DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5439 and Rubcn

DIOPT Version :9

Sequence 1:	NP_609607.1	Gene:	CG5439 / 34710	FlyBaseID:	FBgn0032476	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_006521715.1	Gene:	Rubcn / 100502698	MGIID:	1915160	Length:	981	Species:	Mus musculus

Alignment Length:	431	Identity:	84/431 - (19%)
Similarity:	147/431 - (34%)	Gaps:	113/431 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 MRSQLAGSTFG----------QRRE--DIFRRLQESAH--------KISQKFSGKELATERDESV 62
            ||.:.||...|          .|||  .:...|:.:..        .:..|:.|          :
Mouse     1 MRPEGAGMDLGGGDGERLLEKSRREHWQLLGNLKTTVEGLVSANCPNVWSKYGG----------L 55

  Fly    63 QELCESLEELMSYGLRQSAGTSSFSAASFIQNMQEMVSGNAGGGSNNNDATFWEFCQ--THLTPH 125
            :.||..::.::.:||                 :.:.|.        ...|.:|:|.:  ..|:||
Mouse    56 ERLCRDMQNILYHGL-----------------IHDQVC--------CRQADYWQFVKDIRWLSPH 95

  Fly   126 ER---QRYMDL---KQIWTNVGRGRAFIRATLNEKRLHSHVLT-----WLSDEEQLHRFYTPWSL 179
            ..   ::::.|   .|..|:....||.....| :..|..|.|:     .|.|.:.:.:|||..:.
Mouse    96 SALHVEKFISLHESDQSDTDSVSERAVAELWL-QHSLQCHCLSAQLRPLLGDRQYIRKFYTETAF 159

  Fly   180 LLND----------EAAKK-LPEIVDSLSDVLFALNVDTTELNAPRRS---------TPSVAVKE 224
            ||:|          ||.:: .|.::..:...:||...::..|....:|         ||..:..:
Mouse   160 LLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKQESPLLVTKSQSLTALPGSTYTPPASYAQ 224

  Fly   225 EPIIFTTS-----PVPVVGRQKR--------PGIAVERPIECVSSTE-DLLGALKPIESVEVQQ- 274
            .....::|     |......::|        |....:...||:|..| ....|..|.:|...|.
Mouse   225 HSYFGSSSSLQSMPQSSHSSERRSTSFSLSGPSWQPQEDRECLSPAETQTTPAPLPSDSTLAQDS 289

  Fly   275 -ILSKESIEQELAQPQE-----EVNLGPFDPIE-PELEFLKTPLPDIGAHVGESELYEDRSDTSS 332
             :.::|..:..|..|.|     ..|..|.|..| ||...:..|.|.  ......|.:....::||
Mouse   290 PLTAQEMSDSTLTSPLEASWVSSQNDSPSDVSEGPEYLAIGNPAPH--GRTASCESHSSNGESSS 352

  Fly   333 QWSKSSSSANCLANSQQQAALEEHVNQLNERCALLETRVAE 373
            ....||||:..|.::......:|...|......|..:..:|
Mouse   353 SHLFSSSSSQKLESAASSLGDQEEGRQSQAGSVLRRSSFSE 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5439	NP_609607.1	RUN	64..206	CDD:280855	33/165 (20%)
CG5439	NP_609607.1	PX_RUN	404..520	CDD:132810
Rubcn	XP_006521715.1	RUN	123..183	CDD:214736	15/60 (25%)
		DUF4679	181..>304	CDD:374056	21/122 (17%)
		APC_basic	204..>426	CDD:368684	39/192 (20%)
		zf-RING_9	747..943	CDD:372797
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4381
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900