DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sfmbt and Phc2

DIOPT Version :9

Sequence 1:	NP_001137821.1	Gene:	Sfmbt / 34709	FlyBaseID:	FBgn0032475	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001182059.1	Gene:	Phc2 / 54383	MGIID:	1860454	Length:	850	Species:	Mus musculus

Alignment Length:	318	Identity:	73/318 - (22%)
Similarity:	125/318 - (39%)	Gaps:	89/318 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   967 LVNHKLEGPPRVAHQQAPKPAPKPKI-----QRKRKPKKGAAGGKTPTDNNTQSVKSRTIALKTT 1026
            ::.|.:||   ...|:..:|.|..:.     ..|:|..:|....|.|..::|.:..|.    ...
Mouse   560 ILTHVIEG---FVIQEGAEPFPVGRSSLLVGNLKKKYAQGFLPEKPPQQDHTTTTDSE----MEE 617

  Fly  1027 PHLPK-------LSIKLEL--------------------KPEHHNAA-------FYENNQPEEEG 1057
            |:|.:       |.:|.||                    ..:.:|..       |:.:....::.
Mouse   618 PYLQESKEEGTPLKLKCELCGRVDFAYKFKRSKRFCSMACAKRYNVGCTKRVGLFHSDRSKLQKA 682

  Fly  1058 DEEDPDADGDGDGSTSHISEQSTTQSSSDLIAGS-GSGSGSASL-VTLA-------TGSNKTVKK 1113
                        |:|:|...:::..|...|...: ...||:..| ||.|       ..|::....
Mouse   683 ------------GTTTHNRRRASKASLPTLTKDTKKQPSGTVPLSVTAALQLAHSQEDSSRCSDN 735

  Fly  1114 STTKSPAPPTVGRKATSYIANSSATNNKYIPRLADIDSSEPHL-ELV----------PDTWNVYD 1167
            |:.:.|..|         |:.||:|:.:...: .|:|..:.|: :||          |..|||.|
Mouse   736 SSYEEPLSP---------ISASSSTSRRRQGQ-RDLDLPDMHMRDLVGVGHHFLPSEPTKWNVED 790

  Fly  1168 VSQFLR-VNDCTAHCDTFSRNKIDGKRLLQLTKDDIMPLLGMKVGPALKISDLIAQLK 1224
            |.:|:| :..|....:.|...:|||:.||.|.:|.:|..:.:|:||||||...|:.||
Mouse   791 VYEFIRSLPGCQEIAEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKIYARISMLK 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT	542..647	CDD:214723
		MBT	658..753	CDD:214723
		MBT	767..871	CDD:214723
		MBT	882..975	CDD:214723	2/7 (29%)
		TonB_N	<975..1040	CDD:292650	16/96 (17%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979	28/66 (42%)
		SAM	1160..1224	CDD:197735	26/64 (41%)
Phc2	NP_001182059.1	Disordered. /evidence=ECO:0000269\|PubMed:27827373	1..79
		Interaction with BMI1. /evidence=ECO:0000269\|PubMed:27827373	33..56
		PHA03247	<216..540	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..314
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..386
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	402..436
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..553
		HD1	550..579		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..624		6/30 (20%)
		PHC2_SAM_assoc	662..780	CDD:374673	26/139 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..712		7/47 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	725..764		10/48 (21%)
		SAM_Ph1,2,3	781..849	CDD:188976	28/68 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839868
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840