DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sfmbt and Mbtd1

DIOPT Version :9

Sequence 1:	NP_001137821.1	Gene:	Sfmbt / 34709	FlyBaseID:	FBgn0032475	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	XP_006531947.1	Gene:	Mbtd1 / 103537	MGIID:	2143977	Length:	736	Species:	Mus musculus

Alignment Length:	852	Identity:	288/852 - (33%)
Similarity:	408/852 - (47%)	Gaps:	213/852 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 TCSASTSSALRSQRKTRKIEPVNRPGLVLKTPIAYRGNIDPSVIPIQKDGMAVCKRCGAIGVKHT 342
            :||..|||:..|:....::.|     |....|| .:.|......|..|.|||.|:.||.:||:..
Mouse    46 SCSEDTSSSSSSEESEEEVAP-----LPSNLPI-IKNNGQVYTYPDGKSGMATCEMCGMVGVRDA 104

  Fly   343 FYTKSRRFCSMACARGELYSLVLNTKMEGDQATTSSPDPGAGSESADLPGDQQQSQSDIELDLHA 407
            ||:|::||||::|:|.  ||                    :.|:.|.:
Mouse   105 FYSKTKRFCSVSCSRS--YS--------------------SNSKKASI----------------- 130

  Fly   408 AHIKNANYRFRITDQSKITQLNSFGEPMSMGGDAAANNVQMAADETIAALNGGAVGDATAPGSTE 472
                             :.:|...|:|
Mouse   131 -----------------LARLQVTGKP-------------------------------------- 140

  Fly   473 EGASTPNSYLSAAPTPKALRLFKDIYPQDDLPQIPKYERLPVPCPQMEK------IISIRRRMYD 531
                         ||.||    |.:..|..:.::..|.:.........|      .||:
Mouse   141 -------------PTKKA----KVLQKQPLVAKLAAYAQYQATLQNQAKTKAGNSAISV------ 182

  Fly   532 PTHSYDWLPRLSKENFNAAPVTCFPHAPGCEVWDNLGVGMKVEVENTDCDSIEVIQPGQTPTS-F 595
              ..:.|...::..:|.||||.||.|||....|.::...:::||.||||         ..||. |
Mouse   183 --EGFSWGNYINSNSFIAAPVACFKHAPMGTCWGDISENVRIEVPNTDC---------SLPTKVF 236

  Fly   596 WVATILEIKGYKALMSYEGFDTDSH-DFWVNLCNAEVHSVGWCATRGKPLIPPRTIEHKYKDWKD 659
            |:|.|:::.||.||:.||||:.||. |||.|:|.:::|.|||||..||||:||||::|||.:||.
Mouse   237 WIAGIIKLAGYNALLRYEGFENDSSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQHKYTNWKA 301

  Fly   660 FLVGRLSGARTLPSNFYNKINDSLQSRFRLGLNLECVDKDRISQVRLATVTKIVGKRLFLRYFDS 724
            |||.||:||:|||.:|..|:::|:|..|:..:.:|.|||..:.:.|:|.|..::|.||.|.|.:|
Mouse   302 FLVKRLTGAKTLPPDFSQKVSESMQYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEES 366

  Fly   725 D---DGFWCHEDSPIIHPVGWATTVGH-----NLAAPQDYLERMLAGR-----EAMIEVHEDDAT 776
            :   |.||||..||:||.:||:.::||     ::...||       |.     ....:|.|.|.:
Mouse   367 EDRTDDFWCHMHSPLIHHIGWSRSIGHRFKRSDITKKQD-------GHFDTPPHLFAKVKEVDQS 424

  Fly   777 IELFKMNFTFDEYYSDGKTNSFVEGMKLEAVDPLNLSSICPATVMAVLKFGYMMIRIDSYQPDAS 841
            .|.||                  |||||||:||||||:||.||:..||..|::||.||..:. |.
Mouse   425 GEWFK------------------EGMKLEAIDPLNLSTICVATIRKVLADGFLMIGIDGSEA-AD 470

  Fly   842 GSDWFCYHEKSPCIFPAGFCSVNNISVTPPNGYDSRTFTWEGYLRDTGAVAAGQHLFHRIIPDHG 906
            ||||||||..||.|||.|||.:|.|.:|||.||....|.|..|||:||::||...||::.:|:||
Mouse   471 GSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKLPFKWFDYLRETGSIAAPVKLFNKDVPNHG 535

  Fly   907 FEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWLDCESADIYPVGWCVLVNHK 971
            |.|||.||..|||:|||:|||||.|::.|||::|||||.:|||||:||||.|:||||||.|..::
Mouse   536 FRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQ 600

  Fly   972 LEGPPRVAHQQAPKPAPKPKIQRK------RKPKKGAAGGKTPT-----------------DNNT 1013
            |:.|...:.:::...:.|.|.:.|      .|.|:....||.|.                 |...
Mouse   601 LQPPASQSSRESQSASSKQKKKAKSQQYKGHKKKRKMPVGKKPVSLSSLPMTGGVRRSFSGDEEL 665

  Fly  1014 QSVKSRTIALKTT-PHLPKLSIKLELKPEHHNAAFYENNQPEEEGDEEDPD-----ADGDGDGS- 1071
            .....||:..:|. ...|..|...|.:|......  .:...||..|.||..     :|.:.:||
Mouse   666 TPPPYRTLPAQTALEAFPPPSTSREFRPSLKTVT--TSQLKEELLDGEDYSFLHGASDQESNGSA 728

  Fly  1072 TSHISEQ 1078
            |.:|.::
Mouse   729 TVYIKQE 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT	542..647	CDD:214723	48/106 (45%)
		MBT	658..753	CDD:214723	42/102 (41%)
		MBT	767..871	CDD:214723	50/103 (49%)
		MBT	882..975	CDD:214723	56/92 (61%)
		TonB_N	<975..1040	CDD:292650	16/88 (18%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979
		SAM	1160..1224	CDD:197735
Mbtd1	XP_006531947.1	MBT	189..289	CDD:214723	48/108 (44%)
		MBT	306..396	CDD:214723	38/89 (43%)
		MBT	403..500	CDD:214723	53/122 (43%)
		MBT	512..604	CDD:214723	56/91 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6448
eggNOG	1	0.900	-	-		E1_KOG3766
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41185
Inparanoid	1	1.050	510	1.000	Inparanoid score	I1308
Isobase	1	0.950	-	0	Normalized mean entropy	S5675
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002222
OrthoInspector	1	1.000	-	-		otm43001
orthoMCL	1	0.900	-	-		OOG6_105853
Panther	1	1.100	-	-	O	PTHR12247
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2614
SonicParanoid	1	1.000	-	-		X1465
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.800