Protein Alignment Sfmbt and L3mbtl3

DIOPT Version :10

• Sequence 1: NP_001137821.1
• Gene: Sfmbt / 34709
• FlyBaseID: FBgn0032475
• Length: 1243
• Species: Drosophila melanogaster
• Sequence 2: NP_766375.1
• Gene: L3mbtl3 / 237339
• MGIID: 2143628
• Length: 883
• Species: Mus musculus
• Alignment Length: 1125
• Identity: 225/1125 - (20%)
• Similarity: 368/1125 - (32%)
• Gaps: 413/1125 - (36%)

  Fly   237 MGTLNG-------NAFGNIMVSTENTSSKQMQRTYSTAKGANSTATTATCSASTSSALRSQRKTR 294
            :|||.|       |.||.:.|.|:.:..:.:::         :||||.....:...|..|...:|
Mouse    25 VGTLPGSDLKFRVNEFGALEVITDESEMESVKK---------ATATTTWMVPTAQDAPTSPPSSR 80

  Fly   295 KIEP----VNRPGLVL----KTPIAYRGNIDPSVIPIQKDGMAVCKRCGAIGVKHTFYTKSRRFC 351
            .:.|    .:.||...    ||.:.:|.....     :.||:..|:.|...| .........::|
Mouse    81 PVFPPAYWTSPPGCPTVFSEKTGVPFRLKEQS-----KADGLQFCENCCQYG-NGDECLSGGKYC 139

  Fly   352 SMACARGELYSLVLNTKMEGDQA-TTSSPDPGAG-------SESADLPGDQQQSQSDIELDLHAA 408
            |..|||   ::...:.|.|.|.. .....||...       |..||...|.::...::| :....
Mouse   140 SQNCAR---HAKDKDQKDERDGGEDNDEEDPKCSRKKKPKLSLKADSKDDGEERDDEME-NKQDG 200

  Fly   409 HIKNANYRFRITDQSKITQLNSFGEPMSMGGDAAANNVQMAADETIAALNGGAVGDATAPGSTEE 473
            .|...:.|.|                ....||:|                      ....|...:
Mouse   201 RILRGSQRAR----------------RKRRGDSA----------------------VLKQGLPPK 227

  Fly   474 GAST--PNSYLSAAPTPKALRLFKDIYPQDDLPQIPKYERLPVPCPQMEKIISIRRRMYDPTHSY 536
            |..|  ..|||                                   :.||.:::..:::....|:
Mouse   228 GKKTWCWASYL-----------------------------------EEEKAVAVPTKLFKEHQSF 257

  Fly   537 DWLPRLSKENFNAAPVTCFPHAPGCEVWDNLGVGMKVEVENTDCDSIEVIQPGQTPTSFWVATIL 601
            .:    :|..|.                    ||||:|..:.|..::           :.|.|:.
Mouse   258 PY----NKNGFK--------------------VGMKLEGVDPDHQAM-----------YCVLTVA 287

  Fly   602 EIKGYKALMSYEGFDTDSHDFWVNLCNAEVHSVGWCATRGKPLIPPRTIEHKYKDWKDFLVGRLS 666
            |:.||:..:.::|: :|.:|||||....::|.||||...|..|.||:..:.:..:|:.:|  :..
Mouse   288 EVCGYRIKLHFDGY-SDCYDFWVNADALDIHPVGWCEKTGHKLRPPKGYKEEEFNWQSYL--KTC 349

  Fly   667 GARTLPSNFYNKINDS-LQSRFRLGLNLECVDKDRISQVRLATVTKIVGKRLFLRYFDSDD---G 727
            .|:..|.:.:...|.: :.|.||:|:.||..||...|.:.:||||.:|..| ||.:||:.|   .
Mouse   350 KAQAAPKSLFENQNITVIPSGFRVGMKLEAADKKSPSVICVATVTDMVDNR-FLVHFDNWDESYD 413

  Fly   728 FWCHEDSPIIHPVGWATTVGHNLAAPQDYLERMLAGREAMIEVHEDDATIELFKMNFTFDEYYSD 792
            :||..:||.||||||
Mouse   414 YWCESNSPHIHPVGW-------------------------------------------------- 428

  Fly   793 GKTNSFVEGMKLEAVDPLNLSSICPATVMAVLKFGYMMIRIDSYQPDASGSDWFCYHEKSPCIFP 857
                                                                  |...:...|.|
Mouse   429 ------------------------------------------------------CKEHRRTLITP 439

