DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rsph1 and ALS2

DIOPT Version :9

Sequence 1:NP_609609.1 Gene:Rsph1 / 34712 FlyBaseID:FBgn0032478 Length:344 Species:Drosophila melanogaster
Sequence 2:NP_065970.2 Gene:ALS2 / 57679 HGNCID:443 Length:1657 Species:Homo sapiens


Alignment Length:206 Identity:55/206 - (26%)
Similarity:84/206 - (40%) Gaps:39/206 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 GRNAAGQRQGRGWAILPNGDQYDGNYRKGRRHGIGVY-----VFKDGSRYYGQYRCGKRCGRGIF 89
            ||..:|:..|||....|:|..|.|.:|.|...|.|.|     .......|.|.::.||.||:|::
Human  1051 GRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVY 1115

  Fly    90 IYPDGSVYEGNWRKNLKHG-----KGRYKYVNGDNYSGDWFKGQRHGVGIYHFNSGKDGCCLSVR 149
            .|..|.|:||.::.|::||     .|:....:...:.|.|...::.|.|::      |......:
Human  1116 SYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVF------DDITRGEK 1174

  Fly   150 MKATWNSNMRTG------PFELY----------IGN-----EDKCTILHGIW-DNLYPSGPAVFS 192
            ....|..::..|      .|.||          :||     ||. ||..|.: |:...||....:
Human  1175 YMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDD-TIYEGEFSDDWTLSGKGTLT 1238

  Fly   193 FNNRYLLLGYF 203
            ..|...:.|||
Human  1239 MPNGDYIEGYF 1249

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rsph1NP_609609.1 MORN 51..73 CDD:280628 7/26 (27%)
MORN 72..93 CDD:197832 8/20 (40%)
MORN 95..116 CDD:197832 7/25 (28%)
MORN 118..137 CDD:197832 4/18 (22%)
ALS2NP_065970.2 RCC1 1. /evidence=ECO:0000305 59..108
RCC1_2 93..122 CDD:290274
RCC1 2. /evidence=ECO:0000305 109..167
RCC1 109..165 CDD:278826
RCC1 3. /evidence=ECO:0000305 169..218
RCC1 170..216 CDD:278826
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 432..480
RCC1 4. /evidence=ECO:0000305 525..576
RCC1 527..574 CDD:278826
RCC1 5. /evidence=ECO:0000305 578..627
RCC1 579..625 CDD:278826
RhoGEF 695..879 CDD:295373
PH_alsin 905..1010 CDD:241423
PH 926..1004 CDD:278594
COG4642 1049..1188 CDD:226989 38/142 (27%)
MORN 1 1049..1071 8/19 (42%)
MORN 1049..1069 CDD:280628 7/17 (41%)
MORN 2 1072..1094 7/21 (33%)
MORN 3 1100..1122 9/21 (43%)
MORN 1100..1120 CDD:280628 8/19 (42%)
MORN 4 1123..1145 6/21 (29%)
MORN 5 1151..1173 5/27 (19%)
MORN 6 1175..1197 3/21 (14%)
MORN 7 1198..1220 4/22 (18%)
MORN 8 1221..1244 5/22 (23%)
VPS9 1554..1653 CDD:280383
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG4642
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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