DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16974 and Igfals

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001351825.1	Gene:	Igfals / 16005	MGIID:	107973	Length:	638	Species:	Mus musculus

Alignment Length:	509	Identity:	143/509 - (28%)
Similarity:	208/509 - (40%)	Gaps:	119/509 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 SDLDDS--DSDEGLWLDAADAGSESVEVEEHELPSVGHVDPTGNVFKLNCEHVDLRRVN-QELLS 144
            :.|.||  .|...||||..:..|         :||....:.:...| ||.:...||.:. |.||.
Mouse   101 TQLPDSIPVSTRALWLDGNNLSS---------IPSAAFQNLSSLDF-LNLQGSWLRSLEPQALLG 155

  Fly   145 QRS---SHINYNQL------MLAHVPADRSNPLKLPQLESLRE-------------FSWQSSELK 187
            .::   .|:..|.|      :..|.|:..|..|....|..|.|             ..|.|..:.
Mouse   156 LQNLYHLHLERNLLRSLAAGLFRHTPSLASLSLGNNLLGRLEEGLFRGLSHLWDLNLGWNSLVVL 220

  Fly   188 DETLMELFTRQPRSFEYMERLNLAENRLECLHWAIPLAVRRVKVLEMSGNRLSNCSLLNLQYMKQ 252
            .:|:.:       ....:..|.||.|:|..|..|:...:..::.|::|.|.|.:.......::.:
Mouse   221 PDTVFQ-------GLGNLHELVLAGNKLTYLQPALLCGLGELRELDLSRNALRSVKANVFIHLPR 278

  Fly   253 LQELHLDRSELTYL-PQRFLGELSELRMLNLSQNLLTELPRDIFVGALK---------------- 300
            ||:|:|||:.:|.: |:.||| :..||.|:||.|.:..|..|.|.|.|.
Mouse   279 LQKLYLDRNLITAVAPRAFLG-MKALRWLDLSHNRVAGLLEDTFPGLLGLHVLRLAHNAITSLRP 342

  Fly   301 --------LERLYLSGNRLSVLPFMLFQTAADLQVLDLSDNR----------------------- 334
                    ||.|.|..||:..|....|:....|:||.|:||:
Mouse   343 RTFKDLHFLEELQLGHNRIRQLGEKTFEGLGQLEVLTLNDNQIHEVKVGAFFGLFNVAVMNLSGN 407

  Fly   335 -LLSFPDNFFARNGQLRQLHLQRNQLKSIGKHSLYSLRELRQLDLSQNSLSVIDRKAFESLDHLL 398
             |.|.|::.|...|:|..|||:.:.|..|..|:...|..||:|.|..||:|.|:.::...|..||
Mouse   408 CLRSLPEHVFQGLGRLHSLHLEHSCLGRIRLHTFAGLSGLRRLFLRDNSISSIEEQSLAGLSELL 472

  Fly   399 ALNVSGNNLTLLSSIIFQSLHALRQLDLSRNQFKQLPS---GLFQRQRSLVLL--RIDETPIE-Q 457
            .|:::.|.||.|...:||.|..|..|.||.||...|..   |..||...|.|.  |: |||.| .
Mouse   473 ELDLTANQLTHLPRQLFQGLGQLEYLLLSNNQLTMLSEDVLGPLQRAFWLDLSHNRL-ETPAEGL 536

  Fly   458 FSNWISRYDESLVDPQVLHRLRYLSVQQNRKLTYLPATLFANTPNIRELLLAEN 511
            ||:              |.|||||:::.|...|::|      .|.:..|.|..|
Mouse   537 FSS--------------LGRLRYLNLRNNSLQTFVP------QPGLERLWLDAN 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380	7/21 (33%)
		leucine-rich repeat	229..252	CDD:275380	4/22 (18%)
		LRR_RI	<246..433	CDD:238064	74/235 (31%)
		LRR_8	251..311	CDD:290566	27/84 (32%)
		leucine-rich repeat	253..276	CDD:275380	11/23 (48%)
		leucine-rich repeat	277..300	CDD:275380	10/22 (45%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		LRR_8	325..383	CDD:290566	24/81 (30%)
		leucine-rich repeat	325..348	CDD:275380	10/46 (22%)
		leucine-rich repeat	349..372	CDD:275380	8/22 (36%)
		LRR_RI	351..>557	CDD:238064	58/167 (35%)
		LRR_8	371..431	CDD:290566	24/59 (41%)
		leucine-rich repeat	373..396	CDD:275380	9/22 (41%)
		leucine-rich repeat	397..420	CDD:275380	10/22 (45%)
		leucine-rich repeat	421..444	CDD:275380	10/25 (40%)
		LRR_8	477..536	CDD:290566	12/35 (34%)
		leucine-rich repeat	478..502	CDD:275380	7/23 (30%)
		leucine-rich repeat	503..526	CDD:275380	3/9 (33%)
		Ig	<714..761	CDD:299845
Igfals	NP_001351825.1	LRRNT	75..113	CDD:214470	4/11 (36%)
		leucine-rich repeat	92..110	CDD:275380	3/8 (38%)
		PLN00113	96..>558	CDD:331614	138/489 (28%)
		leucine-rich repeat	114..134	CDD:275380	7/28 (25%)
		leucine-rich repeat	135..158	CDD:275380	8/23 (35%)
		leucine-rich repeat	159..182	CDD:275380	4/22 (18%)
		leucine-rich repeat	183..206	CDD:275380	5/22 (23%)
		leucine-rich repeat	207..230	CDD:275380	3/29 (10%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		leucine-rich repeat	255..278	CDD:275380	4/22 (18%)
		leucine-rich repeat	279..302	CDD:275380	11/23 (48%)
		leucine-rich repeat	303..326	CDD:275380	10/22 (45%)
		leucine-rich repeat	327..350	CDD:275380	0/22 (0%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..396	CDD:275380	6/20 (30%)
		leucine-rich repeat	423..446	CDD:275380	8/22 (36%)
		leucine-rich repeat	447..470	CDD:275380	9/22 (41%)
		leucine-rich repeat	471..494	CDD:275380	10/22 (45%)
		leucine-rich repeat	495..516	CDD:275380	8/20 (40%)
		leucine-rich repeat	519..542	CDD:275380	10/37 (27%)
		leucine-rich repeat	543..561	CDD:275380	7/23 (30%)
		TPKR_C2	570..613	CDD:326558	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870