DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5439 and MDM1

DIOPT Version :9

Sequence 1:	NP_609607.1	Gene:	CG5439 / 34710	FlyBaseID:	FBgn0032476	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_013603.1	Gene:	MDM1 / 854867	SGDID:	S000004572	Length:	1127	Species:	Saccharomyces cerevisiae

Alignment Length:	559	Identity:	107/559 - (19%)
Similarity:	198/559 - (35%)	Gaps:	146/559 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RRLQESAHKISQK--FSGKELATERDESVQE-------------LCESLEELMSYGLRQSAGTSS 85
            :||..|.:.|..|  |.|.|:.|...:..:|             |.|....|.|..|:.....|.
Yeast   372 KRLLLSLNLIESKLSFPGSEIDTASKKLAREANYPDLNMDNGIVLKEMASFLTSITLKDIVDDSE 436

  Fly    86 FSA--ASFIQNMQEMVSGNAGGGSNNNDATFWEFCQT---------------HLTPHERQRYMDL 133
            |..  .||:.::.|           ...:||.|:.||               .::.:.....|.|
Yeast   437 FLPFFESFLGSVPE-----------TQGSTFLEYSQTIESFKNPLEDATSEDIISGYSGISTMQL 490

  Fly   134 KQIWTNVGRGRAFIRATLNEKRLHSHVLTW-----LSDEEQLHRFYTPWSLLLNDEAA------- 186
            ::|.:............|.::.|..:::.:     ::::|..........|||..||.
Yeast   491 QEISSKFFHNNNLQNMKLLDEGLVKNIILFRNSFQINNDEDTFILARKSVLLLQTEAIKYLDDRF 555

  Fly   187 ----KKLPEIVDSLSDVLFALNVDTTEL-----------NAPRRSTPSVAVKEEPIIFTTSPVPV 236
                ||.|..:..||    ..::.:|::           |.|.::.   .:|:.......:||.:
Yeast   556 LPLFKKTPSFLKMLS----TSHIISTDIYAHFLSRIGGVNNPEQNK---IIKDNVKTDFMNPVRI 613

  Fly   237 VGRQKRPGI--AVERPIECVSSTEDLLGALKPIESVEVQQILSKESIEQELAQPQEEVNLGPFDP 299
            ..   .|||  |::..:....|        ||.:|    :|.|.....|......:.:
Yeast   614 FA---NPGITDALDNIVNGSGS--------KPHKS----RISSNPRYSQLFGSENDNI------- 656

  Fly   300 IEPELEFLKTPLPDIGAHVGESELYEDRSDTSSQWSK-SSSSANCLANSQQ----------QAAL 353
                  |......|...:..|..:.||:.|......| |.||.|...|..|          .|:|
Yeast   657 ------FKDKLFDDENDNTSEISVVEDQLDHPRNMEKVSVSSGNSGLNPSQFYGSNNFRDNIASL 715

  Fly   354 EEHVNQLNERCALLETRVAELSLQNRLLIRRLTKQFEET---GIDPSSSLCSNFLI--------- 406
            ...::|:.:...||...:.:..|.|..:..::.|:.:.|   .::....|...:::
Yeast   716 TISIDQIEKELELLRHLILKADLTNNQMQLKILKKSQRTLLKELEMKELLKQQYMVQENGNSLFR 780

  Fly   407 -TIPHVKLAKTQRSG------SHYTYEVHITMRQRLEHWTFFRRYSEFYKLHKSLLKT-HPVVSA 463
             |..:::...::.|.      ::|...:|.....::..|...|||:||::|:..|.|. ..::..
Yeast   781 KTKIYIRSYFSENSSNGLKEITYYIINIHHFNNGQVSSWDMARRYNEFFELNTYLKKNFRDLMRQ 845

  Fly   464 VE--FPPK-----KHFGNMNLVFVEERRQQLQIYLLNLV 495
            ::  ||.|     |:.....|:: |||:|:|:.||..|:
Yeast   846 LQDLFPSKVKMSLKYHVTKTLLY-EERKQKLEKYLRELL 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5439	NP_609607.1	RUN	64..206	CDD:280855	32/187 (17%)
CG5439	NP_609607.1	PX_RUN	404..520	CDD:132810	26/116 (22%)
MDM1	NP_013603.1	PXA	85..276	CDD:214611
		RGS	462..567	CDD:413378	15/104 (14%)
		PX_MDM1p	763..900	CDD:132786	27/122 (22%)
		Nexin_C	993..1106	CDD:400794
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900