   344 ARNGQLRQLHLQRNQLKSIGKHSLYSLRELRQLDLSQNSLSVIDRKAFESLDHLLALNVSGNNLT 408
            .....|:.|.:..|.|..|...:...|..|.||.|.:.:|:.:..:|...|..|:.|::...|:.
  Rat   150 QDLHNLKSLEVGDNDLVYISHRAFSGLFSLEQLTLEKCNLTAVPTEALSHLRSLITLHLKHLNIN 214

  Fly   409 LLSSIIFQSLHALRQLDLSR-NQFKQLPS----GLFQRQRSLVLLRIDETPIEQFSNWISRYDES 468
            .:....|:.|..|:||::.. .....:|:    ||.....|:....:...|...|.:
  Rat   215 NMPVYAFKRLFHLKQLEIDYWPLLDMMPANSLYGLNLTSLSITNTNLSTVPFLAFKH-------- 271

  Fly   469 LVDPQVLHRLRYLSVQQNRKLTYLPATLFANTPNIRELLLAENGLLQL-PTQISGLSRLQRLSVR 532
                  |..|.:|::..| .::.:.|.:|::...::||.:....|..: |....||..|:.|:|.
  Rat   272 ------LVYLTHLNLSYN-PISTIEAGMFSDLIRLQELHVVGAQLRTIEPHSFQGLRFLRVLNVS 329

  Fly   533 GNSLGSLPENI-KELRQLHYLNILGNEYQCDCSMYWLTAWLANTST-SLRHQMPQA------QNH 589
            .|.|.:|.||: ...|.|..|:|..|...|||.:.||   |...:| ....|.|..      :..
  Rat   330 QNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWL---LQRQATLQFGGQQPMCAGPDTIRER 391

  Fly   590 SNGSTNQTPLDSYESIDHQIDALKCQYGYRGDMLRVLSKLNCSVPTVVQFSEPKMHKLL----ST 650
            |....:.|.|..|                          ..|..|.:   .|.|:..||    .|
  Rat   392 SFKDFHSTALSFY--------------------------FTCKKPKI---REKKLQHLLVDEGQT 427

  Fly   651 AKLECQISGSPVPDIIWVTPRNKILRHHADPDKRPIIIDSKEDAHQPPSAQELAALMDESYIQSL 715
            .:|||...|.|.|.|.|||||.:.:.
  Rat   428 VQLECNADGDPQPVISWVTPRRRFIT--------------------------------------- 453

  Fly   716 NWTRQNSLVGRRVVLVENGSLLVHNISRIDSGLYTCYAFNVMGK----ASAGLR-------LYID 769
              |:.|   ||..|| .:|:|.:......|||:|.|.|.|..|.    ||..::       ||.:
  Rat   454 --TKSN---GRATVL-GDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFTSDRFLYAN 512

  Fly   770 PIVFYRVKIGSILFGTALATAFL--LLTLIVQGLRSCLSRWGICNRFYCCV---------NRKKK 823
            ....|.......:.....|..|.  |.|::|.....|.:..|:.  .:|.:         .:.|.
  Rat   513 RTPMYMTDSNDTVSNGTNANTFSLDLKTILVSTAMGCFTFLGVV--LFCFLLLFVWSRGKGKHKN 575

  Fly   824 S------PRKH 828
            |      |||:
  Rat   576 SIDLEYVPRKN 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380	4/13 (31%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRR_RI	<246..433	CDD:238064	44/187 (24%)
		LRR_8	251..311	CDD:290566	12/59 (20%)
		leucine-rich repeat	253..276	CDD:275380	2/22 (9%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		LRR_8	325..383	CDD:290566	17/57 (30%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		leucine-rich repeat	349..372	CDD:275380	6/22 (27%)
		LRR_RI	351..>557	CDD:238064	50/212 (24%)
		LRR_8	371..431	CDD:290566	15/60 (25%)
		leucine-rich repeat	373..396	CDD:275380	7/22 (32%)
		leucine-rich repeat	397..420	CDD:275380	5/22 (23%)
		leucine-rich repeat	421..444	CDD:275380	6/27 (22%)
		LRR_8	477..536	CDD:290566	15/59 (25%)
		leucine-rich repeat	478..502	CDD:275380	5/23 (22%)
		leucine-rich repeat	503..526	CDD:275380	6/23 (26%)
		Ig	<714..761	CDD:299845	16/50 (32%)
Lingo2	NP_001101396.1	LRRNT	27..60	CDD:214470	4/15 (27%)
		leucine-rich repeat	39..57	CDD:275380	3/9 (33%)
		leucine-rich repeat	59..82	CDD:275380	8/46 (17%)
		LRR_8	60..117	CDD:404697	18/80 (23%)
		leucine-rich repeat	83..106	CDD:275380	5/22 (23%)
		LRR_8	106..165	CDD:404697	19/58 (33%)
		leucine-rich repeat	107..130	CDD:275380	9/22 (41%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		PPP1R42	176..>373	CDD:411060	53/214 (25%)
		leucine-rich repeat	179..202	CDD:275380	7/22 (32%)
		leucine-rich repeat	203..250	CDD:275380	10/46 (22%)
		leucine-rich repeat	251..274	CDD:275380	4/36 (11%)
		leucine-rich repeat	275..298	CDD:275380	5/23 (22%)
		leucine-rich repeat	299..322	CDD:275380	6/22 (27%)
		leucine-rich repeat	323..343	CDD:275380	8/19 (42%)
		LRRCT	355..408	CDD:214507	14/81 (17%)
		Ig	411..500	CDD:416386	35/136 (26%)
		Ig strand A'	417..421	CDD:409353	0/3 (0%)
		Ig strand B	427..436	CDD:409353	4/8 (50%)
		Ig strand C	441..446	CDD:409353	2/4 (50%)
		Ig strand C'	449..451	CDD:409353	0/1 (0%)
		Ig strand D	460..463	CDD:409353	0/2 (0%)
		Ig strand E	466..473	CDD:409353	2/6 (33%)
		Ig strand F	479..487	CDD:409353	4/7 (57%)
		Ig strand G	490..500	CDD:409353	3/9 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D195414at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010