Protein Alignment Sfmbt and SFMBT2

DIOPT Version :10

• Sequence 1: NP_001137821.1
• Gene: Sfmbt / 34709
• FlyBaseID: FBgn0032475
• Length: 1243
• Species: Drosophila melanogaster
• Sequence 2: NP_001018049.1
• Gene: SFMBT2 / 57713
• HGNCID: 20256
• Length: 894
• Species: Homo sapiens
• Alignment Length: 921
• Identity: 230/921 - (24%)
• Similarity: 339/921 - (36%)
• Gaps: 251/921 - (27%)

  Fly   519 MEKIISIRRRMYDPTHS---------------------------YDWLPRLSKENFNAAPVTCFP 556
            ||..:| ...|.||:.|                           ::|...|.:...:|||.|.|.
Human     1 MESTLS-ASNMQDPSSSPLEKCLGSANGNGDLDSEEGSSLEETGFNWGEYLEETGASAAPHTSFK 64

  Fly   557 HAPGCEVWDNLGVGMKVEVENTDCDSIEVIQPGQTPTSFWVATILEIKGYKALMSYEGFDTDSH- 620
            |.. ..:..|...|||:||.|.:           .|.::|||||:...|...|:.|.|:..|..
Human    65 HVE-ISIQSNFQPGMKLEVANKN-----------NPDTYWVATIITTCGQLLLLRYCGYGEDRRA 117

  Fly   621 DFWVNLCNAEVHSVGWCATRGKPLIPPRTIEHKYKDWKDFLVGRLSGARTLPSNFYNKINDSLQS 685
            |||.::..|::|.||||....|.|:||..|:.||.||.:||:..|:|:||.|:|.   :...|:.
Human   118 DFWCDVVIADLHPVGWCTQNNKVLMPPDAIKEKYTDWTEFLIRDLTGSRTAPANL---LEGPLRG 179

  Fly   686 R-----FRLGLNLECVDKDRISQVRLATVTKIVGKRLFLRYFDSDD----GFWCHEDSPIIHPVG 741
            :     ..:|..:|..|.....|..:.:|.:.||.||.|||...:|    ..|.......:.|||
Human   180 KGPIDLITVGSLIELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEDTESYDQWLFYLDYRLRPVG 244

  Fly   742 WATTVGHNLAAPQDYLERMLAG------REAMIEVHEDDATIELFKMNFTFDEYYSDGKTNSFVE 800
            |.....:.:..|.:.....:|.      .:::|:..:....:|:||       .::|.:::.|..
Human   245 WCQENKYRMDPPSEIYPLKMASEWKCTLEKSLIDAAKFPLPMEVFK-------DHADLRSHFFTV 302

  Fly   801 GMKLEAVDPLNLSSICPATVMAVLKFGYMMIRIDSYQPDASGSDWFCYHEKSPCIFPAGFCSVNN 865
            |||||.|:......|.||:|..|....:..:.||..:|:.|.....| |..|..|.|..:|..|.
Human   303 GMKLETVNMCEPFYISPASVTKVFNNHFFQVTIDDLRPEPSKLSMLC-HADSLGILPVQWCLKNG 366

  Fly   866 ISVTPPNGYDSRTFTWEGYLRDTGAVAAGQHLFHRIIPDHGFEVGMSLECADLMDPRLVCVATVA 930
            :|:|||.||..:.|.|..|.:..||..|....|.......||...|.||..:..:|..:|||:|.
Human   367 VSLTPPKGYSGQDFDWADYHKQHGAQEAPPFCFRNTSFSRGFTKNMKLEAVNPRNPGELCVASVV 431

  Fly   931 RVVGRLLKVHFDG-WTDEYDQWLDCESADIYPVGWCVLVNHKLEGPPRVAHQQAPKPA---PK-- 989
            .|.|||:.:|.:| .|...:..:|.||.||:|||||...::.|..|.:...|:..|.|   |:
Human   432 SVKGRLMWLHLEGLQTPVPEVIVDVESMDIFPVGWCEANSYPLTAPHKTVSQKKRKIAVVQPEKQ 496

  Fly   990 --PKIQRKRKP----------KKGAAGGK--------------TPTDNN------TQSVKS---- 1018
              |.:..|:.|          ..|...||              .|..|.      .|||..
Human   497 LPPTVPVKKIPHDLCLFPHLDTTGTVNGKYCCPQLFINHRCFSGPYLNKGRIAELPQSVGPGKCV 561

  Fly  1019 ---------------------RTIALKTTPH---------------------------------L 1029
                                 |.:.|...||                                 .
Human   562 LVLKEVLSMIINAAYKPGRVLRELQLVEDPHWNFQEETLKAKYRGKTYRAVVKIVRTSDQVANFC 626

  Fly  1030 PKLSIKLELKPEHHNAAFYENNQPE---------------------------------------- 1054
            .::..|||..|...:......|.||
Human   627 RRVCAKLECCPNLFSPVLISENCPENCSIHTKTKYTYYYGKRKKISKPPIGESNPDSGHPKPARR 691

  Fly  1055 -------------------------EEGDEEDPDADGDGDGST---SHISEQSTTQSSSDLIAGS 1091
                                     ||.:|||.||..|...|.   |.:.:..|..||:::
Human   692 RKRRKSIFVQKKRRSSAVDFTAGSGEESEEEDADAMDDDTASEETGSELRDDQTDTSSAEV---- 752

  Fly  1092 GSGSGSASLVTLATGSNKTVKKSTTKSPAPPTVGRKATSYIANSSATNNKYIP-----RLADIDS 1151
             ..:.....|||.:|| :.|::      .||...|:.....|.|||...:..|     ...|...
Human   753 -PSARPRRAVTLRSGS-EPVRR------PPPERTRRGRGAPAASSAEEGEKCPPTKPEGTEDTKQ 809

  Fly  1152 SEPH---LELVPDTWNVYDVSQFLRVNDCTAHCDTFSRNKIDGKRLLQLTKDDIMPLLGMKVGPA 1213
            .|..   ||..|..|.|.||.:|:::.||......|....|||:.||.||...:...:.:|:|||
Human   810 EEEERLVLESNPLEWTVTDVVRFIKLTDCAPLAKIFQEQDIDGQALLLLTLPTVQECMELKLGPA 874

  Fly  1214 LKISDLIAQLK 1224
            :|:...|.::|
Human   875 IKLCHQIERVK 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT_dSfmbt_rpt1	564..672	CDD:439109	42/108 (39%)
		MBT_dSfmbt_rpt2	674..753	CDD:439112	20/87 (23%)
		MBT_dSfmbt_rpt3	798..904	CDD:439115	36/105 (34%)
		MBT_dSfmbt_rpt4	905..976	CDD:439118	28/71 (39%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979	23/65 (35%)
SFMBT2	NP_001018049.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39		7/38 (18%)
		MBT 1	44..144		37/111 (33%)
		MBT_SFMBT2_rpt1	71..164	CDD:439102	39/103 (38%)
		MBT 2	152..256		29/106 (27%)
		MBT_SFMBT2_rpt2	183..281	CDD:439104	21/97 (22%)
		MBT 3	266..372		30/113 (27%)
		MBT_SFMBT2_rpt3	298..390	CDD:439106	32/92 (35%)
		MBT 4	380..477		35/96 (36%)
		MBT_SFMBT2_rpt4	407..497	CDD:439108	33/89 (37%)
		SLED	528..643	CDD:463469	13/114 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	672..813		29/152 (19%)
		SAM_Scm-like-4MBT1,2	810..894	CDD:188980	26/76 (34%)