DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sfmbt and SAMD7

DIOPT Version :9

Sequence 1:	NP_001137821.1	Gene:	Sfmbt / 34709	FlyBaseID:	FBgn0032475	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001291295.1	Gene:	SAMD7 / 344658	HGNCID:	25394	Length:	446	Species:	Homo sapiens

Alignment Length:	276	Identity:	63/276 - (22%)
Similarity:	104/276 - (37%)	Gaps:	73/276 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   972 LEGPPRVAHQQAPKPAPKPKI-----QRKRKPKKGAAGGKTPTDNNTQSVKSRTIALKTTPHLPK 1031
            |:|.|.:|       |..|..     ||.|:.:|. .|.:...|::.:|.||:.
Human   160 LQGNPMLA-------ATAPHFEESWGQRCRRLRKN-TGNQKALDSDAESSKSQA----------- 205

  Fly  1032 LSIKLELKPEHHNAAFYENNQPEEEGDEEDPDADGDGDGSTSHISEQSTT--------------- 1081
               :.::..:.|...:      ||:...:|||.:...:..:|..:|:.||
Human   206 ---EEKILGQTHAVPY------EEDHYAKDPDIEAPSNQKSSETNEKPTTALANTCGELEPTHRK 261

  Fly  1082 ---QSSSDLIAGS-GSGSGSASLVTLATGSNKTVKKSTTKSPAPPTVGRKATSYIANSSATNNKY 1142
               ..::.|.|.: ..|...||....||...|  .......|.|...|..|...|..:.:.:.
Human   262 PWGSHTTTLKAKAWDDGKEEASEQIFATCDEK--NGVCPPVPRPSLPGTHALVTIGGNLSLDE-- 322

  Fly  1143 IPRLADIDSSEPHLELVPDTWNVYDVSQFLR-VNDCTAHCDTFSRNKIDGKRLLQLTKDDIMPLL 1206
                 ||..           |.|.||..|:| :..|:.:...|..:.|||:.|..||::.:...:
Human   323 -----DIQK-----------WTVDDVHSFIRSLPGCSDYAQVFKDHAIDGETLPLLTEEHLRGTM 371

  Fly  1207 GMKVGPALKISDLIAQ 1222
            |:|:||||||...::|
Human   372 GLKLGPALKIQSQVSQ 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT	542..647	CDD:214723
		MBT	658..753	CDD:214723
		MBT	767..871	CDD:214723
		MBT	882..975	CDD:214723	1/2 (50%)
		TonB_N	<975..1040	CDD:292650	13/69 (19%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979	23/64 (36%)
		SAM	1160..1224	CDD:197735	23/64 (36%)
SAMD7	NP_001291295.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..207		5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..277		9/51 (18%)
		SAM_Samd7,11	324..391	CDD:188978	24/75 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149796
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840