DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5439 and Snx25

DIOPT Version :9

Sequence 1:	NP_609607.1	Gene:	CG5439 / 34710	FlyBaseID:	FBgn0032476	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001359271.1	Gene:	Snx25 / 102141	MGIID:	2142610	Length:	986	Species:	Mus musculus

Alignment Length:	413	Identity:	86/413 - (20%)
Similarity:	152/413 - (36%)	Gaps:	112/413 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 ERQRYMDLKQIWTNVGRGRAFIRATLNE--KRLHSHVLT--WLSDEEQLHRFYTPWSLLLNDEAA 186
            :.|:.:..:.|.||     .|.|.....  :|:....|.  |.|.|.            |.:...
Mouse   427 QSQKILQFEDIMTN-----PFYRERFGTYMERIDKRALVGFWESAEH------------LKNANK 474

  Fly   187 KKLPEIVDSLSDVLFALNVDTTELNAPRRSTPSVAVKEEPIIFTTSPVPVVGRQKRPGIAVERPI 251
            .::|::|..:....|   |::.|::.            |..::......:||         .|.|
Mouse   475 SEIPQLVSEMYQNFF---VESKEISV------------EKSLYKEIQQCLVG---------NRGI 515

  Fly   252 ECVSSTEDLLGALKPIESVEVQQILSK--------ESIEQELAQPQEEVNLGPFDPIEPELEFLK 308
            |..|..:           .:|.::|.:        ..:.::|.:.:||.        ||:.: |.
Mouse   516 EVFSKIQ-----------ADVSEVLRERYYPSFLVSDLYEKLMREEEEE--------EPDAQ-LA 560

  Fly   309 TPLPDIGA--HVGESELYEDRSDTSSQWS-----------KSSSSANCLANSQQQAALEEH-VNQ 359
            :...::|:  ..|| |..|..|..|...|           |.......|::.|.....::. :::
Mouse   561 SEKDELGSGGEAGE-EAVEGTSGVSDPASFAVIKLRELNEKLEYKRQALSSIQNAPKPDKKIISK 624

  Fly   360 LNERCALLETRVAELSLQNRLLIRRLTKQFEETGIDPSSSLCSNFLITIPHVKLAKTQRSGSHY- 423
            |.:...|:|.....|.|.    :.|.....|..|:..:|       ||...|    |:.:|...
Mouse   625 LKDEILLIEKECTALQLH----MARTDWWCENLGLWRAS-------ITSAEV----TEENGEQMP 674

  Fly   424 TYEVHITMRQ----RLEHWTFFRRYSEFYKLHKSLLKTHPVVSAVEFP--PKKHFGNMNLVFVEE 482
            .|.|.:.:::    ..::||..||.|||..||:.|.:..|.:..|:.|  .|..|.:::..|:.:
Mouse   675 CYFVRVNLQEVGGVETKNWTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPFKSIDHKFLGK 739

  Fly   483 RRQQLQIYLLNLV--ETLPQVEA 503
            .|.||..:|.||:  |.|.|.||
Mouse   740 SRNQLNAFLQNLLSDERLFQSEA 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5439	NP_609607.1	RUN	64..206	CDD:280855	15/83 (18%)
CG5439	NP_609607.1	PX_RUN	404..520	CDD:132810	34/109 (31%)
Snx25	NP_001359271.1	PXA	148..303	CDD:366970
		RGS	437..545	CDD:383028	25/159 (16%)
		End3	<558..645	CDD:372297	17/92 (18%)
		PX_SNX25	648..770	CDD:132788	37/126 (29%)
		Nexin_C	847..950	CDD:370015
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900