DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16974 and lingo4a

DIOPT Version :9

Sequence 1:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster
Sequence 2:	NP_001076447.1	Gene:	lingo4a / 100005227	ZFINID:	ZDB-GENE-060503-275	Length:	618	Species:	Danio rerio

Alignment Length:	647	Identity:	154/647 - (23%)
Similarity:	242/647 - (37%)	Gaps:	158/647 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 LHWAI------PLAVR-----RVKVLEMSGNRLS--------NCSLLNLQYMKQLQELHLDRSEL 263
            |.|.:      |.|.|     ::.:::.|..:||        ...:|||.|           :.|
Zfish    30 LQWVVGVATSGPCAQRCDCSPKLPLVDCSSQQLSAVPEGVPDATQVLNLTY-----------NHL 83

  Fly   264 TYLPQRFLGELSELRMLNLSQNLLTELPRDIFVGALKLERLYLSGNRLSVLPFMLFQTAADLQVL 328
            ..|..|....|.:||.|:||.|:||.:..:.|||...|..|.||.|||.::|...|....::|.|
Zfish    84 KTLSSRQFFSLRQLRELDLSANMLTVIEVEAFVGLQNLITLRLSRNRLKIIPVGAFSGLPNVQFL 148

  Fly   329 DLSDNRLLSFPDNFFARNGQLRQLHLQRNQLKSIGKHSLYSLRELRQLDLSQNSLSVIDRKAFES 393
            |:|:|.:|...|:.|.                        .:..|::|:.|:|.|..|..:||..
Zfish   149 DISENEILVLLDDMFG------------------------EMPSLQKLEASENDLVFISNRAFSG 189

  Fly   394 LDHLLALNVSGNNLTLLSSIIFQSLHALRQLDLSRNQFKQLPSGLFQRQRSLVLLRIDETP---- 454
            |.:||.|.:...|||.:.|..|..|..|:.|...|.....||:..|::.:.|..|.:...|
Zfish   190 LPNLLELRLERCNLTTVPSEAFSRLTGLQHLRFCRLGLTALPNNSFRQLQRLQDLHVSRCPWLHT 254

  Fly   455 --------IEQFSNWISRYDESLVDPQVLHR---LRYLSVQQNRKLTYLPATLFANTPNIRELLL 508
                    :...|..:|..:.|.|....||.   ||||.:..| .:|.:.:.|..:...::||.|
Zfish   255 LAVNSLIGLNLTSLTLSHCNLSAVPYAPLHHLVYLRYLDLSYN-PITTVLSGLLGDLLRLQELHL 318

  Fly   509 AENGLLQLPT-QISGLSRLQRLSVRGNSLGSLPEN-IKELRQLHYLNILGNEYQCDCSMYWLTAW 571
            ...|||.:.: ....|:..:.|:|..|.|.:|.|: ...:..|..|.:.||...|||.:.|:
Zfish   319 VSTGLLHVESGAFRNLAFFRLLNVSDNRLVTLEESAFHAVGSLEVLRLDGNPLACDCRLLWV--- 380

  Fly   572 LANTSTSLRHQMP-QAQNHSNGSTNQTPLDSYESIDHQIDALKCQYGYRGDMLRVLSKLNCSVPT 635
                   :|.::. :...|:....:...:......|.....:...:..|  ..|:|::    .|.
Zfish   381 -------MRRRLRLRFAGHAPSCVSPVQVQGRMFQDFAESEVARTFTCR--QARILTR----KPQ 432

  Fly   636 VVQFSEPKMHKLLSTAKLECQISGSPVPDIIWVTPRNKILRHHADPDKRPIIIDSKEDAHQPPSA 700
            .|:..|.  |.:|    ..|...|.|.|.|||:.|:..:|
Zfish   433 DVRSDEG--HTVL----FFCAADGDPAPSIIWLNPKRSVL------------------------- 466

  Fly   701 QELAALMDESYIQSLNWTRQNSLVGRRVVLVENGSLLVHNISRIDSGLYTCYAFNVMGKASAGLR 765
                                  ....|:.::.||:|.|......|||.|.|.|.|..|..|..:.
Zfish   467 ----------------------TASGRIRVLPNGTLEVRYAQVQDSGYYLCIASNAAGNDSISVS 509

  Fly   766 LYIDPI-VFYRVKIGS-ILFGTALATA-----------FLLLTLIV---QGLRSCLSRWGIC 811
            |.:... ...|.:.|| .|.|.:.|:.           |.:.||::   .|..|.||...:|
Zfish   510 LRVRGFPASSRNRSGSFFLDGWSFASGQTAVNGSQPFPFDVKTLVIAVTMGFLSFLSSVALC 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380	5/20 (25%)
		leucine-rich repeat	229..252	CDD:275380	7/30 (23%)
		LRR_RI	<246..433	CDD:238064	56/186 (30%)
		LRR_8	251..311	CDD:290566	20/59 (34%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	11/22 (50%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		LRR_8	325..383	CDD:290566	12/57 (21%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		leucine-rich repeat	349..372	CDD:275380	0/22 (0%)
		LRR_RI	351..>557	CDD:238064	55/222 (25%)
		LRR_8	371..431	CDD:290566	21/59 (36%)
		leucine-rich repeat	373..396	CDD:275380	9/22 (41%)
		leucine-rich repeat	397..420	CDD:275380	9/22 (41%)
		leucine-rich repeat	421..444	CDD:275380	6/22 (27%)
		LRR_8	477..536	CDD:290566	17/62 (27%)
		leucine-rich repeat	478..502	CDD:275380	7/23 (30%)
		leucine-rich repeat	503..526	CDD:275380	7/23 (30%)
		Ig	<714..761	CDD:299845	13/46 (28%)
lingo4a	NP_001076447.1	LRRNT	41..70	CDD:214470	6/28 (21%)
		leucine-rich repeat	52..72	CDD:275380	3/19 (16%)
		leucine-rich repeat	73..96	CDD:275380	8/33 (24%)
		LRR_RI	88..380	CDD:238064	90/316 (28%)
		LRR_8	95..155	CDD:290566	25/59 (42%)
		leucine-rich repeat	97..120	CDD:275380	11/22 (50%)
		leucine-rich repeat	121..144	CDD:275380	9/22 (41%)
		leucine-rich repeat	145..168	CDD:275380	8/46 (17%)
		leucine-rich repeat	169..192	CDD:275380	9/22 (41%)
		LRR_8	191..250	CDD:290566	17/58 (29%)
		leucine-rich repeat	193..216	CDD:275380	9/22 (41%)
		leucine-rich repeat	217..240	CDD:275380	6/22 (27%)
		leucine-rich repeat	241..288	CDD:275380	9/46 (20%)
		LRR_8	264..323	CDD:290566	16/59 (27%)
		leucine-rich repeat	289..310	CDD:275380	7/21 (33%)
		LRR_8	312..371	CDD:290566	17/58 (29%)
		leucine-rich repeat	313..336	CDD:275380	7/22 (32%)
		leucine-rich repeat	337..356	CDD:275380	6/18 (33%)
		I-set	428..512	CDD:254352	29/140 (21%)
		Ig	439..512	CDD:299845	26/125 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D195414at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920