DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16974 and lron-5

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_497943.2	Gene:	lron-5 / 184307	WormBaseID:	WBGene00008656	Length:	656	Species:	Caenorhabditis elegans

Alignment Length:	596	Identity:	139/596 - (23%)
Similarity:	216/596 - (36%)	Gaps:	193/596 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 CEHVDLRRVNQELLSQRSSHINYNQLMLAHVPADRSNPLKLPQ---------LESLREFSWQSSE 185
            |.|.|...::..::..|.|.:.....||..:.....|.|.|||         |..||.......|
Worm    21 CAHCDCDFISHTVVCNRPSLLIRTVSMLPTIRQLHLNSLNLPQPPHFLFHPNLRVLRMSRCGMHE 85

  Fly   186 LKDETLMELFTRQPRSFEYMERLNLAENRLECLHWAIPLAVRRVKVLEMSGNRLSNCSLLN--LQ 248
            :...|.:.|        ..:|.::|:.|.||.|...:..:::.::||.:|.|||||...|.  |.
Worm    86 IPGSTFLPL--------PGLEVIDLSNNHLETLPPTVLRSLKFLRVLILSNNRLSNLDQLTWILA 142

  Fly   249 YMKQLQELHLD------RSELTYLP---QRFLGELSELRMLNLSQN--LLTELP----RDIFVGA 298
            ....|::|.|.      .:.:|..|   |.|   ||:.||.::::.  :..:||    ||:
Worm   143 PGVVLEQLDLSGNPIAIATSMTVFPPVRQLF---LSDTRMESVNETAIMFKKLPGKCDRDV---- 200

  Fly   299 LKLERLYLSGNRLSVLPFMLFQTAADLQV-------------LDLSDNRL-LSFPD--------- 340
              ...:.:....:|::..:.|.:..||::             :|||:.|| :.|.:
Worm   201 --CRHIPIHNLNVSIITTIDFSSNRDLEIDSGALDVFSNATYVDLSNTRLPVGFEEWLERKSRVK 263

  Fly   341 ---------------------------------------------NFFARNG----------QLR 350
                                                         :.|||:.          .:.
Worm   264 SLNISHCQLPLHEDTWTACGQFLHSLDISGIGAKRLRFSRFCPIRSVFARDNLISSVYIDAVSME 328

  Fly   351 QLHLQRNQLKSI-----GKHSLYSLRELRQLDLSQNSLSVIDRKAFESLDHLLALNVSGNNLTLL 410
            .|||:||.....     |    ..|.||..|.||.|.::.:...|.:|..:|...:||.|.|:.:
Worm   329 SLHLERNMFSEFPIPPPG----VELTELHTLGLSHNLMTSLPPHALQSYPNLQHFDVSSNQLSEI 389

  Fly   411 SSIIFQSLH-ALRQLDLSRNQFKQLPSGLFQRQRSLVLLRIDETPIEQFSNWISRYDESLVDPQV 474
            ....|.|:. .|..||||.||...||..:..   ||:||.:....|            |.:||
Worm   390 DPQAFPSIGLGLISLDLSSNQLSSLPHPILP---SLLLLDLSFNTI------------SHLDP-- 437

  Fly   475 LHRLRYLSVQQNRKLTYLPATLFANTPN---------IRELLLAENGLLQLPTQISGLS------ 524
             |....|.:.|..::...| |||:..||         :.||    ..|:.|....|||.
Worm   438 -HFFTGLPMLQQLRIASNP-TLFSRCPNRDSPCWSDHLDEL----TSLVDLDISNSGLEFSLHWR 496

  Fly   525 ---RLQRLSVRGNSL-----GSLPENIK----------------ELRQLHYLNILGNEYQCDCSM 565
               .|:.|.:|||.:     .|||||::                :|..|..|.:..|..:||||:
Worm   497 HLRTLKSLILRGNEIRIIDSKSLPENLRTLDLGENRVQFTSNFSKLEHLRDLRVDQNPLRCDCSL 561

  Fly   566 YWLTAWLANTS 576
            |.:...|.|.|
Worm   562 YDIVPHLLNQS 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380	6/21 (29%)
		leucine-rich repeat	229..252	CDD:275380	10/24 (42%)
		LRR_RI	<246..433	CDD:238064	58/287 (20%)
		LRR_8	251..311	CDD:290566	15/74 (20%)
		leucine-rich repeat	253..276	CDD:275380	8/31 (26%)
		leucine-rich repeat	277..300	CDD:275380	6/28 (21%)
		leucine-rich repeat	301..324	CDD:275380	2/22 (9%)
		LRR_8	325..383	CDD:290566	23/140 (16%)
		leucine-rich repeat	325..348	CDD:275380	10/100 (10%)
		leucine-rich repeat	349..372	CDD:275380	7/27 (26%)
		LRR_RI	351..>557	CDD:238064	68/250 (27%)
		LRR_8	371..431	CDD:290566	21/60 (35%)
		leucine-rich repeat	373..396	CDD:275380	7/22 (32%)
		leucine-rich repeat	397..420	CDD:275380	7/23 (30%)
		leucine-rich repeat	421..444	CDD:275380	9/22 (41%)
		LRR_8	477..536	CDD:290566	20/76 (26%)
		leucine-rich repeat	478..502	CDD:275380	6/23 (26%)
		leucine-rich repeat	503..526	CDD:275380	7/31 (23%)
		Ig	<714..761	CDD:299845
lron-5	NP_497943.2	leucine-rich repeat	51..72	CDD:275380	5/20 (25%)
		LRR_8	72..131	CDD:338972	16/66 (24%)
		leucine-rich repeat	73..96	CDD:275380	6/30 (20%)
		LRR	<92..>272	CDD:227223	42/196 (21%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..146	CDD:275380	10/24 (42%)
		leucine-rich repeat	147..168	CDD:275380	4/20 (20%)
		leucine-rich repeat	169..208	CDD:275380	10/47 (21%)
		leucine-rich repeat	209..237	CDD:275380	4/27 (15%)
		leucine-rich repeat	238..284	CDD:275380	6/45 (13%)
		leucine-rich repeat	327..351	CDD:275380	7/27 (26%)
		internalin_A	345..>576	CDD:380193	72/255 (28%)
		leucine-rich repeat	352..375	CDD:275380	7/22 (32%)
		leucine-rich repeat	376..391	CDD:275380	5/14 (36%)
		leucine-rich repeat	401..445	CDD:275380	19/61 (31%)
		leucine-rich repeat	446..478	CDD:275380	9/36 (25%)
		leucine-rich repeat	479..500	CDD:275380	5/20 (25%)
		leucine-rich repeat	501..522	CDD:275380	8/20 (40%)
		leucine-rich repeat	523..544	CDD:275380	1/20 (5%)
		LRRCT	553..601	CDD:214507	9/20 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165695
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930