DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16974 and lrrn4

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001120279.1	Gene:	lrrn4 / 100145335	XenbaseID:	XB-GENE-877010	Length:	705	Species:	Xenopus tropicalis

Alignment Length:	745	Identity:	157/745 - (21%)
Similarity:	238/745 - (31%)	Gaps:	307/745 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 TELP-RDIFVGALKLERLYLSGNRLSVLPFMLFQTAADLQVLDLSDNRLLSFPDNFFARNGQLRQ 351
            ||.| :::..|    ..:.||...|||.|..|   .:|.:.||:|:|.|.:......:|..||:.
Frog    28 TEKPCKELHHG----RNISLSSRSLSVFPQCL---PSDTEALDMSNNSLTTITQPSLSRFSQLQW 85

  Fly   352 LHLQRNQLKSIGKHSLYS----LRELRQLDLSQNSLSVIDRKAFESLDHLLALNVSGNNLTLLSS 412
            |.|:.||::.|     |.    |..|..||||.|:||.:.|  ...|..|..|:::.|.::.:..
Frog    86 LDLKDNQIQDI-----YCGSDVLENLEYLDLSSNNLSDVPR--CSKLQRLKWLSLARNPISQIQD 143

  Fly   413 IIFQSLHALRQLDLSRNQFKQLPSG---LFQRQRSLVLLRIDETPIEQ-------FSNWISR--- 464
            ..|....:|..|:||..:..:.|||   :|.     ..|::...|::.       .|.::|.
Frog   144 FAFSYFPSLVFLNLSYTELGKSPSGDLSVFS-----FALKVPGAPVKSSIETLDLSSTFLSEVGP 203

  Fly   465 ------------YDESLVDPQVLH--------RLRYLSVQQNRKLTYLPATLFANTPNIRELLLA 509
                        |..|:.:.:.|.        ||..||...:..|..|..:||
Frog   204 FWTSYLKNLKELYLRSMSNIKTLEKILTLDFPRLELLSCAHSSALASLDQSLF------------ 256

  Fly   510 ENGLLQLPTQISGLSRLQRLSVRGNSLGSLPE-NIKELRQLHY-LNILGNEYQCDCSMYWLTAWL 572
            |||           |.|:.:.:...:|.::|: ||.   ..|. |.:|||...|.|.|.||.:..
Frog   257 ENG-----------SHLKHVDLENCNLTAVPQWNIS---SPHLSLVLLGNPLACRCDMTWLVSEQ 307

  Fly   573 ANTSTSLR---------------------------------HQMPQAQNHSNGS----------- 593
            .|. |.:|                                 :..|.|.|..|.|
Frog   308 INV-TLIRANETLCRQGDGLEISLVQLNGECQKKPTPYATVNNTPTAANSLNDSVVFTSTPLHLT 371

  Fly   594 ----TNQTPLD---------------------SYESID--HQIDALKC-------------QYG- 617
                |:..|||                     |.:|.:  ||..|.:.             .:|
Frog   372 PPHETSTVPLDKATITQKVEKNTGIITVFKQTSSDSFNGQHQNPATQATTVLLEGTNVPTTSFGK 436

  Fly   618 -------YRGDML-------------------------RVLSKLNCSVPTVVQFSEPKMH----- 645
                   :.|..|                         .|..|.|.|||..:    |:||
Frog   437 SEAATKYFSGTSLSKDSGLTLRTSTINSLVGQITQPPPTVSKKPNISVPLEL----PEMHTGDYY 497

  Fly   646 --------KLLSTAK-----------LECQ------------ISGSPVPDIIWVTPRNKILRHHA 679
                    .|.||:|           .||.            ::|:.||
Frog   498 YDDTQQTTTLKSTSKPCDYKPCRHLQTECHELQRLTPCFCPGLTGNNVP---------------- 546

  Fly   680 DPDKRPIIIDSKEDAHQPPSAQELAALMDESYIQSLNWTRQNSLVGRRVVLV----ENGSLLVHN 740
             ||              ||..|..:.:.|.|  ..::|...||.||:..::.    :....:|.|
Frog   547 -PD--------------PPMMQGASEITDTS--AQIHWCAPNSRVGKYQLIYRPEGDKNQTVVDN 594

  Fly   741 ISRIDSGLYTCY-------------AFNVMGKASAGLRLYID---PIVFYRVKIGSILFGTALAT 789
            | .|.|..||.|             :||..|.:..   |..|   |...:|.|...:....||.|
Frog   595 I-YITSRKYTLYNLLPDTTYHICALSFNTAGSSQP---LNDDSRFPCTEFRTKPSYVGILAALCT 655

  Fly   790 A-----FLLLTLIVQGLRSCLSRWGICNRF 814
            .     ..::.|.|...::|  |..:.|::
Frog   656 VAGVAMVAIIVLSVYLYKAC--RNNLINQY 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_RI	<246..433	CDD:238064	45/149 (30%)
		LRR_8	251..311	CDD:290566	6/23 (26%)
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380	4/12 (33%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		LRR_8	325..383	CDD:290566	21/61 (34%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		leucine-rich repeat	349..372	CDD:275380	8/26 (31%)
		LRR_RI	351..>557	CDD:238064	56/244 (23%)
		LRR_8	371..431	CDD:290566	18/59 (31%)
		leucine-rich repeat	373..396	CDD:275380	10/22 (45%)
		leucine-rich repeat	397..420	CDD:275380	4/22 (18%)
		leucine-rich repeat	421..444	CDD:275380	8/25 (32%)
		LRR_8	477..536	CDD:290566	13/58 (22%)
		leucine-rich repeat	478..502	CDD:275380	7/23 (30%)
		leucine-rich repeat	503..526	CDD:275380	4/22 (18%)
		Ig	<714..761	CDD:299845	16/63 (25%)
lrrn4	NP_001120279.1	LRR_RI	<33..164	CDD:238064	42/144 (29%)
		leucine-rich repeat	39..58	CDD:275380	7/21 (33%)
		leucine-rich repeat	59..82	CDD:275380	6/22 (27%)
		LRR_8	62..116	CDD:290566	21/58 (36%)
		leucine-rich repeat	83..105	CDD:275380	8/26 (31%)
		LRR_8	105..162	CDD:290566	18/58 (31%)
		leucine-rich repeat	106..127	CDD:275380	10/22 (45%)
		leucine-rich repeat	128..151	CDD:275380	4/22 (18%)
		AMN1	138..>297	CDD:187754	38/189 (20%)
		leucine-rich repeat	152..187	CDD:275380	10/39 (26%)
		leucine-rich repeat	188..211	CDD:275380	2/22 (9%)
		leucine-rich repeat	212..239	CDD:275380	5/26 (19%)
		leucine-rich repeat	240..261	CDD:275380	9/43 (21%)
		FN3	547..642	CDD:238020	26/114 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910