DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16974 and iglr-2

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_498834.1	Gene:	iglr-2 / 176175	WormBaseID:	WBGene00022580	Length:	773	Species:	Caenorhabditis elegans

Alignment Length:	921	Identity:	214/921 - (23%)
Similarity:	364/921 - (39%)	Gaps:	249/921 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 NRLSNCS-LLNLQYMK---------------QLQELHLDRSELTYLPQRFLGELSELRMLNLSQN 285
            ||.|:.| .|:||..|               .:|...:|.|:|..:.:.:...:..|.:.|...:
Worm    23 NRSSSPSGFLDLQLEKCPQVLGCRCVRDSTRNIQCFSIDESKLLEIQKIYGSNIQRLELHNWQHD 87

  Fly   286 LLTELPRDIFVGALKLERLYLSGNRLSVLPFMLFQTAADLQVLDLSDN---------RLLS-FPD 340
               :|..|||....:||.:.|....|..|...:....  |:||.:.::         |||| ||
Worm    88 ---QLNFDIFAPFPQLEHIILRDGDLESLNGTVIHPT--LKVLSIENSELTSSSEVCRLLSIFP- 146

  Fly   341 NFFARNGQLRQLHLQRNQLKSIGKHSLYSLRELRQLDLSQNSLSVIDRKAFESLDHLLALNVSGN 405
                   :::.|.|.:|..:.....:  |..:|:.||||||.:|.:     |..:.|..||||.|
Worm   147 -------KIQSLSLSKNYFEKFECDT--SNTKLKILDLSQNRISHL-----EVPNTLRVLNVSRN 197

  Fly   406 NLTLLSSIIFQSLHALRQLDLSRNQFKQLPS---GLFQRQRSLVLLRID-ETPIEQFSNWISRYD 466
            .||...:|..:    |..||:|.|:....||   ..|...|||..:::| :|..:
Worm   198 RLTSFENISTK----LTDLDISFNKLSLWPSFDDWKFPNLRSLSAIKLDLQTGFQ---------- 248

  Fly   467 ESLVDPQVLH-------RLRYLSVQQ--NRKLTYLPATLFANTPNIRELLLAENGLLQLPTQISG 522
               :|..:|:       .||||:..|  ..||....|.......||..         :||:.::.
Worm   249 ---LDAPLLNSLNIDGASLRYLNFHQILTPKLKKFSARYLTELRNIAG---------RLPSTVTD 301

  Fly   523 LSRLQRLSVRGNSLGSLPENIKELRQLHYLNILG-----NEYQCD-CSMYWLTAWLANTSTSLRH 581
            ::....:      |.:||.:...:...:::..:.     |:..|| |.:.|.....|.||.
Worm   302 VAFTDTM------LRTLPADFIPMSSTNHMQKVSFDFSTNQLLCDKCLLQWSLPVYAQTSI---- 356

  Fly   582 QMPQAQNHSNGSTNQTPLDSYESIDHQIDALKCQYGYRGDMLRVLSKLNCSVPTVVQFSEPKMHK 646
                     ....|.|        ..:|::..|:.|...:            .|.:|:.     |
Worm   357 ---------RKDCNLT--------REEIESASCKIGVVAN------------DTGIQYG-----K 387

  Fly   647 LLSTAKLECQISGSPVPDIIW--VTPRNKILRHHADPDKRPIIIDSKEDAHQPPSAQELAALMDE 709
            ......:.|...|.|.|.|.|  ..|..|:..:  ||....|            |...::..|.|
Worm   388 YEKPTAISCFSYGVPSPKISWWRFRPAEKLGSY--DPITDEI------------SYTNVSETMKE 438

  Fly   710 SY-IQSLNWTRQNSLVGRRVVLVENGSLLVHNISRIDSGLYTCYAFNVMGKASAGLRLYIDPIVF 773
            || |||                  .||||:.:.:|.....|.|...|..||........:|.:.:
Worm   439 SYEIQS------------------GGSLLIRSPNRSHVERYVCVVENEYGKDYGIYHFRLDYLDW 485

