DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rsph1 and Pms2

DIOPT Version :9

Sequence 1:	NP_609609.1	Gene:	Rsph1 / 34712	FlyBaseID:	FBgn0032478	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	XP_036020772.1	Gene:	Pms2 / 18861	MGIID:	104288	Length:	875	Species:	Mus musculus

Alignment Length:	406	Identity:	84/406 - (20%)
Similarity:	132/406 - (32%)	Gaps:	157/406 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EMSEEDLSAPEEEEDLGPNIGLYIGGRNAAGQRQGRGWAILPNGDQYDGNYRKGRRHGIGVYVFK 69
            |.|||:  ...||..|...|.....|....|..:|.|:|:...|:.|.|.:.:|..||.|.|::.
Mouse    65 EQSEEE--TQYEEPILTKLIVESYEGEKVRGLYEGEGFAVFQGGNTYHGMFSEGLMHGQGTYIWA 127

  Fly    70 DGSRY----------------------------------YGQYRC-------------GKRCGR- 86
            ||.:|                                  :|.::|             |||.|:
Mouse   128 DGLKYEGDFVKNIPMNHGVYTWPDGSTYEGEVTNGMRNGFGMFKCGTQPVSYIGHWCHGKRHGKG 192

  Fly    87 ------------------------GIFIYPDGSVYEGNWRKNLKHGKGRYKYV-NGDNYSGDWFK 126
                                    ||..|..|::|||.|..|::||:||.::: ..:.|:|.|.|
Mouse   193 SIYYNQEGTSWYEGDWVYNIKKGWGIRCYKSGNIYEGQWENNMRHGEGRMRWLTTNEEYTGHWEK 257

  Fly   127 ---------------------------------GQRHGVGIYHFNSGKDGCCLSVRMKATWNSNM 158
                                             |.|||.|.:::.||       ...:..|.||.
Mouse   258 GIQNGFGTHTWFLKRIPNSQYPLRNEYIGEFVNGFRHGQGKFYYASG-------AMYEGEWASNK 315

  Fly   159 RTGPFELYIGNEDKCTILHG-IWDNLYPSGPAVFSFNNRYLLLGYFLPASYNMKAISNEDEMEDA 222
            :.|        ..:.|..:| :::.|         |:|.::...:.....|:...    |...||
Mouse   316 KQG--------RGRMTFKNGHVYEGL---------FSNDHIAQFFETEMDYSQSL----DRWSDA 359

  Fly   223 EERLEDEMGEAEPMEPTLWFAQEMAVYDFSLLPQEPVPLAISDSELSVCSLSTEPSMRSEEKISW 287
            .:|.....|           :...||       :||..|...|...|...|.|...:.....:..
Mouse   360 SQRSRQPRG-----------SSVSAV-------REPETLRKLDGSESRSVLGTSIELDLTLLLDM 406

  Fly   288 YGEGEEAEGEEGGEME 303
            |  .||::.||..::|
Mouse   407 Y--PEESQEEEKKQVE 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rsph1	NP_609609.1	MORN	51..73	CDD:280628	9/21 (43%)
		MORN	72..93	CDD:197832	10/92 (11%)
		MORN	95..116	CDD:197832	9/21 (43%)
		MORN	118..137	CDD:197832	9/51 (18%)
Pms2	XP_036020772.1	PLN03185	106..>405	CDD:215619	65/344 (19%)
Pms2	XP_036020772.1	vATP-synt_E	782..>829	CDD:419987
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1309439at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910