Protein Alignment Sfmbt and SCML2

DIOPT Version :10

• Sequence 1: NP_001137821.1
• Gene: Sfmbt / 34709
• FlyBaseID: FBgn0032475
• Length: 1243
• Species: Drosophila melanogaster
• Sequence 2: NP_006080.1
• Gene: SCML2 / 10389
• HGNCID: 10581
• Length: 700
• Species: Homo sapiens
• Alignment Length: 697
• Identity: 161/697 - (23%)
• Similarity: 233/697 - (33%)
• Gaps: 272/697 - (39%)

  Fly   775 ATIELFKMNFTFDEYYSD----------------GKTNSFVEGMKLEAVDPLNLSSICPATVMAV 823
            :|..:.:.:|.::||..:                ...|.|..||||||.||.|.:|:|.|||:.:
Human    24 STSSVQRDDFHWEEYLKETGSISAPSECFRQSQIPPVNDFKVGMKLEARDPRNATSVCIATVIGI 88

  Fly   824 LKFGYMMIRIDSYQPDASGSD-----WFCYHEKSPCIFPAGFCSVNNISVTPPNGYDSRTFTWEG 883
            .. ..:.:|:|       |||     |...  .||.|.|.|.|......:.||.||...|.:|..
Human    89 TG-ARLRLRLD-------GSDNRNDFWRLV--DSPDIQPVGTCEKEGDLLQPPLGYQMNTSSWPM 143

  Fly   884 YLRDT--GAVAAGQHLFHRIIPD---HGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDG 943
            :|..|  |:..|...||.:..|.   :.|:|||.||..|..:|.|:|.||:..|.|..:.:.|||
Human   144 FLLKTLNGSEMASATLFKKEPPKPPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDG 208

  Fly   944 WTDEYDQWLDCESADIYPVGWCVLVNHKLEGP----------------PRVAHQQA--------- 983
            |:..:|.|...:|.||:|.|||.|....|:.|                |..|.|.:
Human   209 WSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGTSVPIVKNIAKTESSPSEASQHSMQSPQKTTL 273

  Fly   984 ---------------PKPAPKPK--------IQRKRKPKKGAAGGKTPT--DNNTQSVKSRT--- 1020
                           |.|...||        ..||:.|..|......|.  ..:..|:||.|
Human   274 ILPTQQVRRSSRIKPPGPTAVPKRSSSVKNITPRKKGPNSGKKEKPLPVICSTSAASLKSLTRDR 338

  Fly  1021 -------------IALKTT-----------PHL-PK-------------------------LSIK 1035
                         |.:.|.           ||| ||                         :...
Human   339 GMLYKDVASGPCKIVMSTVCVYVNKHGNFGPHLDPKRIQQLPDHFGPGPVNVVLRRIVQACVDCA 403

  Fly  1036 LE-------LKPEH--------------------------------------------------- 1042
            ||       |||::
Human   404 LETKTVFGYLKPDNRGGEVITASFDGETHSIQLPPVNSASFALRFLENFCHSLQCDNLLSSQPFS 468

  Fly  1043 ------HNAAFYENNQPEEE--------------------------------GDEEDP-DADGDG 1068
                  |::|.::.||..:|                                ..|.:| .|.|..
Human   469 SSRGHTHSSAEHDKNQSAKEDVTERQSTKRSPQQTVPYVVPLSPKLPKTKEYASEGEPLFAGGSA 533

  Fly  1069 DGSTSHISEQSTTQSSSDLIAGSGSGSGSASLVTLATGSNKTVKKSTTKSPAPPTVG-------- 1125
            .....::||.|   .||.|.:|:.......:.:.:.|..::...:|...:.:.|.||
Human   534 IPKEENLSEDS---KSSSLNSGNYLNPACRNPMYIHTSVSQDFSRSVPGTTSSPLVGDISPKSSP 595

  Fly  1126 --------RK--ATSYIANSSATNNKYIPRLADIDSSEPHLELVPDTWNVYDVSQFLRVNDCTAH 1180
                    ||  |.||||         :|   |....:......|.||:|.:|.||::..|....
Human   596 HEVKFQMQRKSEAPSYIA---------VP---DPSVLKQGFSKDPSTWSVDEVIQFMKHTDPQIS 648

  Fly  1181 ---CDTFSRNKIDGKRLLQLTKDDIMPLLGMKVGPALKISDLIAQLK 1224
               .|.|.:::||||.|..|..|.:|..:|:|:|||||:...|.:||
Human   649 GPLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKLCYYIEKLK 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT_dSfmbt_rpt1	564..672	CDD:439109
		MBT_dSfmbt_rpt2	674..753	CDD:439112
		MBT_dSfmbt_rpt3	798..904	CDD:439115	39/112 (35%)
		MBT_dSfmbt_rpt4	905..976	CDD:439118	30/86 (35%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979	28/68 (41%)
SCML2	NP_006080.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		1/8 (13%)
		MBT	33..162	CDD:459242	43/138 (31%)
		MBT 1	33..131		31/107 (29%)
		MBT 2	139..240		37/100 (37%)
		MBT_SCML2_rpt2	167..243	CDD:439099	30/75 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	253..320		11/66 (17%)
		RBR	277..324	CDD:465382	9/46 (20%)
		SLED	356..465	CDD:463469	11/108 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	466..550		14/86 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	575..594		4/18 (22%)
		SAM_Scm	625..696	CDD:188977	28/71 (39%)