Protein Alignment CG5439 and RUFY3

DIOPT Version :10

• Sequence 1: NP_609607.1
• Gene: CG5439 / 34710
• FlyBaseID: FBgn0032476
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: XP_011530052.1
• Gene: RUFY3 / 22902
• HGNCID: 30285
• Length: 680
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 103/556 - (18%)
• Similarity: 189/556 - (33%)
• Gaps: 188/556 - (33%)

  Fly    62 VQELCESLEELMSYGLRQSAGTSSFSAASFIQNMQEMVSGNAGGGSNNNDATFW---EFCQTHLT 123
            :|:....:|..:.:||:        :..:|:             |.|.   :||   |..: .|.
Human   161 LQQFFVVMEHCLKHGLK--------AKKTFL-------------GQNK---SFWGPLELVE-KLV 200

  Fly   124 PHERQ---RYMDLKQIWTNVGRGRAFIRATLNEKRLHSHVLTWLSDEEQLHRFYTPWSLLLNDEA 185
            |...:   ...||..:.|.||||||::|..|.:|:|..::...::.:|.|..||.|.:|::.:|.
Human   201 PEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEG 265

  Fly   186 A---------------------------------------------------------------- 186
            |
Human   266 AIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEEL 330

  Fly   187 -KKLPEIVDSLSDVLFALNVDTTELNAPRRSTPSVAVKEEPIIFTTSPVPVVGRQ-------KRP 243
             :.|...|::|...:.||....|:|      |..:||....||.....:..|..:       .|.
Human   331 NRHLNATVNNLQAKVDALEKSNTKL------TEELAVANNRIITLQEEMERVKEESSYILESNRK 389

  Fly   244 GIAVERPIE----------CVSSTEDLLGALKPIE---SVEVQQILSKESIEQELAQPQEEV--- 292
            |...:|..|          ....|:..|...|.:|   |:..:..|:.:.:|:::.:.|:.:
Human   390 GPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSL 454

  Fly   293 --NLGPFDPIEPELEFLKTPLPDIGAHVGESELYEDRSDTSSQWSKS----SSSANCLANSQQQA 351
              .|.....::.||.| |....|:|.. .:|||.....:.::|.:.:    .........|:|.|
Human   455 RQQLDDLRALKHELAF-KLQSSDLGVK-QKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSA 517

  Fly   352 ALEEHV--NQLNERCALLETRVAELSLQNRLLIRRLTKQFEETGIDPSSSLCSNFLITIP--HVK 412
            .|:..:  ....::...|:..|.||:.|...|...| ||.:|..:....|        ||  ..:
Human   518 ELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELEL-KQEKERRLQNDRS--------IPGRGSQ 573

  Fly   413 LAKTQRSGSHYTYEVHITMRQRLEHWTFFRRYSEFYKLHKSLLKTHPVVSAVEFPPKKHFGNMNL 477
            .::::..|.|...|.::.:::.||            :.|:  |:.||:
Human   574 KSESKMDGKHKMQEENVKLKKPLE------------ESHR--LQPHPM----------------- 607

  Fly   478 VFVEERRQQLQIYLLNLVETLPQV-EACKSKAELQK 512
                :.:.||      |:...||: :.|:....|.|
Human   608 ----DEQDQL------LLSEKPQLCQLCQEDGSLTK 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5439	NP_609607.1	RUN	37..206	CDD:459241	38/214 (18%)
		PX_RUN	404..520	CDD:132810	19/112 (17%)
RUFY3	XP_011530052.1	PHA03247	<5..100	CDD:223021
		RUN_RUFY3	128..283	CDD:439058	33/146 (23%)
		Smc	<316..>567	CDD:440809	51/267 (19%)
		FYVE_RUFY3	621..668	CDD:277283	3/13 (23%)