DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sfmbt and L3MBTL1

DIOPT Version :9

Sequence 1:	NP_001137821.1	Gene:	Sfmbt / 34709	FlyBaseID:	FBgn0032475	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001364232.1	Gene:	L3MBTL1 / 26013	HGNCID:	15905	Length:	862	Species:	Homo sapiens

Alignment Length:	927	Identity:	206/927 - (22%)
Similarity:	318/927 - (34%)	Gaps:	299/927 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   378 SPDPGAGSESAD---LP----GDQQQSQSDIEL---DLHAAHIKNANYRFRITD----------- 421
            :|:..||.|...   ||    |....|.|.:.|   ...||.......||||::
Human    72 APEQVAGCEPVSATVLPQLSAGPASSSTSTVRLLEWTEAAAPPPGGGLRFRISEYKPLNMAGVEQ 136

  Fly   422 -------QSKITQLNSFGEPMSMGGDAAAN---------------NVQMAADETIAALNGGAVGD 464
                   |..:|:....|.|   .||..|.               |.....|::...........
Human   137 PPSPELRQEGVTEYEDGGAP---AGDGEAGPQQAEDHPQNPPEDPNQDPPEDDSTCQCQACGPHQ 198

  Fly   465 ATAP--GSTEEG----------------ASTPNSYLSAAPTPKALRLFKDIYPQDDLPQ-IPKYE 510
            |..|  ||:.:|                .||..|.|......:..|.::....::..|: :.|.|
Human   199 AAGPDLGSSNDGCPQLFQERSVIVENSSGSTSASELLKPMKKRKRREYQSPSEEESEPEAMEKQE 263

  Fly   511 RLPVP-------CPQMEKIISIRRRMYDPTHSYDWLPRLSKENFNAAPVTCFPHAPGCEVWDN-L 567
            ....|       .|:.|:..|.:....:....:.|...|.::....|||:.|..:.......| .
Human   264 EGKDPEGQPTASTPESEEWSSSQPATGEKKECWSWESYLEEQKAITAPVSLFQDSQAVTHNKNGF 328

  Fly   568 GVGMKVEVENTDCDSIEVIQPGQTPTSFWVATILEIKGYKALMSYEGFDTDSHDFWVNLCNAEVH 632
            .:|||          :|.|.| |.|:.:::.|:.|:.||:..:.::|: ::.||||||..:.::|
Human   329 KLGMK----------LEGIDP-QHPSMYFILTVAEVCGYRLRLHFDGY-SECHDFWVNANSPDIH 381

  Fly   633 SVGWCATRGKPLIPPRTIEHKYKDWKDFLVGRLSGARTLPSN-FYNKINDSLQSRFRLGLNLECV 696
            ..||....|..|.||:..:.:...|..:|  |.:.|:..|.: |.::.:......|::|:.||.|
Human   382 PAGWFEKTGHKLQPPKGYKEEEFSWSQYL--RSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAV 444

  Fly   697 DKDRISQVRLATVTKIVGKRLFLRYFDS-DD--GFWCHEDSPIIHPVGWATTVGHNLAAPQDYLE 758
            |:...|.|.:|:||.:|..| ||.:||: ||  .:||...||.||||||....|..|..||||
Human   445 DRMNPSLVCVASVTDVVDSR-FLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDY-- 506

  Fly   759 RMLAGREAMIEVHEDDATIELFKMNFTFDEYYSDGKTNSFVEGMKLEAVDPLNLSSICPATVMAV 823

Human   507 ----------------------------------------------------------------- 506

  Fly   824 LKFGYMMIRIDSYQPDASGSDWFCYHEKSPCIFPAGFCSVNNISVTPPNGYDSRTFTWEGYLRDT 888
                          ||                 |..||                   ||.||.:|
Human   507 --------------PD-----------------PDNFC-------------------WEKYLEET 521

  Fly   889 GAVAAGQHLFHRIIPDHGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWLD 953
            ||.|.....| ::.|.|.|.|.|.||..|..:|.|:.||:|..|....:|:|||||:..||.|:|
Human   522 GASAVPTWAF-KVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWID 585

  Fly   954 CESADIYPVGWCVLVNHKLEGPPRVAHQQAPKPAPKPKIQRKRKPKKGAAGGKTPTDNNTQSVKS 1018
            .:..||:|.|||....|.|:          |...|       |:|...:.||..|
Human   586 ADHPDIHPAGWCSKTGHPLQ----------PPLGP-------REPSSASPGGCPP---------- 623

  Fly  1019 RTIALKTTPH--LPKLSIKLELKPEHHNAAFYENNQPEEEGDEEDPDADGDGDGSTSHISEQSTT 1081
              ::.::.||  ..|.|.       ||...             ..|..||.|     |::.:.|.
Human   624 --LSYRSLPHTRTSKYSF-------HHRKC-------------PTPGCDGSG-----HVTGKFTA 661

  Fly  1082 -----------QSSSDLIAGSGSGSGSASLVTLATGSNKTVKKSTTKSPAPP---TVGRKATSYI 1132
                       ::.|.|.|.......||....|:..|.:...:...:...||   .:.::....:
Human   662 HHCLSGCPLAERNQSRLKAELSDSEASARKKNLSGFSPRKKPRHHGRIGRPPKYRKIPQEDFQTL 726

  Fly  1133 ANSSATNNKYIPRL-ADIDSS-----EPHLELVPDT----------WNVYDVSQFLRVNDCTAHC 1181
            .......:.::..| |..|.|     |.|.:|:|..          |.:.:|..|::.   ...|
Human   727 TPDVVHQSLFMSALSAHPDRSLSVCWEQHCKLLPGVAGISASTVAKWTIDEVFGFVQT---LTGC 788

  Fly  1182 DTFSRNKIDGKRLLQLT 1198
            :..:|...|..|::::|
Human   789 EDQARLFKDEARIVRVT 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT	542..647	CDD:214723	30/105 (29%)
		MBT	658..753	CDD:214723	36/98 (37%)
		MBT	767..871	CDD:214723	5/103 (5%)
		MBT	882..975	CDD:214723	40/92 (43%)
		TonB_N	<975..1040	CDD:292650	11/66 (17%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979	9/49 (18%)
		SAM	1160..1224	CDD:197735	9/49 (18%)
L3MBTL1	NP_001364232.1	PRK07764	<27..188	CDD:236090	25/118 (21%)
		MBT	299..396	CDD:214723	30/108 (28%)
		MBT	407..503	CDD:214723	36/98 (37%)
		MBT	515..607	CDD:214723	40/102 (39%)
		zf-C2HC	643..671	CDD:396216	6/45 (13%)
		SAM_superfamily	770..>798	CDD:417767	5/30 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149799
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3766
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740