DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sfmbt and samd11

DIOPT Version :9

Sequence 1:	NP_001137821.1	Gene:	Sfmbt / 34709	FlyBaseID:	FBgn0032475	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	XP_009295182.1	Gene:	samd11 / 569122	ZFINID:	ZDB-GENE-060428-2	Length:	874	Species:	Danio rerio

Alignment Length:	939	Identity:	174/939 - (18%)
Similarity:	291/939 - (30%)	Gaps:	300/939 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   432 GEPMSMGGDAAANNVQMAADETIAALNGGAVGDAT--APGSTEEGASTPNSYLSAAPT---PKAL 491
            ||.|::   ||.|.     .|.:|.||..|:...|  .|......|....:||....|   .:.|
Zfish    11 GEDMAL---AAFNQ-----PEYLAPLNATAIPVVTPHPPPYDHIFAHHQRAYLGFRDTALHQQHL 67

  Fly   492 RLFKDIYPQDDLPQIPKYER--------LPVPCPQMEKIISIRRRMY---DPTHSY--DWL-PR- 541
            ....|.:..:....||.::.        :.|.|.:.:.::.|.:...   .|:..|  :|| |.
Zfish    68 HHHPDDFMLESFSSIPDFQPFFDNGEPCIEVECGENKALLYINKLCQGSKGPSIKYRTEWLTPNE 132

  Fly   542 ---------------------------LSKENFNAAPVTCFPHAPGCEVWDNLGVGMKVEVENTD 579
                                       :||......|..|  ..|||.:...:..|...|.....
Zfish   133 FQFVSGRETAKDWKRSIRHKGKSLKTLMSKGILQVHPPIC--DCPGCRISSPVNRGRLAEKRTIP 195

  Fly   580 CDSIEVIQPGQTPTSFWVATILEIKGYKALMSYEGFDTDSHDFWVNLCNAEVHSVGWCATRGKPL 644
                  :.|.:.|..       |:....:....||.:..|.|. .::...|::.
Zfish   196 ------LPPTRVPKK-------ELASVFSSDDSEGSERASGDH-ADIKQEELNF----------- 235

  Fly   645 IPPRTIEHKYKDWKDFLVGRLSGARTLPSNFYNKINDSLQSRFRLGLNLECVDKDRISQVRLATV 709
                ||..|.:|         |...|:.||.::.....:..      ...|.|....|    |..
Zfish   236 ----TIMRKSRD---------SDLSTIISNLHHTRQHGMPE------GQSCSDLSLAS----AHT 277

  Fly   710 TKIVGKRLFLRYFDSDDGFWCHEDS--------------PIIHPVGWATTVGHNLAAPQDYLERM 760
            ..|:|||   |.:..:....|..||              |.:.|....|        |:::..||
Zfish   278 DDILGKR---RAYSPNSSSECPSDSKKSRSVSPKENSHTPALEPGSHMT--------PEEHYRRM 331

  Fly   761 LAGREAMIEVHEDDATIELFKMNFTFDEYYSDGKTNSFVEGMKLEAVDPLNLSSICPATVMAVLK 825
            ::.........|....:.....|.....:                     .|..:....::||..
Zfish   332 MSALNEHGSYEEQQQRLYQLANNMGIPSH---------------------ELLHVRQEAMVAVRN 375

  Fly   826 FGYMMIRIDSYQPDASGSDWFCYHEKSP----CIFPAGFCSVNNISVTPPNGYDSRTFTWEGYLR 886
            .|.|    :::.|.|..|......:..|    ..||.     .:||..||            .|.
Zfish   376 PGGM----EAHVPSAGSSSSQRRKQGLPQHRDAHFPE-----RDISHPPP------------LLS 419

  Fly   887 DTGA--VAAGQHLFHRII---------PDHGF----EVGMSLECADLMD----PRLVCVATVARV 932
            ...|  :|.|.||....:         |.:||    :..|.....:::.    .||...|.:.|
Zfish   420 PQNAPHIALGPHLRPPFLGMPSALCQAPGYGFLQPAQAEMFARQQEILRKQNLARLEMSAELLR- 483

  Fly   933 VGRLLKVHFDGWTDEYDQWLDCESADIYPVGWCVLVNHKLEGPPRVAHQQAPKPAP-KPKIQRKR 996
            ...|..:|        .|.|..:...::|       ....|.|...:.|:.|:..| :.::.|:.
Zfish   484 QKELENLH--------RQRLLADPLGLHP-------GLPAEHPALRSLQEIPEGHPLREELNRRN 533

  Fly   997 K--------------PKKGAAGGKTPTD-NNTQSVK-------SRTIALKTTPHLPKLSIKLELK 1039
            .              ..:|||.|.:..| :|.:|::       .:......|..:.:.....:::
Zfish   534 AMLVLRHNNTPLLSLNHQGAAAGTSSKDLSNRKSLRKGGPLQGDQQGGSSETKEMLREGCVRDVE 598

  Fly  1040 PEHHNAAFYENNQPEEEGDEEDPD--ADGDGDGSTSHISEQSTTQSSSDLIAGSGSGSGSASLVT 1102
            .|..:....::....|.| |:.|:  :.|||.|.:|.:.:......:|:.|...|.|||..|:..
Zfish   599 TEGMDEDMKDSENDAEVG-EDRPERLSKGDGHGLSSEVCQGKDVTKTSEAIKELGEGSGRLSVPC 662

  Fly  1103 LATGSNKTVKKSTTKSPAPPTVGRKATSYIANSSATNN--KYIPRLADIDSSEPHLELVP----- 1160
            .:||.         :||         |.::..|....|  ||:|      ...|.|..:|
Zfish   663 SSTGQ---------ESP---------THHLFTSGLGKNEAKYLP------PGIPPLPTLPGQMLP 703

  Fly  1161 -------------------------------DTWNVYDVSQFL-RVNDCTAHCDTFSRNKIDGKR 1193
                                           ..|:|.:|..|: .:..|..:...|....|||:.
Zfish   704 FTFPYSSPYFHTGAMGGLFVDGEEAGAAEDISKWSVEEVCSFISSLAGCGEYTQVFREQAIDGET 768

  Fly  1194 LLQLTKDDIMPLLGMKVGPALKISDLIAQ 1222
            |..||:|.::..:|:|:||||||...:|:
Zfish   769 LPLLTEDHLLNNMGLKLGPALKIRSQVAR 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT	542..647	CDD:214723	17/104 (16%)
		MBT	658..753	CDD:214723	19/108 (18%)
		MBT	767..871	CDD:214723	15/107 (14%)
		MBT	882..975	CDD:214723	20/111 (18%)
		TonB_N	<975..1040	CDD:292650	13/87 (15%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979	23/100 (23%)
		SAM	1160..1224	CDD:197735	23/100 (23%)
samd11	XP_009295182.1	SAND	93..165	CDD:279658	10/71 (14%)
		SAM_Samd7,11	734..801	CDD:188978	22/64 (34%)
		SAM	735..791	CDD:197735	19/55 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583963
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840