DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sfmbt and L3mbtl2

DIOPT Version :9

Sequence 1:	NP_001137821.1	Gene:	Sfmbt / 34709	FlyBaseID:	FBgn0032475	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	XP_008763933.1	Gene:	L3mbtl2 / 300320	RGDID:	1308569	Length:	728	Species:	Rattus norvegicus

Alignment Length:	809	Identity:	285/809 - (35%)
Similarity:	397/809 - (49%)	Gaps:	183/809 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 TENT-SSKQMQRT----------YSTAKGANSTATTATCS--ASTSSALRSQRKTRKIEPVNRPG 303
            ||.| ||:.|:..          |.:.:..||:|.:.:.|  ..:|.|....|:.         |
  Rat     7 TEETPSSEPMEEEEDDDLELFGGYDSFRSYNSSAGSESSSYLEESSEAENEDREA---------G 62

  Fly   304 LVLKTPIAYRGNIDPSVIPIQKDGMAVCKRCGAIGVKHTFYTKSRRFCSMACARGELYSLVLNTK 368
            .:..:|:....:.:...:.......|||:.||.:|.:..|::|::||||::|:|.  ||  .|:|
  Rat    63 ELPTSPLHLFSSANNRALDGSGSEPAVCEMCGIVGTREAFFSKTKRFCSVSCSRS--YS--SNSK 123

  Fly   369 MEGDQATTSSPDPGAGSESADLPGDQQQSQSDIELDLHAAHIKNANYRFRITDQSKITQLNSFGE 433
            .....|......|                                      |.::|:..
  Rat   124 KASILARLQGKPP--------------------------------------TKKAKVLH------ 144

  Fly   434 PMSMGGDAAANNVQMAADETIAALNGGAVGDATAPGSTEEGASTPNSYLSAAPTPKALRLFKDIY 498
                   .||.:.::.|  .:.|...|.:.|.|..|
  Rat   145 -------KAAWSAKIGA--FLHAQGTGQLADGTPTG----------------------------- 171

  Fly   499 PQDDLPQIPKYERLPVPCPQMEKIISIRRRMYDPTHSYDWLPRLSKENFNAAPVTCFPHAPGCEV 563
             ||.|                             ...:||...|...::.||||.||.|.|..:.
  Rat   172 -QDAL-----------------------------VLGFDWGKFLKDHSYKAAPVGCFKHVPLYDQ 206

  Fly   564 WDNLGVGMKVEVENTDCDSIEVIQPGQTPTSFWVATILEIKGYKALMSYEGFDTD-SHDFWVNLC 627
            |:::..||||||.|:|     .:.|.:.   :|:||:::..||:.|:.||||:.| |||||.||.
  Rat   207 WEDVMKGMKVEVLNSD-----AVLPSRV---YWIATVIQAAGYRVLLRYEGFENDASHDFWCNLG 263

  Fly   628 NAEVHSVGWCATRGKPLIPPRTIEHKYKDWKDFLVGRLSGARTLPSNFYNKINDSLQSRFRLGLN 692
            ..:||.:||||...|.|:|||||..|:.|||.:|:.||.|:||||::|:.|:.:|::..||.|:.
  Rat   264 TVDVHPIGWCAINSKILVPPRTIHAKFTDWKSYLMKRLVGSRTLPADFHIKMVESMKYPFRQGMR 328

  Fly   693 LECVDKDRISQVRLATVTKIVGKRLFLRY--FDSDDGFWCHEDSPIIHPVGWATTVGHNLAAPQD 755
            ||.|||.::|:.|:|.|..::|.||.|.|  .||||.||||..||:||||||:..|||.:
  Rat   329 LEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGI----- 388

  Fly   756 YLERMLAGREAMIEVHED------DATIELFKMNFTFDEYYSDGKTNSFVEGMKLEAVDPLNLSS 814
                .::.|...:..|..      ||...|||   .....|::|  ..|.|||||||:|||||.:
  Rat   389 ----KMSERRCDMSHHPTFRKIYCDAVPYLFK---KVRAVYTEG--GWFEEGMKLEAIDPLNLGN 444

  Fly   815 ICPATVMAVLKFGYMMIRIDSYQPDASGSDWFCYHEKSPCIFPAGFCSVNNISVTPPNGYDSRTF 879
            ||.||:..||..||:||.:|. .|...||||||||..|..||||.||..|:|.:|||.||:::.|
  Rat   445 ICVATICKVLLDGYLMICVDG-GPSTDGSDWFCYHASSHAIFPATFCQKNDIELTPPKGYETQPF 508

  Fly   880 TWEGYLRDTGAVAAGQHLFHRIIPDHGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGW 944
            .||.||..|.:.||...||:...|:|||:|||.||..|||:|||:|||||.|||.|||.:|||||
  Rat   509 DWESYLEKTKSKAAPARLFNMDCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGW 573

  Fly   945 TDEYDQWLDCESADIYPVGWCVLVNHKLEGPPRVAHQQAPKPAPKPKIQRKRKPKK-GAAGGKTP 1008
            .:|||||:||||.||||||||.|..::|: ||..|....|:   |.|...|:|.|: |....:.|
  Rat   574 DNEYDQWVDCESPDIYPVGWCELTGYQLQ-PPVSAEPNTPQ---KGKDATKKKKKQFGKKRKRIP 634

  Fly  1009 TDNNTQSVKSRTIALKTTPHLPKLSIKLE 1037
            :        ::|..|:.:...|.|...||
  Rat   635 S--------AKTRPLRQSSKKPLLEDNLE 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT	542..647	CDD:214723	45/105 (43%)
		MBT	658..753	CDD:214723	48/96 (50%)
		MBT	767..871	CDD:214723	51/109 (47%)
		MBT	882..975	CDD:214723	58/92 (63%)
		TonB_N	<975..1040	CDD:292650	17/64 (27%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979
		SAM	1160..1224	CDD:197735
L3mbtl2	XP_008763933.1	MBT	183..283	CDD:214723	45/107 (42%)
		MBT	294..390	CDD:214723	48/104 (46%)
		MBT	433..504	CDD:280910	42/71 (59%)
		MBT	511..604	CDD:214723	58/93 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6300
eggNOG	1	0.900	-	-		E1_KOG3766
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	508	1.000	Inparanoid score	I1277
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002222
OrthoInspector	1	1.000	-	-		otm45065
orthoMCL	1	0.900	-	-		OOG6_105853
Panther	1	1.100	-	-	LDO	PTHR12247
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1465
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.820