DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sfmbt and mbtd1

DIOPT Version :9

Sequence 1:	NP_001137821.1	Gene:	Sfmbt / 34709	FlyBaseID:	FBgn0032475	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001006742.1	Gene:	mbtd1 / 448411	XenbaseID:	XB-GENE-949653	Length:	651	Species:	Xenopus tropicalis

Alignment Length:	762	Identity:	275/762 - (36%)
Similarity:	388/762 - (50%)	Gaps:	168/762 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 MVSTENTSSKQMQRTYSTAKGANSTATTATCSASTSSALRSQRKTRKIEPVNRPGLVLKTPIAYR 313
            :....:.|.::.:.::....|.:|      ||..|||:..|.....::.|     |....|| .:
Frog     7 LADLSSLSERKRRDSFGMFDGYDS------CSEDTSSSSSSDESEEEVAP-----LPSSLPI-IK 59

  Fly   314 GNIDPSVIPIQKDGMAVCKRCGAIGVKHTFYTKSRRFCSMACARGELYSLVLNTKMEGDQATTSS 378
            .|......|..|.|||.|:.||.:||:..||:|::||||::|:|.  ||  .|:|.....|....
Frog    60 NNGQVYTYPDGKSGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRS--YS--SNSKKASILARLQG 120

  Fly   379 PDPGAGSESADLPGDQQQSQSDIELDLHAAHIKNANYRFRITDQSKITQLNSFGEPMSMGGDAAA 443
            ..|                                      |.::|:.|    .:|:
Frog   121 KPP--------------------------------------TKKAKVLQ----KKPL-------- 135

  Fly   444 NNVQMAADETIAALNGGAVGDATAPGSTEEGASTPNSYLSAAPTPKALRLFKDIYPQDDLPQIPK 508
                      :|.|...|          :..|:..|..::.||.
Frog   136 ----------VAKLAAYA----------QYKATLKNQSVNKAPV--------------------- 159

  Fly   509 YERLPVPCPQMEKIISIRRRMYDPTHSYDWLPRLSKENFNAAPVTCFPHAPGCEVWDNLGVGMKV 573
                                   ....:.|...::..|..|||||||.|||....|.::..|::|
Frog   160 -----------------------TVEGFSWGNYITSNNTAAAPVTCFRHAPMGNCWGDIAEGVRV 201

  Fly   574 EVENTDCDSIEVIQPGQTPTS-FWVATILEIKGYKALMSYEGFDTDSH-DFWVNLCNAEVHSVGW 636
            ||.|||         ...||. ||::.|:::.|:.||:.||||:.||. |||.|:|..:||.|||
Frog   202 EVPNTD---------SNLPTKVFWISGIVKLAGFNALLRYEGFENDSSLDFWCNICGPDVHPVGW 257

  Fly   637 CATRGKPLIPPRTIEHKYKDWKDFLVGRLSGARTLPSNFYNKINDSLQSRFRLGLNLECVDKDRI 701
            |||.||||:||:||:|||.:||.|||.||:||:|||.:|..|:::|:|..|:..:.:|.|||..:
Frog   258 CATSGKPLVPPQTIQHKYTNWKAFLVKRLTGAKTLPPDFSQKVSESMQYPFKPSMRVEVVDKTHL 322

  Fly   702 SQVRLATVTKIVGKRLFLRYFDSD---DGFWCHEDSPIIHPVGWATTVGHNLAAPQDYLERMLAG 763
            .:.|:|.|..::|.||.|.|.:|:   |.||||..||:|||:||:.::||.... .|.|::..:.
Frog   323 CRTRVAVVDSVIGGRLRLVYEESEDKTDDFWCHMYSPLIHPIGWSRSIGHRFKR-TDILKKQESN 386

  Fly   764 REA----MIEVHEDDATIELFKMNFTFDEYYSDGKTNSFVEGMKLEAVDPLNLSSICPATVMAVL 824
            .:|    ..:|.:.:...|.||                  |||||||:||||||:||.||:..||
Frog   387 YDAPSHLFTKVKDIEQGSEWFK------------------EGMKLEAIDPLNLSAICVATIRKVL 433

  Fly   825 KFGYMMIRIDSYQPDASGSDWFCYHEKSPCIFPAGFCSVNNISVTPPNGYDSRTFTWEGYLRDTG 889
            ..||:||.||..:. |.||||||||..||.|||.|||.:|.|.:|||.||....|.|..|||:||
Frog   434 ADGYLMIGIDGSEA-ADGSDWFCYHASSPSIFPVGFCEINKIELTPPRGYTKLPFKWFDYLRETG 497

  Fly   890 AVAAGQHLFHRIIPDHGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWLDC 954
            ::||...||::.:|:|||.|||.||..|||:|||||||||.|::.|||::|||||.||||||:||
Frog   498 SIAAPVKLFNKEVPNHGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDC 562

  Fly   955 ESADIYPVGWCVLVNHKLEGPPRVAHQQAPKPAPKPKIQRKRKPKKG 1001
            ||:|:||||||.|..::|:.|...:::.:.....|.|.:.|.:|.||
Frog   563 ESSDLYPVGWCQLTGYQLQPPAPQSNKDSQSNISKQKKKSKSQPYKG 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT	542..647	CDD:214723	50/106 (47%)
		MBT	658..753	CDD:214723	43/97 (44%)
		MBT	767..871	CDD:214723	49/103 (48%)
		MBT	882..975	CDD:214723	58/92 (63%)
		TonB_N	<975..1040	CDD:292650	7/27 (26%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979
		SAM	1160..1224	CDD:197735
mbtd1	NP_001006742.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..55		10/44 (23%)
		MBT 1	164..268		51/112 (46%)
		MBT	168..268	CDD:214723	50/108 (46%)
		MBT 2	276..373		43/96 (45%)
		MBT	285..375	CDD:214723	39/89 (44%)
		MBT 3	374..479		52/124 (42%)
		MBT	378..479	CDD:214723	52/119 (44%)
		MBT 4	487..583		60/95 (63%)
		MBT	491..583	CDD:214723	58/91 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..610		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..651
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	110	1.000	Domainoid score	I6229
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41185
Inparanoid	1	1.050	520	1.000	Inparanoid score	I1241
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002222
OrthoInspector	1	1.000	-	-		otm48125
Panther	1	1.100	-	-	O	PTHR12247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2614
SonicParanoid	1	1.000	-	-		X1465
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.090