DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sfmbt and scml2

DIOPT Version :9

Sequence 1:	NP_001137821.1	Gene:	Sfmbt / 34709	FlyBaseID:	FBgn0032475	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	XP_012812742.2	Gene:	scml2 / 780057	XenbaseID:	XB-GENE-6043728	Length:	706	Species:	Xenopus tropicalis

Alignment Length:	803	Identity:	185/803 - (23%)
Similarity:	294/803 - (36%)	Gaps:	226/803 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   541 RLSKENFN-----------AAPVTCFPHA---PGCEVWDNLGVGMKVEVENTDCDSIEVIQPGQT 591
            :.:||.||           |||..||..:   |.    ::..||||:|..:.           :.
Frog     8 KTAKEKFNWDDYLNQVGSVAAPPNCFKQSRTPPS----NDFKVGMKLEAHDP-----------RN 57

  Fly   592 PTSFWVATILEIKGYKALMSYEGFDTDSHDFWVNLCNAEVHSVGWCATRGKPLIPPRTIEHKYKD 656
            .||..:||::.|.|.:..:..:|.| |.:|||..:.:.::..:|.|..:|..|.||.........
Frog    58 ITSICIATVVGITGARLRLRLDGSD-DKNDFWRLVDSCDIQQIGTCEKKGDMLQPPLGFRMNASS 121

  Fly   657 WKDFLVGRLSGARTLP-SNFYNKINDSLQSRFRLGLNLECVDKDRISQVRLATVTKIVGKRLFLR 720
            |..||:..|:||...| :.|..:.....||.|:.|:.||.|||.....:..||:..:.|..:|:.
Frog   122 WPMFLLKTLNGADMAPITCFKQEPQKPSQSFFKTGMKLEAVDKKNPYLICPATIGDVKGDDIFIT 186

  Fly   721 Y------FDSDDGFWCHEDSPIIHPVGWATTVGHNL-----------------AAPQDYLERML- 761
            :      ||    :||..||..|.|:||.:..|.:|                 |:|...:.|.:
Frog   187 FDGWRGAFD----YWCKYDSRDIFPIGWCSLTGDSLQPPGNSVSLPRTSSTPTASPIKGVRRSMQ 247

  Fly   762 ---------AGREAMIE--VHEDDATIELFK--MNFTFD------EYYSDGKTNSFVEGMKLEAV 807
                     .||:.|.:  :.:..|:....|  .|.|..      |..:..|......|.|.|.:
Frog   248 SPQKPVQAQKGRKPMRDKCLGQTSASPRKGKRPKNTTLSRNTPNAENQTKSKGTGLKPGRKKETL 312

  Fly   808 DPLNLSSICPATV-------MAVLKFGYMMIRIDSYQPDASGSDWFCYHEKSPCIFPAGFCSVNN 865
             .|| ||:.|...       ..:||.|..::                   .||....:..|.
Frog   313 -ALN-SSLPPVNTSDGDSNKSQILKDGVGIL-------------------GSPVAVISTVCV--- 353

  Fly   866 ISVTPPNGYDSRTFTWEGYLRDTGAVAAGQHLFHRII---PDH---GFEVGMSLE-----CADLM 919
                              |:...|  .:|.||..:.:   |||   | .|.:.|:     |.|
Frog   354 ------------------YVNKHG--NSGPHLDKKKVLQLPDHFGPG-PVNVVLQQAVQACVD-- 395

  Fly   920 DPRLVCVATVARVV----------GRLLKVHFDGWTDEYDQWLDCESADIYPVGWCVLVNHKLEG 974
                 | |..:::|          |..:...|||         :..|..:.||.....|...||
Frog   396 -----C-AYYSKIVFSFLKSGHHGGEAITASFDG---------EKHSVHLPPVNSASFVLRFLE- 444

  Fly   975 PPRVAHQQ------APKPAPKPKIQRKRKPKKGAAGGKTPTDNNTQSVKSRTIALKT-------- 1025
              ::.|..      :.:|.         .|..|  |..:|||.:........|..::
Frog   445 --KLCHSLQCDNLFSSQPF---------SPHMG--GAHSPTDYDRSKTTKEEITDRSNKRYCQDP 496

  Fly  1026 -------TPHLPKLSIKLELKPEHHNAAFYENNQPEEEGDEEDPDADGDGDGSTSHISEQSTTQS 1083
                   :|.||:..:.   .||...:...||..|:::...|:.........:|:..:.::||:
Frog   497 PPFSAPLSPKLPRSEVH---PPEAEMSPTEENCMPKDQRFSEESMDSALNTVNTASPATRNTTE- 557

  Fly  1084 SSDLIAGSGSGSGSASLVTLATGSNKTVKKSTTKSPAPPTVGRKATSYIANSSATNNKYIPRLAD 1148
            ..::.|.|....||...||..:.....|::|::.|.:       .:.|..:|.....:.|...:.
Frog   558 YRNMGATSAYYRGSVQPVTATSNGAPVVRRSSSSSAS-------NSCYYDSSRNRTQRRIEAASS 615

  Fly  1149 IDSSEPH---------LELVPDTWNVYDVSQFLRVNDCTA---HCDTFSRNKIDGKRLLQLTKDD 1201
            ....|.|         |...|.||:|.||..|::..|..|   |.:.|.|::|||..||.|..|.
Frog   616 TTGPELHSTERQTTQSLSKDPATWSVDDVMCFVKEADPQALAPHAELFRRHEIDGTALLLLRSDM 680

  Fly  1202 IMPLLGMKVGPALKISDLIAQLK 1224
            ||..:|:|:|||||:...|.:||
Frog   681 IMKYMGLKLGPALKLCYHIERLK 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT	542..647	CDD:214723	31/118 (26%)
		MBT	658..753	CDD:214723	33/118 (28%)
		MBT	767..871	CDD:214723	21/120 (18%)
		MBT	882..975	CDD:214723	26/113 (23%)
		TonB_N	<975..1040	CDD:292650	12/85 (14%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979	31/68 (46%)
		SAM	1160..1224	CDD:197735	29/66 (44%)
scml2	XP_012812742.2	MBT	17..112	CDD:214723	27/110 (25%)
		MBT	123..221	CDD:214723	32/101 (32%)
		RBR	255..316	CDD:407329	14/62 (23%)
		SLED	350..459	CDD:403384	28/152 (18%)
		SAM_Scm	633..704	CDD:188977	31/71 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910