DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sfmbt and L3MBTL3

DIOPT Version :9

Sequence 1:	NP_001137821.1	Gene:	Sfmbt / 34709	FlyBaseID:	FBgn0032475	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	XP_006715639.1	Gene:	L3MBTL3 / 84456	HGNCID:	23035	Length:	815	Species:	Homo sapiens

Alignment Length:	1048	Identity:	224/1048 - (21%)
Similarity:	361/1048 - (34%)	Gaps:	327/1048 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 MGTLNG-------NAFGNIMVSTENTSSKQMQRTYSTAKGANSTATTA----------------- 277
            :|||.|       |.||.:.|.|:....:.:::..:|......||..|
Human    25 VGTLPGSDLKFRVNEFGALEVITDENEMENVKKATATTTWMVPTAQEAYTGDLAKSLPLFFSSTP 89

  Fly   278 ---------TCSASTSSALRSQRKTRKIEP----VNRPGLVL----KTPIAYRGNIDPSVIPIQK 325
                     ....|||.|..|...:|.:.|    .:.||...    ||.:.:|     ...|::.
Human    90 MVVTNTYMLMTPKSTSPAPTSPPSSRPVFPPAYWTSPPGCPTVFSEKTGMPFR-----LKDPVKV 149

  Fly   326 DGMAVCKRCGAIG-VKHTFYTKSRRFCSMACARGELYSLVLNTKMEGDQATTSSPDPGAGSESAD 389
            :|:..|:.|...| |....  ....:||..|||                               .
Human   150 EGLQFCENCCQYGNVDECL--SGGNYCSQNCAR-------------------------------H 181

  Fly   390 LPGDQQQSQSDIELDLHAAHIKNANYRFRITDQSKITQLNSFGEPMSMGGDAAANNVQMAADETI 454
            :....|:.:.|:|.|......|        ..:.|..:|:...:...   |....:.:|...:.:
Human   182 IKDKDQKEERDVEEDNEEEDPK--------CSRKKKPKLSLKADTKE---DGEERDDEMENKQDV 235

  Fly   455 AALNGGAVGDATAPGSTEEGASTPNSYLSAAPTPKALRLFKDIYPQDDLPQIPKYERLPVPC--- 516
            ..|.|.........|.        ::.|.....||..:.:                     |
Human   236 RILRGSQRARRKRRGD--------SAVLKQGLPPKGKKAW---------------------CWAS 271

  Fly   517 -PQMEKIISIRRRMYDPTHSYDWLPRLSKENFNAAPVTCFPHAPGCEVWDNLGVGMKVEVENTDC 580
             .:.||.:::..:::....|:.:    :|..|.                    ||||:|..:.:.
Human   272 YLEEEKAVAVPAKLFKEHQSFPY----NKNGFK--------------------VGMKLEGVDPEH 312

  Fly   581 DSIEVIQPGQTPTSFWVATILEIKGYKALMSYEGFDTDSHDFWVNLCNAEVHSVGWCATRGKPLI 645
            .|:           :.|.|:.|:.||:..:.::|: :|.:|||||....::|.||||...|..|.
Human   313 QSV-----------YCVLTVAEVCGYRIKLHFDGY-SDCYDFWVNADALDIHPVGWCEKTGHKLH 365

  Fly   646 PPRTIEHKYKDWKDFLVGRLSGARTLPSNFYNKINDS-LQSRFRLGLNLECVDKDRISQVRLATV 709
            ||:..:.:..:|:.:|  :...|:..|.:.:...|.: :.|.||:|:.||.|||...|.:.:|||
Human   366 PPKGYKEEEFNWQTYL--KTCKAQAAPKSLFENQNITVIPSGFRVGMKLEAVDKKNPSFICVATV 428

  Fly   710 TKIVGKRLFLRYFDSDD---GFWCHEDSPIIHPVGWATTVGHNLAAPQDYLERMLAGREAMIEVH 771
            |.:|..| ||.:||:.|   .:||...||.||||||
Human   429 TDMVDNR-FLVHFDNWDESYDYWCEASSPHIHPVGW----------------------------- 463

  Fly   772 EDDATIELFKMNFTFDEYYSDGKTNSFVEGMKLEAVDPLNLSSICPATVMAVLKFGYMMIRIDSY 836

Human   464 ----------------------------------------------------------------- 463

  Fly   837 QPDASGSDWFCYHEKSPCIFPAGFCSVNNISVTPPNGYDSRTFTWEGYLRDTGAVAAGQHLFHRI 901
                      |...:...|.|.|:.:|.:             |:|:.||.:|.::.|....| ::
Human   464 ----------CKEHRRTLITPPGYPNVKH-------------FSWDKYLEETNSLPAPARAF-KV 504

  Fly   902 IPDHGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWLDCESADIYPVGWCV 966
            .|.|||:..|.||..|..:|..:.|||||......:|||||||.:.||.|:|.:|.||:|||||.
Human   505 KPPHGFQKKMKLEVVDKRNPMFIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPVGWCS 569

  Fly   967 LVNHKLEGP-------PRVAHQQAPKPAPKPKIQRKRKPKKGAAGGKTPTDNNTQSVKSRTIALK 1024
            ...|.|:.|       ....|.....|..|.....||....|.........:.....|.|....:
Human   570 KTGHPLQPPLSPLELMEASEHGGCSTPGCKGIGHFKRARHLGPHSAANCPYSEINLNKDRIFPDR 634

  Fly  1025 TTPHLPKLSIKLELKPEHHNAAFYENNQPEEEGDEEDPDADGDGDGSTSHISEQSTTQSSSDLIA 1089
            .:..:|..|...   |.:......|::...|..|:...|...|.:..|.  ||..|
Human   635 LSGEMPPASPSF---PRNKRTDANESSSSPEIRDQHADDVKEDFEERTE--SEMRT--------- 685

  Fly  1090 GSGSGSGSASLVTLATGSNKTVKKSTTKSPAP--PTVGRKATSYIANSSATNNKYIPRLADIDSS 1152
             |....|:....|:.....::....:.|||.|  |....:           .:|.:|.:|.|.:|
Human   686 -SHEARGAREEPTVQQAQRRSAVFLSFKSPIPCLPLRWEQ-----------QSKLLPTVAGIPAS 738

  Fly  1153 EPHLELVPDTWNVYDVSQFLR-VNDCTAHCDTFSRNKIDGKRLLQLTKDDIMPLLGMKVGPALKI 1216
            :      ...|:..:||:|:: :..|..|...|...:|||:..|.:|:.||:.::.:|:||||||
Human   739 K------VSKWSTDEVSEFIQSLPGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKI 797

  Fly  1217 SDLIAQLK 1224
            .:.|...|
Human   798 FNSILMFK 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT	542..647	CDD:214723	27/104 (26%)
		MBT	658..753	CDD:214723	35/98 (36%)
		MBT	767..871	CDD:214723	5/103 (5%)
		MBT	882..975	CDD:214723	40/92 (43%)
		TonB_N	<975..1040	CDD:292650	11/71 (15%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979	23/66 (35%)
		SAM	1160..1224	CDD:197735	22/64 (34%)
L3MBTL3	XP_006715639.1	MBT	271..367	CDD:214723	30/131 (23%)
		MBT	380..474	CDD:214723	37/200 (19%)
		MBT	486..578	CDD:214723	40/92 (43%)
		zf-C2HC	592..619	CDD:279824	5/26 (19%)
		SAM	740..806	CDD:197735	23/66 (35%)
		SAM_Scm-like-3MBT3,4	740..805	CDD:188981	22/64 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149805
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840