DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sfmbt and SFMBT1

DIOPT Version :9

Sequence 1:	NP_001137821.1	Gene:	Sfmbt / 34709	FlyBaseID:	FBgn0032475	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_057413.2	Gene:	SFMBT1 / 51460	HGNCID:	20255	Length:	866	Species:	Homo sapiens

Alignment Length:	875	Identity:	223/875 - (25%)
Similarity:	333/875 - (38%)	Gaps:	227/875 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   538 WLPRLSKENFNAAPVTCFPHAPGCEVWDNLGVGMKVEVE-NTDCDSIEVIQPGQTPTSFWVATIL 601
            |...|.:....|.|...|.|. ...:.:....|||:||. .||            |.::||||::
Human    22 WEDYLEETGSTAVPYGSFKHV-DTRLQNGFAPGMKLEVAVRTD------------PETYWVATVI 73

  Fly   602 EIKGYKALMSYEGFDTDSH-DFWVNLCNAEVHSVGWCATRGKPLIPPRTIEHKYKDWKDFLVGRL 665
            .......|:.|:|:..|.. |||.::..|:::.:|||....|.|..|..|..|..||.:||...|
Human    74 TTCEQLLLLRYDGYGEDRRADFWCDIRKADLYPIGWCEQNKKTLEAPEGIRDKVSDWDEFLRQTL 138

  Fly   666 SGARTLPSNFYNKINDSLQ--SRFRLGLNLEC-VDKDRISQVRLATVTKIVGKRLFLRY--FDSD 725
            .||.:.|......:.:...  .....|..||| ..:|.:| ..:.||.:.:|.||.|||  .:|.
Human   139 IGACSPPVPLLEGLRNGRNPLDLIAPGSRLECQAFQDSLS-TWIVTVVENIGGRLKLRYEGLESS 202

  Fly   726 DGF--WCHEDSPIIHPVGWATTVGHNLAAPQ--DYLERMLAGREAMIEVHEDDATIELFKMNFTF 786
            |.:  |.:...|.:|.||||...|:.|..|.  .:|:.....:|.:.:|.|::   |....::.|
Human   203 DNYEHWLYYLDPFLHHVGWAAQQGYELQPPSAIRHLKNEAEWQEILAKVKEEE---EEPLPSYLF 264

  Fly   787 DEYYSDGKTNSFVEGMKLEAVDPLNLSSICPATVMAVLKFGYMMIRIDSYQPDASGSDWFCYHEK 851
            .:....| .::|...||||||||.:...|.||||:.|....|.::.:|..:|:......|..|..
Human   265 KDKQVIG-IHTFSVNMKLEAVDPWSPFGISPATVVKVFDEKYFLVEMDDLRPENHARRSFVCHAD 328

  Fly   852 SPCIFPAGFCSVNNISVTPPNGYDSRTFTWEGYLRDTGAVAAGQHLFHRIIPDHGFEVGMSLECA 916
            ||.|||..:...|.:.::||.||.|:.|.|..||:..||.||.|..|..:|.:|.|:..|.||..
Human   329 SPGIFPVQWSLKNGLHISPPPGYPSQDFDWADYLKQCGAEAAPQRCFPPLISEHEFKENMKLEAV 393

  Fly   917 DLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWL-DCESADIYPVGWCVLVNHKLEGPPR--- 977
            :.:.|..|||||:..|.|..|.:..:|......:.: ..||.||:|:|||....|.|..|.|
Human   394 NPILPEEVCVATITAVRGSYLWLQLEGSKKPIPECIVSVESMDIFPLGWCETNGHPLSTPRRARV 458

  Fly   978 -----VAHQQAPKPAPK---------------------------PK------------------- 991
                 :|..|..|..|.                           ||
Human   459 YKQRKIAVVQPEKQVPSSRTVHEGLRNQELNSTESVMINGKYCCPKIYFNHRCFSGPYLNKGRIA 523

  Fly   992 ----------------------IQRKRKPK---------------------KGAAGGKT------ 1007
                                  |....||.                     |....||:
Human   524 ELPQCVGPGNCVLVLREVLTLLINAAYKPSRVLRELQLDKDSVWHGCGEVLKAKYKGKSYRATVE 588

  Fly  1008 ---PTDNNTQSVKSRTIALKTTPHL--PKL---------SIKLELKPEHH--------------- 1043
               ..|..|:..:...|.|:..|:|  |::         |:..:.|..|:
Human   589 IVKTADRVTEFCRQTCIKLECCPNLFGPRMVLDKCSENCSVLTKTKYTHYYGKKKNKRIGRPPGG 653

  Fly  1044 ----------------------------NAAFYEN---NQPEEEG--DEEDPDADGDGDGSTSHI 1075
                                        ::|..:|   ..|:..|  ||:||| :||.|.    :
Human   654 HSNLACALKKASKRRKRRKNVFVHKKKRSSASVDNTPAGSPQGSGGEDEDDPD-EGDDDS----L 713

  Fly  1076 SEQSTTQSSSDLIAGSGSGSGSASLVTLATGSNKTVKKSTTKSPA--------PPTVGRKATSY- 1131
            ||.||::...:                |...|..:.|||.:.||.        ||...|:....
Human   714 SEGSTSEQQDE----------------LQEESEMSEKKSCSSSPTQSEISTSLPPDRQRRKRELR 762

  Fly  1132 -IANSSATNNKYIPRLADIDSSEP-HLELVPDTWNVYDVSQFLRVNDCTAHCDTFSRNKIDGKRL 1194
             .:.|...|....|:...|:.:|. ||:..|..|:|.||.:|:|..||......|...:|||:.|
Human   763 TFSFSDDENKPPSPKEIRIEVAERLHLDSNPLKWSVADVVRFIRSTDCAPLARIFLDQEIDGQAL 827

  Fly  1195 LQLTKDDIMPLLGMKVGPALKISDLIAQLK 1224
            |.||...:...:.:|:|||:|:...|.::|
Human   828 LLLTLPTVQECMDLKLGPAIKLCHHIERIK 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT	542..647	CDD:214723	30/106 (28%)
		MBT	658..753	CDD:214723	31/101 (31%)
		MBT	767..871	CDD:214723	31/103 (30%)
		MBT	882..975	CDD:214723	34/93 (37%)
		TonB_N	<975..1040	CDD:292650	22/181 (12%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979	24/65 (37%)
		SAM	1160..1224	CDD:197735	23/63 (37%)
SFMBT1	NP_057413.2	MBT 1	20..120		31/110 (28%)
		MBT	23..120	CDD:214723	30/109 (28%)
		Antigenic epitope	34..42		2/7 (29%)
		MBT 2	128..232		33/104 (32%)
		MBT	131..232	CDD:214723	31/101 (31%)
		MBT 3	242..348		32/109 (29%)
		MBT	252..348	CDD:214723	30/99 (30%)
		MBT 4	356..453		36/96 (38%)
		MBT	360..453	CDD:214723	34/92 (37%)
		DUF3588	502..617	CDD:288954	14/114 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	641..777		28/156 (18%)
		SAM_Scm-like-4MBT1,2	782..866	CDD:188980	27/76 (36%)
		SAM	793..857	CDD:197735	23/63 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149823
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3766
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740