Protein Alignment Sfmbt and L3mbtl2

DIOPT Version :10

• Sequence 1: NP_001137821.1
• Gene: Sfmbt / 34709
• FlyBaseID: FBgn0032475
• Length: 1243
• Species: Drosophila melanogaster
• Sequence 2: NP_001276640.1
• Gene: L3mbtl2 / 214669
• MGIID: 2443584
• Length: 739
• Species: Mus musculus
• Alignment Length: 819
• Identity: 286/819 - (34%)
• Similarity: 401/819 - (48%)
• Gaps: 176/819 - (21%)

  Fly   253 ENTSSKQMQRT----------YSTAKGANSTATTATCS--ASTSSALRSQRKTRKIEPVNRPGLV 305
            |..||:.|:..          |.:.:..||:|.:.:.|  ..:|.|....|:.         |.:
Mouse     9 EAPSSEPMEEEEEDDLDLFGGYDSFRSYNSSAGSESSSYLEESSEAENEDREA---------GEL 64

  Fly   306 LKTPIAYRGNIDPSVIPIQKDGMAVCKRCGAIGVKHTFYTKSRRFCSMACARGELYSLVLNTKME 370
            ..:|:....:.:...:.......|||:.||.:|.:..|::|::||||::|:|.  ||  .|:|..
Mouse    65 PTSPLHLFSSANNRSLDGSGSEPAVCEMCGIVGTREAFFSKTKRFCSVSCSRS--YS--SNSKKA 125

  Fly   371 GDQATTSSPDPGAGSESADLPGDQQQSQSDIELDLHAAHIKNANYRFRITDQSKITQLNSFGEPM 435
            ...|......|                                      |.::|:..
Mouse   126 SILARLQGKPP--------------------------------------TKKAKVLH-------- 144

  Fly   436 SMGGDAAANNVQMAADETIAALNGGAVGDATAPGSTEEGASTPNSYLSAAPTPKALRLFKDIYPQ 500
                 .||.:.::.|  .:.|...|.:.|.|..|                              |
Mouse   145 -----KAAWSAKIGA--FLHAQGTGQLADGTPTG------------------------------Q 172

  Fly   501 DDLPQIPKYERLPVPCPQMEKIISIRRRMYDPTHSYDWLPRLSKENFNAAPVTCFPHAPGCEVWD 565
            |.|                             ...:||...|...::.||||:||.|.|..:.|:
Mouse   173 DAL-----------------------------VLGFDWGKFLKDHSYKAAPVSCFKHVPLYDQWE 208

  Fly   566 NLGVGMKVEVENTDCDSIEVIQPGQTPTSFWVATILEIKGYKALMSYEGFDTD-SHDFWVNLCNA 629
            ::..||||||.|:|     .:.|.:.   :|:||:::..||:.|:.||||:.| |||||.||...
Mouse   209 DVMKGMKVEVLNSD-----AVLPSRV---YWIATVIQAAGYRVLLRYEGFENDASHDFWCNLGTV 265

  Fly   630 EVHSVGWCATRGKPLIPPRTIEHKYKDWKDFLVGRLSGARTLPSNFYNKINDSLQSRFRLGLNLE 694
            :||.:||||...|.|:|||||..|:.|||.:|:.||.|:||||::|:.|:.:|::..||.|:.||
Mouse   266 DVHPIGWCAINSKILVPPRTIHAKFTDWKSYLMKRLVGSRTLPADFHIKMVESMKYPFRQGMRLE 330

  Fly   695 CVDKDRISQVRLATVTKIVGKRLFLRY--FDSDDGFWCHEDSPIIHPVGWATTVGHNLAAPQDYL 757
            .|||.::|:.|:|.|..::|.||.|.|  .||||.||||..||:||||||:..|||.:
Mouse   331 VVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGI------- 388

  Fly   758 ERMLAGREAMIEVHED------DATIELFKMNFTFDEYYSDGKTNSFVEGMKLEAVDPLNLSSIC 816
              .::.|...:..|..      ||...|||   .....|::|  ..|.|||||||:|||||.|||
Mouse   389 --KMSDRRCDMSHHPTFRKIYCDAVPYLFK---KVRAVYTEG--GWFEEGMKLEAIDPLNLGSIC 446

  Fly   817 PATVMAVLKFGYMMIRIDSYQPDASGSDWFCYHEKSPCIFPAGFCSVNNISVTPPNGYDSRTFTW 881
            .||:..||..||:||.:|. .|...||||||||..|..||||.||..|:|.:|||.||:::.|.|
Mouse   447 VATICKVLLDGYLMICVDG-GPSTDGSDWFCYHASSHAIFPATFCQKNDIELTPPKGYETQPFAW 510

  Fly   882 EGYLRDTGAVAAGQHLFHRIIPDHGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTD 946
            |.||..|.:.||...||:...|:|||:|||.||..|||:|||:|||||.|||.|||.:|||||.:
Mouse   511 ETYLEKTKSKAAPARLFNMDCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDN 575

  Fly   947 EYDQWLDCESADIYPVGWCVLVNHKLEGPPRVAHQQAP---KPAPKPKIQRKRKPKKGAAGGKT- 1007
            |||||:||||.||||||||.|..::|: ||..|....|   |...|.|.::..|.:|.....||
Mouse   576 EYDQWVDCESPDIYPVGWCELTGYQLQ-PPVSAEPNTPQKGKDTTKKKKKQFGKKRKRIPSAKTR 639

  Fly  1008 PTDNNTQS--VKSRTIALKTTPHLPKLSIKLELKPEHHN 1044
            |....::.  ::....||..:..:|...|.:.:|.||.:
Mouse   640 PLRQGSKKPLLEDNLEALGVSEPVPDDIIAVCVKEEHQD 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT_dSfmbt_rpt1	564..672	CDD:439109	51/108 (47%)
		MBT_dSfmbt_rpt2	674..753	CDD:439112	39/80 (49%)
		MBT_dSfmbt_rpt3	798..904	CDD:439115	58/105 (55%)
		MBT_dSfmbt_rpt4	905..976	CDD:439118	49/70 (70%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979
L3mbtl2	NP_001276640.1	MBT_L3MBTL2_rpt1	207..308	CDD:439111	51/108 (47%)
		MBT_L3MBTL2_rpt2	310..393	CDD:439114	39/91 (43%)
		MBT	428..518	CDD:459242	53/90 (59%)
		MBT_dSfmbt-like_rpt4	534..604	CDD:439090	49/70 (70%)