Protein Alignment CG16974 and lingo2

DIOPT Version :10

• Sequence 1: NP_609610.2
• Gene: CG16974 / 34713
• FlyBaseID: FBgn0032479
• Length: 1257
• Species: Drosophila melanogaster
• Sequence 2: XP_004910881.1
• Gene: lingo2 / 100490134
• XenbaseID: XB-GENE-922286
• Length: 612
• Species: Xenopus tropicalis
• Alignment Length: 631
• Identity: 150/631 - (23%)
• Similarity: 237/631 - (37%)
• Gaps: 146/631 - (23%)

  Fly   214 RLECLHWAIPLAVRRVKVLEMSGNRLSNCSLLNLQYMKQLQELHLDRSELTYLPQRFLGELSELR 278
            ||..:...||:   ..|:|::|.|:|.:.:.::......|:::.|..:.::.:.......|..||
 Frog    51 RLVTIPEGIPI---ETKILDLSKNKLKSVNPVDFVSYPLLEDIDLSDNIISNVEPGAFNSLFNLR 112

  Fly   279 MLNLSQNLLTELPRDIFVGALKLERLYLSGNRLSVLPFMLFQTAADLQVLDLSDNRLLSFPDNFF 343
            .|:|..|.|..:|..:|.|...|.:|.:|.|::.:|...:||....|:.|::.||.|:......|
 Frog   113 SLSLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHSLKSLEVGDNELVYISHRAF 177

  Fly   344 ARNGQLRQLHLQRNQLKSIGKHSLYSLRELRQLDLSQNSLSVIDRKAFESLDHLLALNVSGNNLT 408
            :....|.||.|::..|.::...:|..|..|..|.|...:::|:...||:.|.||..|.:|  ...
 Frog   178 SGLVSLEQLTLEKCNLTAVPTDALSHLHNLYSLHLKYLNINVLPPFAFKRLFHLKILEIS--YWP 240

  Fly   409 LLSSIIFQSLHALRQLDLSRNQFKQLPSGLFQRQRSLVLLRIDETPIEQFSNWISRYDESLVDPQ 473
            ||..:...||:.|                      :|..|.|..|.:....
 Frog   241 LLDLVPANSLYGL----------------------NLTFLSITNTNLSTIP-------------- 269

  Fly   474 VLHRLRYLSVQQNRKLTYLP-----ATLFANTPNIRELLLAENGLLQL-PTQISGLSRLQRLSVR 532
             .|.|::|....:..|:|.|     ..:|::...::||.|....|..: |....||..|:.|:|.
 Frog   270 -YHALKHLIYLTHLNLSYNPIGIIDTGVFSDLVRLQELHLVGAQLRTIEPHAFQGLRFLRLLNVS 333

  Fly   533 GNSLGSLPEN-IKELRQLHYLNILGNEYQCDCSMYWLTAWLANTSTSLRHQMPQAQNHSNGSTNQ 596
            .|.|.:|.|| .:..:.|..|.|..|...|||.:.|:..         ||.|    .|..|   |
 Frog   334 QNLLETLEENAFQSPKALEVLCIDDNPLVCDCRLIWMLQ---------RHPM----LHFGG---Q 382

  Fly   597 TPLDSYESIDHQIDALKCQYGYRGDMLRVLS-KLNCSVPTV-------VQFSEPKMHKLLSTAKL 653
            .|:.|      ..|:|| :..|:.....||| ...|..|.:       |...|.:      ..::
 Frog   383 QPMCS------SPDSLK-ESSYKVLDAAVLSFYFTCKKPKIRDREMLQVHVDEGQ------RVQM 434

  Fly   654 ECQISGSPVPDIIWVTPRNKILRHHADPDKRPIIIDSKEDAHQPPSAQELAALMDESYIQSLNWT 718
            .|...|.|.|.|.|||||           :|.:.:.|.
 Frog   435 NCNADGDPQPMISWVTPR-----------RRTVSLKSN--------------------------- 461

  Fly   719 RQNSLVGRRVVLVENGSLLVHNISRIDSGLYTCYAFNVMGK--ASAGL--------RLYIDPIVF 773
                  ||..|| .||:|.:......|:|.|.|.|.|..|.  .||.|        |.|.:....
 Frog   462 ------GRTTVL-GNGTLEIRYAQIQDTGTYICVASNAAGNDTFSASLTVKGFVPDRSYTNMTPM 519

  Fly   774 YRVKIG-SILFGTALATAFL--LLTLIVQGLRSCLSRWGICNRFYC 816
            :..::. :...||.....|.  |.|::|.....|.:..|:.  .:|
 Frog   520 FITELNETSTNGTNANMTFNLDLKTILVSTAMGCFTFLGVV--LFC 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_609610.2	leucine-rich repeat	206..228	CDD:275380	4/13 (31%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		LRR	<230..531	CDD:443914	73/306 (24%)
		leucine-rich repeat	253..276	CDD:275380	3/22 (14%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		leucine-rich repeat	349..372	CDD:275380	7/22 (32%)
		leucine-rich repeat	373..396	CDD:275380	7/22 (32%)
		leucine-rich repeat	397..420	CDD:275380	7/22 (32%)
		leucine-rich repeat	421..444	CDD:275380	1/22 (5%)
		leucine-rich repeat	478..502	CDD:275380	6/28 (21%)
		leucine-rich repeat	503..526	CDD:275380	7/23 (30%)
		Ig	<714..761	CDD:472250	14/48 (29%)
		Ig strand C	714..718	CDD:409358	0/3 (0%)
		Ig strand E	734..738	CDD:409358	2/3 (67%)
		Ig strand F	748..753	CDD:409358	2/4 (50%)
lingo2	XP_004910881.1	LRRNT	31..64	CDD:214470	4/15 (27%)
		leucine-rich repeat	43..61	CDD:275380	3/9 (33%)
		LRR	52..>343	CDD:443914	80/332 (24%)
		leucine-rich repeat	63..86	CDD:275380	5/22 (23%)
		leucine-rich repeat	87..110	CDD:275380	3/22 (14%)
		leucine-rich repeat	111..134	CDD:275380	9/22 (41%)
		leucine-rich repeat	135..158	CDD:275380	7/22 (32%)
		leucine-rich repeat	159..182	CDD:275380	6/22 (27%)
		leucine-rich repeat	183..206	CDD:275380	7/22 (32%)
		leucine-rich repeat	207..254	CDD:275380	16/70 (23%)
		leucine-rich repeat	255..278	CDD:275380	7/37 (19%)
		leucine-rich repeat	279..302	CDD:275380	4/22 (18%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..347	CDD:275380	8/19 (42%)
		LRRCT	359..402	CDD:214507	17/65 (26%)
		Ig	415..504	CDD:472250	31/139 (22%)
		Ig strand B	432..436	CDD:409353	0/3 (0%)
		Ig strand C	445..449	CDD:409353	1/3 (33%)
		Ig strand E	470..474	CDD:409353	2/3 (67%)
		Ig strand F	484..489	CDD:409353	2/4 (50%)
		Ig strand G	497..500	CDD:409353	0/2 (0%)