DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16974 and LOC100151059

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	XP_017207970.1	Gene:	LOC100151059 / 100151059	-ID:	-	Length:	605	Species:	Danio rerio

Alignment Length:	638	Identity:	138/638 - (21%)
Similarity:	225/638 - (35%)	Gaps:	142/638 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 MERLNLAENRLECLHWAIPLAVRRVKVLEMSGNRLSNCSLLNLQYMKQLQELHLDRSELTYLPQR 269
            :..::....||..:...:|...|   :|::|.|||...:..:|....:|:||.|..:.::.|...
Zfish    37 LRSVSCQRRRLSAVPEGVPTETR---LLDLSRNRLRWVAAGDLAPYPRLEELDLSENLISTLEPN 98

  Fly   270 FLGELSELRMLNLSQNLLTELPRDIFVGALKLERLYLSGNRLSVLPFMLFQTAADLQVLDLSDNR 334
            ....|..||.|.|..|.|..:|...|.....|..|.||.||:.:|....||....|:.|::.||.
Zfish    99 AFANLQALRTLRLRANQLKLVPMGAFARLTNLTTLDLSENRIVILLDFTFQDLRSLKNLEVGDND 163

  Fly   335 LLSFPDNFFARNGQLRQLHLQRNQLKSIGKHSLYSLRELRQLDLSQNSLSVIDRKAFESLDHLLA 399
            |:......|:....|..|.:.|..|.||...:|..||.|..|.|...|:|.::.:.|..|..|..
Zfish   164 LVYISHKAFSGLLSLEDLTMARCNLTSISGQTLSYLRGLVTLRLRHLSISTLEEQNFRKLTALRG 228

  Fly   400 LNV-SGNNLTLLSSIIFQSLHALRQLDLSRNQFKQLPSGLFQRQRSLVLLRIDETPIEQFSNWIS 463
            |.: ....|..:|.:.||.|: |..|.::......:||..|:....|..|.:...||....:|
Zfish   229 LEIHDWPFLEFISPLSFQGLN-LSWLFITNTNITSVPSASFRNLAYLTALNLSYNPISTLESW-- 290

  Fly   464 RYDESLVDPQVLHRLRYLSVQQNRKLTYLPATLFANTPNIRELLLAENGLLQL-PTQISGLSRLQ 527
                                            .|.:...::||.:....||.: |..:.||.:::
Zfish   291 --------------------------------AFRDLIRLKELHMVSTNLLTVEPHALGGLRQIR 323

  Fly   528 RLSVRGNSLGSLPE-NIKELRQLHYLNILGNEYQCDCSMYWLTAWLANTSTSLRHQM------PQ 585
            .|::..|.|.:|.| :...:..|..|.:.||...|||.:.|:..  ...:.:...:|      |:
Zfish   324 VLNLSNNDLVTLEESSFHSVNSLETLRVDGNPLSCDCRLLWILQ--RRRTLNFDGKMPVCAGPPE 386

  Fly   586 AQNHSNGSTNQTPLDSYESIDHQIDALKCQYGYRGDMLRVLSKLNCSVPTVVQFSEPKMHKLL-- 648
            .|.:.......:.|..|                          ..|..|.:   ...||.:::
Zfish   387 VQGYLLSMFTDSALFDY--------------------------FTCQKPKI---RNRKMQQVMVH 422

  Fly   649 --STAKLECQISGSPVPDIIWVTPRNKILRHHADPDKRPIIIDSKEDAHQPPSAQELAALMDESY 711
              ......|:..|.|.|.|||::|:.:             .|.||.:.
Zfish   423 EGQPVSFLCRAEGEPTPAIIWISPQRR-------------RITSKSNG----------------- 457

  Fly   712 IQSLNWTRQNSLVGRRVVLVENGSLLVHNISRIDSGLYTCYAFNVMGKASAGLRLY-----IDPI 771
                           ||.::..|:|.:......|||.|.|.|.|..|..:....|.     :|..
Zfish   458 ---------------RVTVLPGGTLEIRYAQLTDSGTYICIASNAGGNDTYFATLTVKGQPVDAA 507

  Fly   772 VFYRVKIGSILF---GTALATAFL-----LLTLIVQGLRSCLSRWGICNRFYC 816
            :|....:.::.|   |......||     |.|::|.....|:...|:.  .:|
Zfish   508 IFSNRSMYAMDFNETGLNSTRVFLKFTLDLTTILVSTAMGCIMFLGVV--LFC 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380	3/21 (14%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRR_RI	<246..433	CDD:238064	55/187 (29%)
		LRR_8	251..311	CDD:290566	19/59 (32%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		LRR_8	325..383	CDD:290566	18/57 (32%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		leucine-rich repeat	349..372	CDD:275380	8/22 (36%)
		LRR_RI	351..>557	CDD:238064	47/208 (23%)
		LRR_8	371..431	CDD:290566	17/60 (28%)
		leucine-rich repeat	373..396	CDD:275380	7/22 (32%)
		leucine-rich repeat	397..420	CDD:275380	7/23 (30%)
		leucine-rich repeat	421..444	CDD:275380	5/22 (23%)
		LRR_8	477..536	CDD:290566	10/59 (17%)
		leucine-rich repeat	478..502	CDD:275380	1/23 (4%)
		leucine-rich repeat	503..526	CDD:275380	7/23 (30%)
		Ig	<714..761	CDD:299845	12/46 (26%)
LOC100151059	XP_017207970.1	LRRNT	26..60	CDD:214470	4/25 (16%)
		leucine-rich repeat	37..56	CDD:275380	2/18 (11%)
		leucine-rich repeat	58..81	CDD:275380	7/25 (28%)
		LRR_RI	61..332	CDD:238064	78/305 (26%)
		LRR_8	80..140	CDD:290566	19/59 (32%)
		leucine-rich repeat	82..105	CDD:275380	6/22 (27%)
		leucine-rich repeat	106..129	CDD:275380	8/22 (36%)
		LRR_8	128..188	CDD:290566	18/59 (31%)
		leucine-rich repeat	130..153	CDD:275380	9/22 (41%)
		leucine-rich repeat	154..177	CDD:275380	6/22 (27%)
		leucine-rich repeat	178..201	CDD:275380	8/22 (36%)
		leucine-rich repeat	202..225	CDD:275380	7/22 (32%)
		leucine-rich repeat	226..249	CDD:275380	6/22 (27%)
		LRR_8	249..308	CDD:290566	13/93 (14%)
		leucine-rich repeat	250..273	CDD:275380	5/22 (23%)
		leucine-rich repeat	274..295	CDD:275380	6/54 (11%)
		LRR_8	297..356	CDD:290566	16/58 (28%)
		leucine-rich repeat	298..321	CDD:275380	7/22 (32%)
		leucine-rich repeat	322..342	CDD:275380	5/19 (26%)
		leucine-rich repeat	346..358	CDD:275378	4/11 (36%)
		TPKR_C2	354..394	CDD:301599	8/41 (20%)
		I-set	409..499	CDD:254352	27/137 (20%)
		Ig	424..492	CDD:299845	23/112 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D195414at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920