DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5439 and SNX14

DIOPT Version :9

Sequence 1:	NP_609607.1	Gene:	CG5439 / 34710	FlyBaseID:	FBgn0032476	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001337461.1	Gene:	SNX14 / 57231	HGNCID:	14977	Length:	967	Species:	Homo sapiens

Alignment Length:	489	Identity:	97/489 - (19%)
Similarity:	177/489 - (36%)	Gaps:	140/489 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 IRATLNEKRLHSHVLTWLSDEEQLHRFYTP--------WSLLLND--EAAKKLPEIVDSLSDV-- 199
            :...|..:|...|.|..|:  |.|..:..|        .:||:.:  ..:..||.: |.|:|.
Human   251 LHVALRSRRDELHYLRKLT--ELLFPYILPPKATDCRSLTLLIREILSGSVFLPSL-DFLADPDT 312

  Fly   200 ---LFALNVDTTELNAPRRSTPSVAVKEEPIIFTTSP-VPVV-----GRQKRPGIAVERPIECVS 255
               |..:.:|.   :.|.::|       ||    .|| ||.:     .|.|:|.: ::..::.:.
Human   313 VNHLLIIFIDD---SPPEKAT-------EP----ASPLVPFLQKFAEPRNKKPSV-LKLELKQIR 362

  Fly   256 STEDLL----GALKPIESVEVQQI-LSKESIEQELAQPQ-------------------------- 289
            ..:|||    ..||...:|.|.|. |:.|.....:.:|:
Human   363 EQQDLLFRFMNFLKQEGAVHVLQFCLTVEEFNDRILRPELSNDEMLSLHEELQKIYKTYCLDESI 427

  Fly   290 ----------EEVNL---GP-------------FDPIEPELEFLKTPLPDIGAHVGE---SELYE 325
                      ||:..   ||             |:..|..|..|:.....:..|..|   ..|..
Human   428 DKIRFDPFIVEEIQRIAEGPYIDVVKLQTMRCLFEAYEHVLSLLENVFTPMFCHSDEYFRQLLRG 492

  Fly   326 DRSDT-SSQWSKSSSSANCLANSQQQAALEEHVNQLNERC-ALLETRVAELSLQNRLLIRRLTKQ 388
            ..|.| :|:.::.|.|.:...|:|::.. ...::::..:. .:.::...|.::.....:......
Human   493 AESPTRNSKLNRGSLSLDDFRNTQKRGE-SFGISRIGSKIKGVFKSTTMEGAMLPNYGVAEGEDD 556

  Fly   389 FEETGI------DPSSSL--------CSNFLITIPHVKLAKTQRSGSH--------YTYEVHITM 431
            |.|.||      .|..::        .:.:.|:||:|...:...|...        :..:|....
Human   557 FIEEGIVVMEDDSPVEAVSTPNTPRNLAAWKISIPYVDFFEDPSSERKEKKERIPVFCIDVERND 621

  Fly   432 RQRL----EHWTFFRRYSEFYKLHKSLLKTHPVVSAVEFPPKKHFGNMNLVFVEERRQQLQIYLL 492
            |:.:    |||:.:|||.|||.|...|.:.|......:.|.|:..|..|..|::.:|::.|.||.
Human   622 RRAVGHEPEHWSVYRRYLEFYVLESKLTEFHGAFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQ 686

  Fly   493 NLVETLPQVEACKSKAE-----------LQKVFP 515
            .|::. |::...:..|:           |.|:.|
Human   687 KLLQH-PELSNSQLLADFLSPNGGETQFLDKILP 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5439	NP_609607.1	RUN	64..206	CDD:280855	16/73 (22%)
CG5439	NP_609607.1	PX_RUN	404..520	CDD:132810	34/135 (25%)
SNX14	NP_001337461.1	PXA	151..320	CDD:308031	16/71 (23%)
		RGS_SNX14	361..487	CDD:188677	21/125 (17%)
		PX_SNX14	585..707	CDD:132787	31/122 (25%)
		Nexin_C	828..932	CDD:312222
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900