DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rsph1 and Jph2

DIOPT Version :9

Sequence 1:	NP_609609.1	Gene:	Rsph1 / 34712	FlyBaseID:	FBgn0032478	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_001033063.1	Gene:	Jph2 / 296345	RGDID:	1305196	Length:	692	Species:	Rattus norvegicus

Alignment Length:	352	Identity:	79/352 - (22%)
Similarity:	104/352 - (29%)	Gaps:	136/352 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 GLYIGGRNAAGQRQGRGWAILPNGD-QYDGNYRKGRRHGIGVYVFKDGSRYYGQYRCGKRCGRGI 88
            |.|.||.. .|:..|.|....|.|. :|.|::..|.... |||.:..|:.:.|.:..|||.|.||
  Rat    12 GAYCGGWE-GGKAHGHGLCTGPKGQGEYSGSWNFGFEVA-GVYTWPSGNTFEGYWSQGKRHGLGI 74

  Fly    89 -----FIYP------------------DGSVYEGNWRKNLKHGKGRYKYVNGDNYSGDWFKGQRH 130
                 ::|.                  .|:.|||.|...|:.|.|...|.:|..|.|.:..|.||
  Rat    75 ETKGRWLYKGEWTHGFKGRYGIRQSTNSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRH 139

  Fly   131 GVGIYHFNSGKDGCCLSVRMKATWNSNMRTGPFELYIGNEDKCTILHGIWDNLYPSGPAVFSFNN 195
            |.|:.  .|...|..:.||      |.:||....|
  Rat   140 GYGVR--QSVPYGMAVVVR------SPLRTSLSSL------------------------------ 166

  Fly   196 RYLLLGYFLPASYNMKAISNEDEMEDAEERLEDEMGEAEPMEPTLWFAQEMAVYDFSLLPQEPVP 260
                                         |.|...|...|..|..         |...||..|||
  Rat   167 -----------------------------RSEHSNGTVAPDSPAA---------DGPTLPLPPVP 193

  Fly   261 -----------------------------LAISDSELSVCSLSTEPSMRSEEKISWYGE----GE 292
                                         |..|:|..|:.|..:..|....|..|...:    |.
  Rat   194 RGGFALSLLATAEAARPPGLFTRGALLGRLRRSESRTSLGSQRSRLSFLKSELSSGASDAASTGS 258

  Fly   293 EAEGEEGGEMECFPCECDLTDVSEVET 319
            .|||.||.:....|.:.|: |.:..||
  Rat   259 LAEGAEGPDDAAAPFDADI-DATTTET 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rsph1	NP_609609.1	MORN	51..73	CDD:280628	7/21 (33%)
		MORN	72..93	CDD:197832	8/43 (19%)
		MORN	95..116	CDD:197832	8/20 (40%)
		MORN	118..137	CDD:197832	7/18 (39%)
Jph2	NP_001033063.1	MORN 1. /evidence=ECO:0000255	14..36		8/22 (36%)
		MORN 2. /evidence=ECO:0000255	38..59		7/21 (33%)
		MORN 3. /evidence=ECO:0000255	60..79		7/18 (39%)
		MORN 4. /evidence=ECO:0000255	82..104		1/21 (5%)
		MORN	106..128	CDD:280628	9/21 (43%)
		MORN 5. /evidence=ECO:0000255	106..128		9/21 (43%)
		MORN 6. /evidence=ECO:0000255	129..151		8/23 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..190		9/93 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..273		7/26 (27%)
		MORN 7. /evidence=ECO:0000255	285..307		79/352 (22%)
		MORN	307..327	CDD:197832
		MORN 8. /evidence=ECO:0000255	308..330
		Bipartite nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9ET78	345..359
		Vinculin	<413..>497	CDD:279395
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..661
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9ET78	488..492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900