  Fly   858 AGFCSVNNISVTPPNGYDSRTFTWEGYLRDTGAVAAGQHLFHRIIPDHGFEVGMSLECADLMDPR 922
            .|:..|.:             |:|:.||.:|.::.|....| ::.|.|||:..|.||..|..:|.
Mouse   440 PGYSHVKH-------------FSWDKYLEETNSLPAPARAF-KVKPPHGFQKKMKLEAVDKRNPL 490

  Fly   923 LVCVATVARVVGRLLKVHFDGWTDEYDQWLDCESADIYPVGWCVLVNHKLEGPPRVAHQQAPK-- 985
            .:.|||||......:|||||||:..||.|:|.:|.||:|||||....|.|:.|...|....|.
Mouse   491 FIRVATVADTDDHRIKVHFDGWSSCYDYWIDADSPDIHPVGWCSKTGHPLQAPLSPAELMEPSET 555

  Fly   986 ----------------------------PAPKPKIQRKRKPKKGAAGGKTPTDNNTQSVKSRTIA 1022
                                        |..:..:.::|......:|..:|
Mouse   556 GGCPTLGCRGVGHFKKSRYLGTQSGANCPYSEINLSKERIFPDRLSGDTSP-------------- 606

  Fly  1023 LKTTPHLPKLSIKLELKP--------EHHNAAFYENNQPEEEGD----------EEDPDADGDGD 1069
             .|||..|: |.:::.:.        |.|...|.|:::.::|.:          .|:|.......
Mouse   607 -PTTPSFPR-SKRMDTRESSSSPETREKHANNFKEDSEKKKENEVKTSAEAKVVREEPTPSVQQS 669

  Fly  1070 GSTSHISEQSTTQSSSDLIAGSGSGSGSASLVTLATGSNKTVKKSTTKSP--------------- 1119
            .....:.:....|...     ....:..|.....|..:.:..:...|..|
Mouse   670 QPPQQVQQVQHAQPPQ-----QAQKAPQAQQAQQAQQAQQAPQAPQTPQPQQAPQVQQAQQAPQA 729

  Fly  1120 --------------------------APPTVGRKATSYIANSSAT------------------NN 1140
                                      |.||..:..|...|...:.                  .:
Mouse   730 QQAQQPQQAQQPQQAPPVQQPQQVQQAQPTQQQAQTQQQAQRRSAVFLSFKPPIPCLPLRWEQQS 794

  Fly  1141 KYIPRLADIDSSEPHLELVPDTWNVYDVSQFLR-VNDCTAHCDTFSRNKIDGKRLLQLTKDDIMP 1204
            |.:|.:|.|.:|.      ...|:..:||:|:: :..|..|...|...:|||:..|.:|:.||:.
Mouse   795 KLLPTVAGIPASR------VSKWSTDEVSEFIQSLPGCEEHGKVFKDEQIDGEAFLLMTQTDIVK 853

  Fly  1205 LLGMKVGPALKISDLIAQLK 1224
            ::.:|:||||||.:.|...|
Mouse   854 IMSIKLGPALKIFNSILMFK 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT_dSfmbt_rpt1	564..672	CDD:439109	30/107 (28%)
		MBT_dSfmbt_rpt2	674..753	CDD:439112	31/82 (38%)
		MBT_dSfmbt_rpt3	798..904	CDD:439115	12/105 (11%)
		MBT_dSfmbt_rpt4	905..976	CDD:439118	34/70 (49%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979	23/66 (35%)
L3mbtl3	NP_766375.1	Interaction with RBPJ. Required for transcription repressor activity on Notch target genes. /evidence=ECO:0000250|UniProtKB:Q96JM7	1..64		13/47 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	146..223		16/115 (14%)
		MBT 1	232..332		33/170 (19%)
		MBT_L3MBTL3_rpt1	259..359	CDD:439122	33/137 (24%)
		MBT 2	340..439		37/205 (18%)
		MBT_L3MBTL3_rpt2	366..458	CDD:439125	39/209 (19%)
		MBT 3	448..543		42/95 (44%)
		MBT_L3MBTL3_rpt3	467..544	CDD:439128	36/77 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	595..768		23/193 (12%)
		SAM_Scm-like-3MBT3,4	808..873	CDD:188981	22/64 (34%)