DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16974 and islr2

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001120371.1	Gene:	islr2 / 100145445	XenbaseID:	XB-GENE-5920691	Length:	691	Species:	Xenopus tropicalis

Alignment Length:	550	Identity:	100/550 - (18%)
Similarity:	165/550 - (30%)	Gaps:	235/550 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 CSLLNLQYMKQLQELHLDRSELTY-----LPQRFLGELSELRMLNLSQNLLTELPRDIFVGALKL 301
            ||.:: :|.:|.       ::.||     :|..|   .|.:..|:||.|.:|.|.:..|:|..::
Frog    24 CSCVD-KYNQQF-------ADCTYKKLQKIPSGF---PSNVTTLSLSANKITSLKKSDFIGVPQV 77

  Fly   302 ERLYLSGNRLSVLPFMLFQTAADLQVLDLSDNRLLSFPDNFFARNGQLRQLHLQRNQLKSIGKHS 366
            ..|:|:.|.:|.:......|..:|:.||:|.|.|:.||                        ...
Frog    78 TSLWLAHNEISEIEEGALATMVNLKNLDVSHNLLVEFP------------------------WRD 118

  Fly   367 LYSLRELRQLDLSQNSLSVIDRKAFESLDHLLALNVSGNNLTLLSSIIFQSLHALRQLDLSRNQF 431
            |.||..|:.:.::.|.:..:.|.|                        ||:|:.|:.|.::.|||
Frog   119 LASLSALQLIKMNNNRMVNLPRDA------------------------FQNLNELKSLRINNNQF 159

  Fly   432 KQLPSGLFQRQRSLVLLRIDETPIEQFSNWISRYDESLVDPQVLHRLRYLSVQQNRKLTYLPATL 496
            ..:..|.|
Frog   160 SVIQEGTF--------------------------------------------------------- 167

  Fly   497 FANTPNIRELLLAENGLLQLPTQISGLSRLQRLSVRGNSLGSLPENIKELRQLHYLNILGNEYQC 561
                                                           |.|..|.::.|..|.:.|
Frog   168 -----------------------------------------------KPLISLSHIQIYNNPFHC 185

  Fly   562 DCSMYWLTAWLANTSTSLRHQMPQAQNHSNGSTNQTPLDSYESIDHQIDALKCQYGYRGDMLRVL 626
            .||:.||..|......|    :|:..|.:..|..:                     .:|..:..:
Frog   186 SCSLMWLKKWAEEAQFS----VPEKDNIACSSPEE---------------------LKGTPISKI 225

  Fly   627 SKLNCSVPTVVQFSEPKMH--KLLS--TAKLECQISGSPVPDIIW----VTPRNKILRHHADPDK 683
            ..|.|..|||.....|.:.  :|..  |..|:|..||.|.|.|.|    .|...:|        |
Frog   226 PDLPCEAPTVQLSYYPNLDSTELYDGFTLSLQCLASGIPQPTIKWKVRNATQETEI--------K 282

  Fly   684 RPIIIDSKEDAHQPPSAQELAALMDESYIQSLNWTRQNSLVGRRVVLVENGSLLVHNISRIDSGL 748
            :|:....|..|....|:..|                          :.:||:|::.::|:...|.
Frog   283 QPVDGQVKGSAKSQKSSSFL--------------------------VFQNGTLVIPHLSKKMEGT 321

  Fly   749 YTCYAFNVMGKASAGLRLYIDPIVFYRVKI 778
            |.|...|.||.:.|.:.:.:.....|..|:
Frog   322 YICEGNNEMGSSQASVNVSVAGSQKYPTKV 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380	3/9 (33%)
		LRR_RI	<246..433	CDD:238064	43/191 (23%)
		LRR_8	251..311	CDD:290566	17/64 (27%)
		leucine-rich repeat	253..276	CDD:275380	4/27 (15%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		LRR_8	325..383	CDD:290566	13/57 (23%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		leucine-rich repeat	349..372	CDD:275380	3/22 (14%)
		LRR_RI	351..>557	CDD:238064	21/205 (10%)
		LRR_8	371..431	CDD:290566	10/59 (17%)
		leucine-rich repeat	373..396	CDD:275380	4/22 (18%)
		leucine-rich repeat	397..420	CDD:275380	3/22 (14%)
		leucine-rich repeat	421..444	CDD:275380	7/22 (32%)
		LRR_8	477..536	CDD:290566	0/58 (0%)
		leucine-rich repeat	478..502	CDD:275380	0/23 (0%)
		leucine-rich repeat	503..526	CDD:275380	0/22 (0%)
		Ig	<714..761	CDD:299845	10/46 (22%)
islr2	NP_001120371.1	leucine-rich repeat	36..52	CDD:275380	4/18 (22%)
		LRR_8	51..111	CDD:290566	19/59 (32%)
		LRR_4	52..92	CDD:289563	12/39 (31%)
		leucine-rich repeat	53..76	CDD:275380	8/22 (36%)
		LRR_4	75..115	CDD:289563	11/39 (28%)
		leucine-rich repeat	77..100	CDD:275380	5/22 (23%)
		LRR_8	100..159	CDD:290566	21/106 (20%)
		leucine-rich repeat	101..124	CDD:275380	11/46 (24%)
		leucine-rich repeat	125..148	CDD:275380	7/46 (15%)
		leucine-rich repeat	149..172	CDD:275380	9/126 (7%)
		LRRCT	181..>219	CDD:214507	11/62 (18%)
		IG_like	251..341	CDD:214653	28/123 (23%)
		Ig	254..338	CDD:143165	27/117 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100