DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rsph1 and Als2

DIOPT Version :9

Sequence 1:NP_609609.1 Gene:Rsph1 / 34712 FlyBaseID:FBgn0032478 Length:344 Species:Drosophila melanogaster
Sequence 2:NP_001153420.2 Gene:Als2 / 74018 MGIID:1921268 Length:1651 Species:Mus musculus


Alignment Length:277 Identity:62/277 - (22%)
Similarity:102/277 - (36%) Gaps:73/277 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 GRNAAGQRQGRGWAILPNGDQYDGNYRKGRRHGIGVY-----VFKDGSRYYGQYRCGKRCGRGIF 89
            ||..:|:..|||....|:|..|.|.:|.|...|.|.|     .......|.|.::.||.||:|::
Mouse  1045 GRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKALNKEDHYVGHWKEGKMCGQGVY 1109

  Fly    90 IYPDGSVYEGNWRKNLKHG-----KGRYKYVNGDNYSGDWFKGQRHGVGIYHFNSGKDGCCLSVR 149
            .|..|.|:||.::.|::||     .|:....:...:.|.|...::.|.|::      |......:
Mouse  1110 SYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVF------DDITRGEK 1168

  Fly   150 MKATWNSNMRTG------PFELY----------IGN-----ED------------------KCTI 175
            ....|..::..|      .|.||          :||     ||                  ..|:
Mouse  1169 YMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTM 1233

  Fly   176 LHGIWDNLYPSGPAVFSFNNRYLLLG-YFLPASYNMK-------------AISNEDEMEDAEERL 226
            .||.:...|.||    .:.:...:.| ||.|:.|...             |::.:::.....|..
Mouse  1234 PHGDYIEGYFSG----EWGSGIKITGTYFKPSLYESDKDKPKAFRKLGNLAVAADEKWRAVFEEC 1294

  Fly   227 EDEMGEAEPMEPTLWFA 243
            ..::|...|.:..:|.|
Mouse  1295 WRQLGCESPGQGEVWKA 1311

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rsph1NP_609609.1 MORN 51..73 CDD:280628 7/26 (27%)
MORN 72..93 CDD:197832 8/20 (40%)
MORN 95..116 CDD:197832 7/25 (28%)
MORN 118..137 CDD:197832 4/18 (22%)
Als2NP_001153420.2 RCC1 1. /evidence=ECO:0000305 59..108
RCC1_2 93..122 CDD:290274
RCC1 2. /evidence=ECO:0000305 109..167
RCC1 109..165 CDD:278826
RCC1 3. /evidence=ECO:0000305 169..218
RCC1 170..216 CDD:278826
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 425..462
RCC1 4. /evidence=ECO:0000305 519..570
RCC1 521..568 CDD:278826
RCC1 5. /evidence=ECO:0000305 572..621
RCC1 573..619 CDD:278826
RhoGEF 689..873 CDD:295373
PH_alsin 899..1004 CDD:241423
PH 920..998 CDD:278594
COG4642 1043..1182 CDD:226989 38/142 (27%)
MORN 1 1043..1065 8/19 (42%)
MORN 1043..1063 CDD:280628 7/17 (41%)
MORN 2 1066..1088 7/21 (33%)
MORN 3 1094..1116 9/21 (43%)
MORN 1094..1114 CDD:280628 8/19 (42%)
MORN 4 1117..1139 6/21 (29%)
MORN 5 1145..1167 5/27 (19%)
COG4642 1166..>1266 CDD:226989 20/103 (19%)
MORN 6 1169..1191 3/21 (14%)
MORN 7 1192..1214 4/21 (19%)
MORN 8 1215..1238 3/22 (14%)
VPS9 1548..1647 CDD:280383
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG4642
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.