DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16974 and lingo3

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	XP_004911049.2	Gene:	lingo3 / 100497438	XenbaseID:	XB-GENE-6051175	Length:	605	Species:	Xenopus tropicalis

Alignment Length:	608	Identity:	141/608 - (23%)
Similarity:	230/608 - (37%)	Gaps:	153/608 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 RSELTYLPQRFLGELSELRMLNLSQNLLTEL-PRDIFVGALKLERLYLSGNRLSVLPFMLFQTAA 323
            |..||.:|:   |..||.|:|:||:|.:..| |.|....:| ||.:.||.|.:|.:....|....
Frog    47 RKRLTTIPE---GIPSETRLLDLSKNRIRCLNPGDFSPYSL-LEEVDLSENIISTIEPGAFANLF 107

  Fly   324 DLQVLDLSDNRLLSFPDNFFARNGQLRQLHLQRNQLKSIGKHSLYSLRELRQLDLSQNSLSVIDR 388
            .||:|.|..|:|...|...|.:...|..|.:..|::..:.......||.|:.|::..|.|..|.:
Frog   108 FLQILKLKGNQLKLIPTGVFTKLSNLTLLDISENKIVILLDFMFQDLRSLKSLEVGDNDLLYISQ 172

  Fly   389 KAFESLDHLLALNVSGNNLTLLSSIIFQSLHALRQLDLSRNQF---KQLPSGLFQRQRSLVLLRI 450
            |||..|..|..|.:...|||.:|.   :||..|:.|::.|.::   ..|....||:..:|..|.:
Frog   173 KAFYGLVSLDQLTIEKCNLTSISP---ESLSYLQGLEVLRLRYLGINSLEEQNFQKLYNLKELEL 234

  Fly   451 DETP-IEQFSNW-----------ISRYDESLVDPQVLHRLRYLSVQQNRKLTYLPATL-----FA 498
            :..| :|...|.           |:..:.:.|....|..:.||   :...|::.|..:     |.
Frog   235 ESWPLLEDVCNTAFQGLNLTSLSITYTNLTSVPSAALRNMVYL---EYLNLSFNPIRIIQRGAFK 296

  Fly   499 NTPNIRELLLAENGLLQLPTQ-ISGLSRLQRLSVRGNSLGSLPEN-IKELRQLHYLNILGNEYQC 561
            :...:|||.:....|..:.:| ..||.:::.|:|..|.|.:|.|: .:.:..|..|.:..|...|
Frog   297 DLVRLRELHIVGAFLSTVESQAFLGLRQIRLLNVSNNLLATLEESAFQSVNTLETLRVDDNPLAC 361

  Fly   562 DCSMYWLTAWLANTSTSLRHQMPQAQNHSNGSTNQTPLDSYESIDHQIDALKCQYGYRGDMLR-- 624
            ||.:.|:.               |.:...|...:|....|...|             :|:.||
Frog   362 DCRLLWIL---------------QRRKTLNFDNHQPVCASPAKI-------------QGNALRDF 398

  Fly   625 ----VLSKLNCSVPTVVQFSEPKMHKLLS----TAKLECQISGSPVPDIIWVTPRNKILRHHADP 681
                :.....|..|.:   .:.|:..:.:    .....|:..|.|||.|:||:|:.:::...:
Frog   399 PDSILFEHFTCQKPKI---RDRKLQHITAHEGQPVSFHCRADGEPVPLIVWVSPQRRMITSRS-- 458

  Fly   682 DKRPIIIDSKEDAHQPPSAQELAALMDESYIQSLNWTRQNSLVGRRVVLVENGSLLVHNISRIDS 746
                                                      |||..||.| |:|.:......||
Frog   459 ------------------------------------------VGRSTVLPE-GTLEIRYAQVQDS 480

  Fly   747 GLYTCYAFNVMGKAS--------------AGLRLYI---------DPIVF--YRVKIGSILFGTA 786
            |.|.|.|.|..|..:              :...:|:         |..||  :.:.:.:||..||
Frog   481 GTYICIATNAGGNDTYFATLTVKSDNSPYSNRTMYLSEYNDTFHNDTQVFLKFTLDLKTILVSTA 545

  Fly   787 LAT---------AFLLLTLIVQG 800
            :..         .||||.:..:|
Frog   546 MGCITFLGVVLFCFLLLFVWSRG 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_RI	<246..433	CDD:238064	56/176 (32%)
		LRR_8	251..311	CDD:290566	21/51 (41%)
		leucine-rich repeat	253..276	CDD:275380	5/15 (33%)
		leucine-rich repeat	277..300	CDD:275380	8/23 (35%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		LRR_8	325..383	CDD:290566	16/57 (28%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		leucine-rich repeat	349..372	CDD:275380	4/22 (18%)
		LRR_RI	351..>557	CDD:238064	55/227 (24%)
		LRR_8	371..431	CDD:290566	21/59 (36%)
		leucine-rich repeat	373..396	CDD:275380	9/22 (41%)
		leucine-rich repeat	397..420	CDD:275380	8/22 (36%)
		leucine-rich repeat	421..444	CDD:275380	6/25 (24%)
		LRR_8	477..536	CDD:290566	15/64 (23%)
		leucine-rich repeat	478..502	CDD:275380	5/28 (18%)
		leucine-rich repeat	503..526	CDD:275380	7/23 (30%)
		Ig	<714..761	CDD:299845	16/46 (35%)
lingo3	XP_004911049.2	LRR	41..359	CDD:227223	88/321 (27%)
		leucine-rich repeat	61..84	CDD:275380	8/22 (36%)
		leucine-rich repeat	85..108	CDD:275380	7/22 (32%)
		leucine-rich repeat	109..132	CDD:275380	8/22 (36%)
		leucine-rich repeat	133..156	CDD:275380	4/22 (18%)
		leucine-rich repeat	157..180	CDD:275380	9/22 (41%)
		leucine-rich repeat	181..204	CDD:275380	9/25 (36%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		leucine-rich repeat	253..276	CDD:275380	3/22 (14%)
		leucine-rich repeat	277..298	CDD:275380	4/23 (17%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..345	CDD:275380	6/19 (32%)
		PCC	329..>399	CDD:188093	20/97 (21%)
		Ig	413..502	CDD:416386	26/136 (19%)
		Ig strand A'	419..423	CDD:409353	0/3 (0%)
		Ig strand B	429..438	CDD:409353	1/8 (13%)
		Ig strand C	443..448	CDD:409353	2/4 (50%)
		Ig strand C'	451..453	CDD:409353	0/1 (0%)
		Ig strand D	462..465	CDD:409353	0/2 (0%)
		Ig strand E	468..475	CDD:409353	2/6 (33%)
		Ig strand F	481..489	CDD:409353	4/7 (57%)
		Ig strand G	492..502	CDD:409353	1/9 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D195414at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920