DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sfmbt and L3MBTL4

DIOPT Version :9

Sequence 1:	NP_001137821.1	Gene:	Sfmbt / 34709	FlyBaseID:	FBgn0032475	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	XP_011524059.1	Gene:	L3MBTL4 / 91133	HGNCID:	26677	Length:	651	Species:	Homo sapiens

Alignment Length:	701	Identity:	170/701 - (24%)
Similarity:	263/701 - (37%)	Gaps:	231/701 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   535 SYDWLPRLSKENFNAAPVTCF-------PHAPGCEVWDNLGVGMKVEVENTDCDSIEVIQPGQTP 592
            |::|.  |.::...||||..|       .|..|.:      :||:          :|.|.| :.|
Human    53 SWEWY--LKEQKAVAAPVELFSKDQSFPEHENGFQ------IGMR----------LEGIDP-RHP 98

  Fly   593 TSFWVATILEIKGYKALMSYEGFDTDSHDFWVNLCNAEVHSVGWC-ATRGKPLIPPRTIEHKYKD 656
            :.|.|.::.|:.||:..:.::|: ...:|||.|..:.::|.|||| .|:.:..||....:.|:.
Human    99 SVFCVLSVAEVCGYRLRLHFDGY-LSCYDFWTNAGSPDIHPVGWCEKTKHELHIPKGYRKDKFV- 161

  Fly   657 WKDFLVG-RLSGARTLPSN-FYNKI-NDSLQSRFRLGLNLECVDKDRISQVRLATVTKIVGKRLF 718
            |.|:|.. :|..|   |.. |.|:. |..:...|::|:.||.||:...|.|.:||:..||..||.
Human   162 WMDYLKACKLQNA---PKKLFRNRSPNGPMSKEFQVGMKLEAVDRKNPSLVCVATIADIVEDRLL 223

  Fly   719 LRYFDSDDG--FWCHEDSPIIHPVGWATTVGHNLAAPQDYLERMLAGREAMIEVHEDDATIELFK 781
            :.:.:.||.  :||..:||.:.||||....|..|.|||.|
Human   224 VHFDNWDDSYDYWCDVNSPYVQPVGWCQENGRTLIAPQGY------------------------- 263

  Fly   782 MNFTFDEYYSDGKTNSFVEGMKLEAVDPLNLSSICPATVMAVLKFGYMMIRIDSYQPDASGSDWF 846

Human   264 ----------------------------------------------------------------- 263

  Fly   847 CYHEKSPCIFPAGFCSVNNISVTPPNGYDSRTFTWEGYLRDTGAVAAGQHLFHRIIPDHGFEVGM 911
                                    ||   ...|:|..||..|...|....:|...:| |||...|
Human   264 ------------------------PN---PENFSWTEYLEATQTNAVPAKVFKMRLP-HGFLPNM 300

  Fly   912 SLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWLDCESADIYPVGWCVLVNHKLEGPP 976
            .||..|..:|||:.|||:..|..:.:|||||||..:||.|::.:|.||:|:|||.:..|.||.|.
Human   301 KLEVVDKRNPRLIRVATIVDVDDQRVKVHFDGWDHKYDYWVEADSPDIHPIGWCDVTGHPLEVPQ 365

  Fly   977 R-----VAHQQAPKPAPKPK-IQRKRKPKKG---AAGGKTPTDNNTQS-------VKSRTIA-LK 1024
            |     :...||..|.|..: |...|.|:..   :|.|...:|.|.:.       ::.:|.| |:
Human   366 RTNDLKILPGQAVCPTPGCRGIGHIRGPRYSGHHSAFGCPYSDMNLKKEATLHDRLREQTQANLE 430

  Fly  1025 T-TPHLPKLSI-KLELKPEHHNAAFYENNQPE--------EEGDEEDPDADGDGDGSTSHIS--E 1077
            : :.|....|: .|....:|...    |:||.        :...:||.|.|........|..  |
Human   431 SDSSHSKSKSLCSLNFNGKHEKV----NSQPRLVQQAKCLKIKGKEDIDLDNLFRVLVLHPRGLE 491

  Fly  1078 QSTTQSSSDLIAGSGSGSGSASLVTLATGSNKTVKKSTTKSPAPP----TVGRKATSYIANSSAT 1138
            .|..|:...|                    :::|..||..  |.|    .:||:          .
Human   492 YSVEQAQQVL--------------------HQSVSMSTVS--AHPFRDLPLGRE----------Q 524

  Fly  1139 NNKYIPRLADIDSSEPHLELVPDTWNVYDVSQFLR-VNDCTAHCDTFSRNK 1188
            :.|.:|.:|||.:|:      ...|.|.:|::|:: :..|..|...|.:.:
Human   525 HCKLLPGVADIRASQ------VARWTVDEVAEFVQSLLGCEEHAKCFKKEE 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT	542..647	CDD:214723	31/112 (28%)
		MBT	658..753	CDD:214723	34/99 (34%)
		MBT	767..871	CDD:214723	0/103 (0%)
		MBT	882..975	CDD:214723	40/92 (43%)
		TonB_N	<975..1040	CDD:292650	19/83 (23%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979	7/30 (23%)
		SAM	1160..1224	CDD:197735	7/30 (23%)
L3MBTL4	XP_011524059.1	MBT	57..149	CDD:214723	30/111 (27%)
		MBT	164..260	CDD:214723	34/98 (35%)
		MBT	273..364	CDD:214723	40/91 (44%)
		zf-C2HC	379..405	CDD:279824	7/25 (28%)
		SAM_superfamily	540..>569	CDD:301707	7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149826
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3766
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740