DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sfmbt and mbtd1

DIOPT Version :9

Sequence 1:	NP_001137821.1	Gene:	Sfmbt / 34709	FlyBaseID:	FBgn0032475	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	XP_005169539.2	Gene:	mbtd1 / 568340	ZFINID:	ZDB-GENE-060810-138	Length:	705	Species:	Danio rerio

Alignment Length:	854	Identity:	295/854 - (34%)
Similarity:	420/854 - (49%)	Gaps:	175/854 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 ENT--SSKQMQRTYSTAKGANSTATTATCSASTSSALRSQRKTRKIEPVNRPGLVLKTPIAYRGN 315
            |:|  |.::.:.::....|.:|      ||..:||:..|:....::     |.:....|| .:.|
Zfish     9 EHTPRSERKRRDSFGMFDGYDS------CSEDSSSSSSSEDTEDEV-----PSIPASLPI-IKNN 61

  Fly   316 IDPSVIPIQKDGMAVCKRCGAIGVKHTFYTKSRRFCSMACARGELYSLVLNTKMEGDQATTSSPD 380
            ......|..|.|||.|:.||.:||:..||:|::||||::|:|.
Zfish    62 GQVYTYPDGKAGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRS---------------------- 104

  Fly   381 PGAGSESADLPGDQQQSQSDIELDLHAAHIKNANYRFRITDQSKITQLNSFGEPMSMGGDAAANN 445
                                     ::::.|.|:...|:.           |:|
Zfish   105 -------------------------YSSNSKKASILARLQ-----------GKP----------- 122

  Fly   446 VQMAADETIAALNGGAVGDATAPGSTEEGASTPNSYLSAAPTPKALRLFKDIYPQDDLPQIPKYE 510
                                                    ||.||    |.:..|..:.::..|.
Zfish   123 ----------------------------------------PTKKA----KVLQKQPLMAKLAAYA 143

  Fly   511 RLPVPCPQMEKIISIRRRMYDPTHSYDWLPRLSKENFNAAPVTCFPHAPGCEVWDNLGVGMKVEV 575
            :.........|..|:     .|...:||...:...|...|||:||.|.|....|.::..|::|||
Zfish   144 QYQASQQNQAKSKSV-----VPVEGFDWGQYICSNNLVGAPVSCFKHVPMGMCWGDIAEGLRVEV 203

  Fly   576 ENTDCD-SIEVIQPGQTPTSFWVATILEIKGYKALMSYEGFDTD-SHDFWVNLCNAEVHSVGWCA 638
            .|:|.: |.:|         :|||.|:::.|:|||:.|||||.| |.|||.|||..|:|.|||||
Zfish   204 FNSDTNLSTKV---------YWVAEIVKLAGFKALLRYEGFDNDSSRDFWCNLCIPEIHPVGWCA 259

  Fly   639 TRGKPLIPPRTIEHKYKDWKDFLVGRLSGARTLPSNFYNKINDSLQSRFRLGLNLECVDKDRISQ 703
            :.||||:||::|:|||.:||.|||.||:||:|||..|..|:.:::|..|:..:.:|.|||..:.:
Zfish   260 SSGKPLVPPKSIQHKYSNWKAFLVKRLTGAKTLPPEFATKVQENMQYPFKKLMRVEVVDKTHLCR 324

  Fly   704 VRLATVTKIVGKRLFLRYFDSDDG---FWCHEDSPIIHPVGWATTVGHNLAAPQDYLERMLAGRE 765
            .|:|.|.:::|.||.|.|.:|.||   ||||..||:||.:||:.::||.....:  :.:.:.|
Zfish   325 TRVALVEQVIGGRLRLVYEESQDGTDDFWCHMLSPLIHSIGWSRSIGHRFKRSE--VSKKIEG-- 385

  Fly   766 AMIEVHEDDATIELFKMNFTFDEYYSDGKTNSFVEGMKLEAVDPLNLSSICPATVMAVLKFGYMM 830
                  :.||..:||......|:     ..:.|.:||||||:||||||:||.|||..||..||:|
Zfish   386 ------QMDAPSQLFLKIKDVDQ-----NGDWFKDGMKLEAIDPLNLSAICVATVRKVLADGYLM 439

  Fly   831 IRIDSYQPDASGSDWFCYHEKSPCIFPAGFCSVNNISVTPPNGYDSRTFTWEGYLRDTGAVAAGQ 895
            |.||..:. |.||||||||..||.|||.|||.:|:|.:|||.|.....|.|..|||:.|::||..
Zfish   440 IGIDGSEA-ADGSDWFCYHSTSPSIFPVGFCEINSIELTPPRGCTKLPFKWFDYLREIGSIAAPV 503

  Fly   896 HLFHRIIPDHGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWLDCESADIY 960
            .||::.:|:|||.|||.||..|||:|||||||||.|:|.|||::|||||.||||||:||||.|:|
Zfish   504 KLFNKDVPNHGFRVGMKLEAVDLMEPRLVCVATVTRIVHRLLRIHFDGWEDEYDQWVDCESPDLY 568

  Fly   961 PVGWCVLVNHKLEGPPRVAHQQAPKPAPKPKIQRKRKPKKGAAGGKTPTDNNTQSVKSRTIALKT 1025
            |:|||.|..::|:.|.....::||     |.:.   |.||.||..|.........|..|.|.|..
Zfish   569 PIGWCQLTGYQLQPPAAQTTREAP-----PNVS---KQKKKAAQYKGQKKKRKIPVGRRPIGLGG 625

  Fly  1026 TPHLPKLSIKLELKPEHHNAAFYENNQPEEEGDEEDPDADGDGD----GSTSHISEQSTTQSSSD 1086
            .......|...|..|.|:.:.|..:.:|...|.|.|...:.:..    ..|..|.|.:.:|..||
Zfish   626 PLRRRSFSGDEEQTPPHYLSHFSGSRRPPASGVERDRSLNSEASLQVKEETPEIDEFTFSQGISD 690

  Fly  1087 LIAGSGSGS 1095
            . ..:||||
Zfish   691 Q-ESNGSGS 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT	542..647	CDD:214723	49/106 (46%)
		MBT	658..753	CDD:214723	42/97 (43%)
		MBT	767..871	CDD:214723	51/103 (50%)
		MBT	882..975	CDD:214723	57/92 (62%)
		TonB_N	<975..1040	CDD:292650	16/64 (25%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979
		SAM	1160..1224	CDD:197735
mbtd1	XP_005169539.2	MBT	169..268	CDD:214723	49/107 (46%)
		MBT	285..375	CDD:214723	38/89 (43%)
		MBT	384..479	CDD:214723	52/108 (48%)
		MBT	491..583	CDD:214723	57/91 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6286
eggNOG	1	0.900	-	-		E1_KOG3766
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41185
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1245
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002222
OrthoInspector	1	1.000	-	-		otm25420
orthoMCL	1	0.900	-	-		OOG6_105853
Panther	1	1.100	-	-	O	PTHR12247
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2614
SonicParanoid	1	1.000	-	-		X1465
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.940