Protein Alignment CG5439 and SNX25

DIOPT Version :9

• Sequence 1: NP_609607.1
• Gene: CG5439 / 34710
• FlyBaseID: FBgn0032476
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001364961.1
• Gene: SNX25 / 83891
• HGNCID: 21883
• Length: 1037
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 114/641 - (17%)
• Similarity: 221/641 - (34%)
• Gaps: 192/641 - (29%)

  Fly    32 EDIFRRLQESAHKISQKFSGKELATERDESVQELCESLEELMSYGLRQSAGTSSFSAASFIQNMQ 96
            ||.:...::..|::|.....|.:.   ::.|:.|.....:|.:...|.......|...:.::|
Human   201 EDFWEIARQLHHRLSHVDVVKVVC---NDVVRTLLTHFCDLKAANARHEEQPRPFVLHACLRN-- 260

  Fly    97 EMVSGNAGGGSNNNDATFWEFCQTHLT----PHERQRYMDLKQIWTNVGRGRAF---IRATLNEK 154
                       ::::..|.:.|...|.    |.:..:.:.|:.:...:...:..   :....|..
Human   261 -----------SDDEVRFLQTCSRVLVFCLLPSKDVQSLSLRIMLAEILTTKVLKPVVELLSNPD 314

  Fly   155 RLHSHVLTWLSDEEQLH----RFYT------PWSLLLND----EAAKKLPEIVDSLSDVLFALNV 205
            .::..:|..|:..||::    |.||      .:..|:|.    |..|:|.|.|.:.:.::...|.
Human   315 YINQMLLAQLAYREQMNEHHKRAYTYAPSYEDFIKLINSNSDVEFLKQLRESVQTSALLILEPNS 379

  Fly   206 DTTELNAPRRSTPSVAVKEEPII-----FTTSPVPVVGRQKRPGIAV------------------ 247
            ...:...|......|:.:.:.::     .|.|..|.:.|.|....|.
Human   380 ALAKSYPPLEKENRVSARYQIVVEIIQATTISSFPQLKRHKGKETAAMKADLLRARNMKRYINQL 444

  Fly   248 -------ERPIECV-----SSTEDLLGALKPIESVEVQQILSKESI------EQELAQPQEEVN- 293
                   |:.|..:     ...||  |||...|..:.|:||..|.|      .:......|.::
Human   445 TVAKKQCEKRIRILGGPAYDQQED--GALDEGEGPQSQKILQFEDILANTFYREHFGMYMERMDK 507

  Fly   294 ---LGPFDPIEPELEFLKTPLPDIGAHVGE----------------------------------- 320
               :..::.:|......|..:|.:   |||
Human   508 RALISFWESVEHLKNANKNEIPQL---VGEIYQNFFVESKEISVEKSLYKEIQQCLVGNKGIEVF 569

  Fly   321 ----SELYEDRSD-------TSSQWSK------SSSSANCLANSQQ--------QAALEEHVNQL 360
                .::||...|       .|..:.|      ...::..::|..:        :.|:::..||:
Human   570 YKIQEDVYETLKDRYYPSFIVSDLYEKLLIKEEEKHASQMISNKDEMGPRDEAGEEAVDDGTNQI 634

  Fly   361 NERCALLETRVAEL------------SLQN-----RLLIRRLTKQF-----EETGID----PSSS 399
            ||:.:....::.||            |:||     :.::.:|..:.     |.|.:.    .:..
Human   635 NEQASFAVNKLRELNEKLEYKRQALNSIQNAPKPDKKIVSKLKDEIILIEKERTDLQLHMARTDW 699

  Fly   400 LCSNF-----LITIPHVKLAKTQRSGSHY-TYEVHITMRQ----RLEHWTFFRRYSEFYKLHKSL 454
            .|.|.     .||...|    |:.:|... .|.|.:::::    ..::||..||.|||..||:.|
Human   700 WCENLGMWKASITSGEV----TEENGEQLPCYFVMVSLQEVGGVETKNWTVPRRLSEFQNLHRKL 760

  Fly   455 LKTHPVVSAVEFP--PKKHFGNMNLVFVEERRQQLQIYLLNLVETLPQVEACKSKA 508
            .:..|.:..|:.|  .|..|.:::..|:|:.:.||..:|.||   |.....|:|:|
Human   761 SECVPSLKKVQLPSLSKLPFKSIDQKFMEKSKNQLNKFLQNL---LSDERLCQSEA 813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5439	NP_609607.1	RUN	64..206	CDD:280855	26/162 (16%)
		PX_RUN	404..520	CDD:132810	33/117 (28%)
SNX25	NP_001364961.1	PXA	166..321	CDD:396666	17/135 (13%)
		235kDa-fam	<331..>691	CDD:130673	58/364 (16%)
		RGS_SNX25	488..596	CDD:188675	12/110 (11%)
		PX_SNX25	699..821	CDD:132788	35/122 (29%)
		Nexin_C	898..1004	CDD:400794

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900