DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5439 and Plekhm2

DIOPT Version :9

Sequence 1:	NP_609607.1	Gene:	CG5439 / 34710	FlyBaseID:	FBgn0032476	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001028322.1	Gene:	Plekhm2 / 69582	MGIID:	1916832	Length:	1033	Species:	Mus musculus

Alignment Length:	394	Identity:	81/394 - (20%)
Similarity:	148/394 - (37%)	Gaps:	85/394 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 REDIFRRLQESAHKISQKFSGKELAT----ERDESVQELCESLEELMSYGLRQSAGTSSFSAASF 91
            ::.|...:..|..|:...|:..|..|    ..|:.:|.|||.|:..:.|||
Mouse     7 KDRILENISLSVKKLQSYFAACEDETPAIRNHDKVLQRLCEHLDHALLYGL-------------- 57

  Fly    92 IQNMQEMVSGNAGGGSNNNDATFWEFCQTHLTPHERQRYMD-LKQIWTNVGRGRAFIRATLNEKR 155
                |::.||            :|... .|.|..|..|.:: |:.:.||:||.||::...|||..
Mouse    58 ----QDLSSG------------YWVLV-VHFTRREAIRQIEVLQHVATNLGRSRAWLYLALNENS 105

  Fly   156 LHSHVLTWLSDEEQLHRFYTPWSLLLNDEAAKKLPEIVDSLSDVLFALNVDTTELN----APRRS 216
            |.|::..:..:...|.::|...:|:.:.:.......:|..|..:.|.|::|...|:    .|...
Mouse   106 LESYLRLFQENLGLLQKYYVRNALVCSHDHLTLFLTLVSGLEFIRFDLDLDAPYLDLAPYMPDYY 170

  Fly   217 TPSVAVKEEPIIFTTSPVPVVGRQKRPGIAVERPIECVSSTEDLLGALKPIESVEVQQILSKESI 281
            .|...:..|                      :|....|..::.|  :|....||....:   |..
Mouse   171 KPQYLLDFE----------------------DRLPSSVHGSDSL--SLNSFNSVTSTNL---EWD 208

  Fly   282 EQELAQPQEEVNLG---PFDPIEPELEFLKTPLPDI--GAHVGESELYEDRSDTSS--------- 332
            :..:|...|:.:.|   |..|..|..::....|.|.  |.....|:|...::.|.|
Mouse   209 DSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGDLTDTISGPRSTASDLTSSKTSTKSPTQRHNPFN 273

  Fly   333 -QWSKSSSSANCLANSQQQAALEEHVNQLNERCALLETRVAELSLQNRLLIRRLTKQFEETG-ID 395
             :.::::||.....::..|...|.......:.|..||  |..::.:.::..::.||..|:.. :.
Mouse   274 EEQAETASSDTTPVHTTSQEKEEAQAPDQPDACTELE--VIRVTKKKKIGKKKKTKLDEDASPLH 336

  Fly   396 PSSS 399
            |:||
Mouse   337 PTSS 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5439	NP_609607.1	RUN	64..206	CDD:280855	34/142 (24%)
CG5439	NP_609607.1	PX_RUN	404..520	CDD:132810
Plekhm2	NP_001028322.1	RUN	93..156	CDD:214736	14/62 (23%)
		PH	786..887	CDD:278594
		PH_SKIP	787..889	CDD:270119
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4381
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810