Protein Alignment Sfmbt and MBTD1

DIOPT Version :10

• Sequence 1: NP_001137821.1
• Gene: Sfmbt / 34709
• FlyBaseID: FBgn0032475
• Length: 1243
• Species: Drosophila melanogaster
• Sequence 2: XP_011523224.1
• Gene: MBTD1 / 54799
• HGNCID: 19866
• Length: 717
• Species: Homo sapiens
• Alignment Length: 876
• Identity: 296/876 - (33%)
• Similarity: 419/876 - (47%)
• Gaps: 217/876 - (24%)

  Fly   252 TENTSSKQMQR--TYSTAKGANSTATTATCSASTSSALRSQRKTRKIEPVNRPGLVLKTPIAYRG 314
            ||::|..:.:|  ::....|.:|      ||..|||:..|:....::.|     |....|| .:.
Human     8 TEHSSRSERKRRDSFGMFDGYDS------CSEDTSSSSSSEESEEEVAP-----LPSNLPI-IKN 60

  Fly   315 NIDPSVIPIQKDGMAVCKRCGAIGVKHTFYTKSRRFCSMACARGELYSLVLNTKMEGDQATTSSP 379
            |......|..|.|||.|:.||.:||:..||:|::||||::|:|.  ||
Human    61 NGQVYTYPDGKSGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRS--YS----------------- 106

  Fly   380 DPGAGSESADLPGDQQQSQSDIELDLHAAHIKNANYRFRITDQSKITQLNSFGEPMSMGGDAAAN 444
               :.|:.|.:                                  :.:|...|:|
Human   107 ---SNSKKASI----------------------------------LARLQVTGKP---------- 124

  Fly   445 NVQMAADETIAALNGGAVGDATAPGSTEEGASTPNSYLSAAPTPKALRLFKDIYPQDDLPQIPKY 509
                                                     ||.||    |.:..|..:.::..|
Human   125 -----------------------------------------PTKKA----KVLQKQPLVAKLAAY 144

  Fly   510 ERLPVPCPQMEK---IISIRRRMYDPTHSYDWLPRLSKENFNAAPVTCFPHAPGCEVWDNLGVGM 571
            .:.........|   .:|:        ..:.|...::..:|.|||||||.|||....|.::...:
Human   145 AQYQATLQNQAKTKAAVSM--------EGFSWGNYINSNSFIAAPVTCFKHAPMGTCWGDISENV 201

  Fly   572 KVEVENTDCDSIEVIQPGQTPTS-FWVATILEIKGYKALMSYEGFDTDSH-DFWVNLCNAEVHSV 634
            :|||.||||         ..||. ||:|.|:::.||.||:.||||:.||. |||.|:|.:::|.|
Human   202 RVEVPNTDC---------SLPTKVFWIAGIVKLAGYNALLRYEGFENDSGLDFWCNICGSDIHPV 257

  Fly   635 GWCATRGKPLIPPRTIEHKYKDWKDFLVGRLSGARTLPSNFYNKINDSLQSRFRLGLNLECVDKD 699
            ||||..||||:|||||:|||.:||.|||.||:||:|||.:|..|:::|:|..|:..:.:|.|||.
Human   258 GWCAASGKPLVPPRTIQHKYTNWKAFLVKRLTGAKTLPPDFSQKVSESMQYPFKPCMRVEVVDKR 322

  Fly   700 RISQVRLATVTKIVGKRLFLRYFDSD---DGFWCHEDSPIIHPVGWATTVGH-----NLAAPQDY 756
            .:.:.|:|.|..::|.||.|.|.:|:   |.||||..||:||.:||:.::||     ::...||
Human   323 HLCRTRVAVVESVIGGRLRLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGHRFKRSDITKKQD- 386

  Fly   757 LERMLAGR-----EAMIEVHEDDATIELFKMNFTFDEYYSDGKTNSFVEGMKLEAVDPLNLSSIC 816
                  |.     ....:|.|.|.:.|.||                  |||||||:||||||:||
Human   387 ------GHFDTPPHLFAKVKEVDQSGEWFK------------------EGMKLEAIDPLNLSTIC 427

  Fly   817 PATVMAVLKFGYMMIRIDSYQPDASGSDWFCYHEKSPCIFPAGFCSVNNISVTPPNGYDSRTFTW 881
            .||:..||..|::||.||..:. |.||||||||..||.|||.|||.:|.|.:|||.||....|.|
Human   428 VATIRKVLADGFLMIGIDGSEA-ADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKLPFKW 491

  Fly   882 EGYLRDTGAVAAGQHLFHRIIPDHGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTD 946
            ..|||:||::||...||::.:|:|||.|||.||..|||:|||:|||||.|::.|||::|||||.:
Human   492 FDYLRETGSIAAPVKLFNKDVPNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEE 556

  Fly   947 EYDQWLDCESADIYPVGWCVLVNHKLEGPPRVAHQQAPKPAPKPKIQRK------RKPKKGAAGG 1005
            |||||:||||.|:||||||.|..::|:.|...:.::....:.|.|.:.|      .|.|:....|
Human   557 EYDQWVDCESPDLYPVGWCQLTGYQLQPPASQSSRENQSASSKQKKKAKSQQYKGHKKKRKMPIG 621

  Fly  1006 KTPT-----------------DNNTQSVKSRTIALKTTPH-LPKLSIKLELKPEHHNAAFYENNQ 1052
            |.|.                 |........||:..:|.|. .|..|...|..|........:  .
Human   622 KKPVSLSSLPMTGGVRRSFSGDEELTPPPYRTLPAQTAPEAFPPPSTSREFSPSLKTVTTLQ--L 684

  Fly  1053 PEEEGDEEDPD-----ADGDGDGSTSHISEQ 1078
            .||..|.||.:     :|.:.:||.:...:|
Human   685 KEELLDGEDYNFLQGASDQESNGSANFYIKQ 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT_dSfmbt_rpt1	564..672	CDD:439109	57/109 (52%)
		MBT_dSfmbt_rpt2	674..753	CDD:439112	31/86 (36%)
		MBT_dSfmbt_rpt3	798..904	CDD:439115	59/105 (56%)
		MBT_dSfmbt_rpt4	905..976	CDD:439118	46/70 (66%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979
MBTD1	XP_011523224.1	MBT_MBTD1_rpt1	194..296	CDD:439110	58/110 (53%)
		MBT_MBTD1_rpt2	297..381	CDD:439113	31/83 (37%)
		MBT_MBTD1_rpt3	409..499	CDD:439116	55/108 (51%)
		MBT_MBTD1_rpt4	515..585	CDD:439119	46/69 (67%)