DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5439 and RPS6KC1

DIOPT Version :9

Sequence 1:	NP_609607.1	Gene:	CG5439 / 34710	FlyBaseID:	FBgn0032476	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_036556.2	Gene:	RPS6KC1 / 26750	HGNCID:	10439	Length:	1066	Species:	Homo sapiens

Alignment Length:	129	Identity:	35/129 - (27%)
Similarity:	58/129 - (44%)	Gaps:	22/129 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   397 SSSLCSNFLITIPHVKLAKTQRSGSHYT-YEVHITMRQR-----LEHWTFFRRYSEFYKLHKSLL 455
            |:.|...:.:|.|       ||....|| |:|...:..|     ::....::|||:|.||||.|.
Human     8 SADLARFYTVTEP-------QRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELW 65

  Fly   456 KTHPVV--SAVEFPPKKH---FGNMNLVFVEERRQQLQIYLLNLVETLPQVEACKSKAELQKVF 514
            :.|..:  .:..|||...   ||..:...:|||||..:    :|::....:.|..:..:|:..|
Human    66 QIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAE----DLLQFSANIPALYNSKQLEDFF 125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5439	NP_609607.1	RUN	64..206	CDD:280855
CG5439	NP_609607.1	PX_RUN	404..520	CDD:132810	33/122 (27%)
RPS6KC1	NP_036556.2	PX_RPK118_like	11..128	CDD:132820	34/126 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..228
		MIT_SNX15	238..312	CDD:239140
		PKc_like	335..>421	CDD:304357
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..509
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..596
		S_TKc	<875..1056	CDD:214567
		STKc_RPK118_like	<879..1056	CDD:270728
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900