DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5439 and RUFY1

DIOPT Version :9

Sequence 1:	NP_609607.1	Gene:	CG5439 / 34710	FlyBaseID:	FBgn0032476	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_079434.3	Gene:	RUFY1 / 80230	HGNCID:	19760	Length:	708	Species:	Homo sapiens

Alignment Length:	451	Identity:	97/451 - (21%)
Similarity:	175/451 - (38%)	Gaps:	113/451 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 DLKQIWTNVGRGRAFIRATLNEKRLHSHVLTWLSDEEQLHRFYTPWSLLLNDEAAKKLPEIVDSL 196
            :|.::.|.||||||::...|.:|:|..::...:.::..|..||.|.:|::.:|..
Human   196 NLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGM---------- 250

  Fly   197 SDVLFALNVDTTELNAPRRSTPSVAVKEEPIIFTTSPVPVV-------GRQKRPGIAVERPIECV 254
              |:..|.|....|:|      ::.:|.|.:   .|.|.|:       ..|...|......|..|
Human   251 --VIVGLLVGLNVLDA------NLCLKGEDL---DSQVGVIDFSLYLKDVQDLDGGKEHERITDV 304

  Fly   255 SSTEDLLGALKPIESVEVQQILSK-ESIEQELAQPQEEVNLGP--FDPIEPELEFLKTPLPDIGA 316
            ...::.:..|....|..|..:.:| :.:|:..::.|||::...  ...::.|.:.|:.
Human   305 LDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLRE------- 362

  Fly   317 HVGESELYEDRSDTSSQWSKSSSSANCLANSQQQAALEEHVNQLNERCALLETRVAELSLQNRL- 380
               ::||..:||:.|.:.:|..:........|.:..|:|..:.:.::  |.|.:...|.|:..|
Human   363 ---QNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQ--LKEEKKVRLELEKELE 422

  Fly   381 --------------LIRRLTKQFEETGIDPSSSL-------------CSNFLITIPHVKLAKTQR 418
                          |:.:.|.:.::|.:.....|             ..|...::.....|.|..
Human   423 LQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSF 487

  Fly   419 SGSHYTYEVHITMRQ---RLEHWTFFRRYSE--FYKLHK-----------SLLKTHPVVSAVEFP 467
            .|.  |.:|..:|:|   ||:|....|:.:|  .:||.:           .|.:.|...|::|..
Human   488 EGK--TNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKE 550

  Fly   468 PKKHFGNMNLVFVEERRQQLQIYLLNLVET-------LPQVEACK--------SKAELQKV 513
            .|..         :|:||.||..|.:..:|       |.|||..|        .||||||:
Human   551 LKSE---------KEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKI 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5439	NP_609607.1	RUN	64..206	CDD:280855	19/73 (26%)
CG5439	NP_609607.1	PX_RUN	404..520	CDD:132810	37/141 (26%)
RUFY1	NP_079434.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..57
		RUN	147..270	CDD:280855	22/91 (24%)
		DUF4201	451..612	CDD:290581	39/163 (24%)
		AAA_23	<486..601	CDD:290211	33/125 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	493..522		8/28 (29%)
		Interaction with RAB4. /evidence=ECO:0000250	615..625
		FYVE_RUFY1	634..704	CDD:277297
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4381
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900