  Fly   774 YRVKIGSILFGTALAT-------AFLLLTLIVQGLRSCLSRWGICNRFYCCVNRKKKSPRKHQIY 831
            |...:.:.:|...|||       :|||....:...:|.|  |.|           :::.|..::.
Worm   486 YSYDVFNSVFWGGLATSLIVCLISFLLNITWILTRKSAL--WWI-----------QRAERLSRVR 537

  Fly   832 AMLDSIETYKSQQLERLRENYTQQVHRIRENCAQQVEWIQSSYTSQAKHIREFR----DIGSNHL 892
            .|::::|.|:.:|:|.|.|.||::|..:|:|..||||.::.||.||.:..:.::    |...:||
Worm   538 KMVEAMEKYRVRQMESLHEKYTKRVQIVRDNYHQQVEALRVSYASQQEKFQNYKAAQVDAVHSHL 602

  Fly   893 TTLKDQYYDQVKKVRDYSTGQLSWVRENYVFQRNKIRKFSAHQVLRLREGYKYQQQTLNKVLENL 957
            ..::|.|.:|:.:||:|.:.:...:.|:|..|.|::|.||....|::...||.:|:.:||:||:|
Worm   603 DAMRDGYNNQLGRVREYGSKRAEQLWESYERQVNRMRTFSLQHRLKMMRQYKVKQRYVNKLLESL 667

  Fly   958 ----PSFYFEN-CRGRCEEDIAEDIDCYFKGQMDFGDSKELHIQKIKARLSANYSASKASLYYTP 1017
                |....|| .:.|...:|.:|: ....|.||           ..:||      |::|.:::.
Worm   668 QATSPEVQLENEEKVRAALEIPDDL-ATIDGSMD-----------TPSRL------SRSSSFHSL 714

  Fly  1018 PDDDLLHSSQLNLQNSPIHINYIDENLDQQKQLEHDFKMEPQLLLYNASMLYM--NPEGASSSGQ 1080
            |:                   |:   :|:|.      .:.|.::..||..:..  .|..:|.|.:
Worm   715 PE-------------------YV---IDEQG------NVRPGIIPTNAPSIRFTTKPTTSSISNE 751

  Fly  1081 A--AALAAAGA 1089
            |  ::.:::||
Worm   752 ASTSSPSSSGA 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380	8/30 (27%)
		LRR_RI	<246..433	CDD:238064	54/211 (26%)
		LRR_8	251..311	CDD:290566	14/74 (19%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		LRR_8	325..383	CDD:290566	20/67 (30%)
		leucine-rich repeat	325..348	CDD:275380	9/32 (28%)
		leucine-rich repeat	349..372	CDD:275380	4/22 (18%)
		LRR_RI	351..>557	CDD:238064	52/223 (23%)
		LRR_8	371..431	CDD:290566	23/59 (39%)
		leucine-rich repeat	373..396	CDD:275380	9/22 (41%)
		leucine-rich repeat	397..420	CDD:275380	9/22 (41%)
		leucine-rich repeat	421..444	CDD:275380	8/25 (32%)
		LRR_8	477..536	CDD:290566	12/60 (20%)
		leucine-rich repeat	478..502	CDD:275380	8/25 (32%)
		leucine-rich repeat	503..526	CDD:275380	3/22 (14%)
		Ig	<714..761	CDD:299845	11/46 (24%)
iglr-2	NP_498834.1	leucine-rich repeat	76..99	CDD:275380	6/25 (24%)
		leucine-rich repeat	100..121	CDD:275380	5/20 (25%)
		LRR_RI	<120..>223	CDD:238064	36/123 (29%)
		leucine-rich repeat	122..147	CDD:275380	9/32 (28%)
		leucine-rich repeat	148..169	CDD:275380	4/22 (18%)
		LRR_8	168..219	CDD:290566	23/59 (39%)
		LRR_4	168..206	CDD:289563	17/42 (40%)
		Ig	394..472	CDD:143165	28/109 (26%)
		Apolipoprotein	550..687	CDD:279749	46/136 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I3354
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto18400
orthoMCL	1	0.900	-	-		OOG6_115583
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17035
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.890