DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sfmbt and Sfmbt1

DIOPT Version :9

Sequence 1:	NP_001137821.1	Gene:	Sfmbt / 34709	FlyBaseID:	FBgn0032475	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_113835.2	Gene:	Sfmbt1 / 58967	RGDID:	61999	Length:	863	Species:	Rattus norvegicus

Alignment Length:	880	Identity:	224/880 - (25%)
Similarity:	332/880 - (37%)	Gaps:	236/880 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   536 YDWLPRLSKENFNAAPVTCFPHAPGCEVWDNLGVGMKVEVENTDCDSIEVIQPGQTPTSFWVATI 600
            :.|...|.:.....||...|.|...| :......|||:||...           :.|.::||||:
  Rat    20 FSWEDYLEETGATTAPYASFKHVDIC-LQSGFAPGMKLEVALR-----------KDPETYWVATV 72

  Fly   601 LEIKGYKALMSYEGFDTD-SHDFWVNLCNAEVHSVGWCATRGKPLIPPRTIEHKYKDWKDFLVGR 664
            :.......|:.|||:..| ..|||.::..|.::.:|||....|.|..|..|..|..||..||...
  Rat    73 ITACEQLLLLRYEGYGEDRKADFWCDIRRAGLYPIGWCQQNKKTLEAPEGIRDKVSDWSAFLQRT 137

  Fly   665 LSGARTLPSNFYNKINDSLQSRFRLGLN----------LECVD-KDRISQVRLATVTKIVGKRLF 718
            |:||...|.        :|....|.|.|          |||.| :|.:| ..:.||.:.:|.||.
  Rat   138 LTGACGPPV--------ALLEGLRNGRNPLDLIAPGSRLECQDFRDSVS-TWIVTVVENIGGRLK 193

  Fly   719 LRY--FDSDDGF--WCHEDSPIIHPVGWATTVGHNLAAPQ--DYLERMLAGREAMIEVHEDDATI 777
            |:|  .:..|||  |.:...|.:|.:|||...|:.|..|.  .:|:.....:|.:..|.|::...
  Rat   194 LQYEGLERHDGFEHWLYYLDPFLHHIGWAAQQGYELQPPLAIRHLKNEADWQEILARVKEEEPLP 258

  Fly   778 E-LFKMNFTFDEYYSDGKTNSFVEGMKLEAVDPLNLSSICPATVMAVLKFGYMMIRIDSYQPDAS 841
            . |||.....       :|:.|...||||||||.:...|.|||:..|....|.::.||..:|:..
  Rat   259 SYLFKDKQVI-------RTHEFSINMKLEAVDPWSPFGISPATIAKVFDDKYFLVEIDDLRPEDH 316

  Fly   842 GSDWFCYHEKSPCIFPAGFCSVNNISVTPPNGYDSRTFTWEGYLRDTGAVAAGQHLFHRIIPDHG 906
            ....|..|..||.|||..:...|.:.:.||.|:.|:.|.|..||:..||.||.|..|.:.:.:|.
  Rat   317 ARRSFVCHANSPGIFPVQWSLKNGLHINPPPGFRSQDFDWADYLKQCGAEAAPQKCFPQSVSEHQ 381

  Fly   907 FEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWL-DCESADIYPVGWCVLVNH 970
            |:..|.||..:.:.|..|.:|||..|.|..|.:..:|......::: ..||.:|:|:|||....|
  Rat   382 FKENMKLEAVNPLFPEEVSIATVTAVRGSYLWLQLEGSKKPVPEFIVSVESMNIFPLGWCETNGH 446

  Fly   971 KLEGP----------------------PRVAHQ----QAPKP----------APK---------- 989
            .|..|                      .|..|:    |...|          .||
  Rat   447 PLSTPRRARGHKLRKIAVVQPEKQILSSRTVHEGLKNQLNSPHSVMINGKYCCPKIYFNHRCFSG 511

  Fly   990 PKIQRKR-----------------------------KPK---------------------KGAAG 1004
            |.:.:.|                             ||.                     |....
  Rat   512 PYLNKGRIAELPQCVGPGNCVLVLREVLTLLINAAYKPSRVLRELQLDKDSVWHGCGEVLKAKYK 576

  Fly  1005 GKT---------PTDNNTQSVKSRTIALKTTPHL--PKL---------SIKLELKPEHH------ 1043
            ||:         ..|..|:..:...|.|:..|:|  |::         |:..:.|..|:
  Rat   577 GKSYRATVEIVRTADRVTEFCRQTCIKLECCPNLFGPRMVLDTCSENCSVLTKTKYTHYYGKKKN 641

  Fly  1044 -------------------------------------NAAFYEN---NQPEEEGDEEDPDADGDG 1068
                                                 ::|..:|   ..|:..|.|::.|||
  Rat   642 KRIGRPPGGHSNLSCALKKTSKRRKRRKNIFVHKKKRSSASVDNTPVGSPQGSGGEDEDDAD--- 703

  Fly  1069 DGSTSHISEQSTTQSSSDLIAGSGSGSGSASLVTLATGSNKTVKKSTTKS----PAPP---TVGR 1126
            ||....::|.||::...:|...|            .....|:...|.|:|    |.||   |..|
  Rat   704 DGDDDSLTEGSTSEQQDELHEES------------EVSEKKSCSPSPTQSEMSTPLPPDTQTDKR 756

  Fly  1127 KA-TSYIANSSATNNKYIPRLADIDSSEP-HLELVPDTWNVYDVSQFLRVNDCTAHCDTFSRNKI 1189
            :| ||.:  |...|....|:...|:..|. ||:..|..|:|.||.:|:|..||......|...:|
  Rat   757 EAQTSSL--SDGENKPPSPKEIRIEVDERLHLDSNPLKWSVADVVRFIRSTDCAPLARIFLDQEI 819

  Fly  1190 DGKRLLQLTKDDIMPLLGMKVGPALKISDLIAQLK 1224
            ||:.||.||...:...:.:|:|||:|:...|.::|
  Rat   820 DGQALLLLTLPTVQECMDLKLGPAIKLCHHIERIK 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT	542..647	CDD:214723	30/105 (29%)
		MBT	658..753	CDD:214723	34/109 (31%)
		MBT	767..871	CDD:214723	32/104 (31%)
		MBT	882..975	CDD:214723	31/93 (33%)
		TonB_N	<975..1040	CDD:292650	22/180 (12%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979	24/65 (37%)
		SAM	1160..1224	CDD:197735	23/63 (37%)
Sfmbt1	NP_113835.2	MBT 1	20..120		31/111 (28%)
		MBT	23..120	CDD:214723	30/108 (28%)
		MBT 2	128..232		36/112 (32%)
		MBT	138..232	CDD:214723	32/102 (31%)
		MBT 3	242..346		33/110 (30%)
		MBT	252..346	CDD:214723	31/100 (31%)
		MBT 4	354..451		33/96 (34%)
		MBT	358..451	CDD:214723	31/92 (34%)
		SLED	499..614	CDD:403384	15/114 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..773		29/151 (19%)
		SAM_Scm-like-4MBT1,2	779..863	CDD:188980	27/76 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343712
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3766
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740