DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sfmbt and l3mbtl3

DIOPT Version :9

Sequence 1:	NP_001137821.1	Gene:	Sfmbt / 34709	FlyBaseID:	FBgn0032475	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	XP_004911641.2	Gene:	l3mbtl3 / 100496330	XenbaseID:	XB-GENE-1219135	Length:	778	Species:	Xenopus tropicalis

Alignment Length:	978	Identity:	218/978 - (22%)
Similarity:	342/978 - (34%)	Gaps:	363/978 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 PGDQQQSQSDIELDLHA---------------------------AHIKNANYRFRITDQSKITQL 428
            ||:::..:||   .||:                           |.:..::.|||         |
Frog     7 PGERRVVRSD---GLHSERWGREMSQGPVSDFDLMNALDWRDGIATLPGSHIRFR---------L 59

  Fly   429 NSFGEPMSMGGDAAANNVQMAADETIAAL---NGGAVGDATAPGS-------------------- 470
            :.||          ...:...:|..:.|.   :|.|.|..|...|
Frog    60 SEFG----------TLEIITDSDSVVTATLPQSGQAFGTDTHTSSVSIFSQVIKIEDKDPEMEKK 114

  Fly   471 -TEEGAST--PNSYLSAAPTPKALRLFKDIYPQDDLPQ-IPKYERLPVPCPQMEKII-------- 523
             |||...|  |......||.|..:......|.:::.|| :.:..:|.:.....|.::
Frog   115 TTEESLPTVQPAEEQPTAPVPPTVASGSSTYIENERPQRLRRKRKLLMDSGDEEDLLDDEEMNHW 179

  Fly   524 -------------SIRRRMYDPTHS--YDWLPRLSKENFNAAPVTCF-PHAPGCEVWDNLGVGMK 572
                         |.:.:...|...  ::|:..|.:|...|.|:.|| .|....:..:|...|||
Frog   180 HDKIKANLKSRKTSKQTKTAPPPKKKLWNWVSYLEEEKMPAVPLKCFKEHQSFPQSRNNFRGGMK 244

  Fly   573 VEVENTDCDSIEVIQPGQTPTSFWVATILEIKGYKALMSYEGFDTDSHDFWVNLCNAEVHSVGWC 637
                      :|.|.| :.|:.:.|.|:.|::||:..:.::|: .|.:|||||..:.::|.||||
Frog   245 ----------LEGIDP-EHPSLYCVLTVAEVQGYRMRLHFDGY-PDCYDFWVNADSVDIHPVGWC 297

  Fly   638 ATRGKPLIPPRTIEHKYKD----WKDFLVGRLSGARTLPSNFYNKINDSL-QSRFRLGLNLECVD 697
            ...|..|:||:    .|||    |..:|  :...|:..|...:...|..: .|.||..:.||.||
Frog   298 ERTGHKLLPPK----GYKDGEFSWAAYL--KHCKAQGAPKTLFKSYNTPVTPSGFRAAMKLEAVD 356

  Fly   698 KDRISQVRLATVTKIVGKRLFLRYFDSDD---GFWCHEDSPIIHPVGWATTVGHNLAAPQDYLER 759
            :...|.:.:||::.||..||.: :|||.|   .:||...||.|.||
Frog   357 RKNPSLLCVATISDIVENRLLI-HFDSWDHSYDYWCDASSPYIRPV------------------- 401

  Fly   760 MLAGREAMIEVHEDDATIELFKMNFTFDEYYSDGKTNSFVEGMKLEAVDPLNLSSICPATVMAVL 824

Frog   402 ----------------------------------------------------------------- 401

  Fly   825 KFGYMMIRIDSYQPDASGSDWFCYHEKSPCIFPAGFCSVNNISVTPPNGY-DSRTFTWEGYLRDT 888
                                              |:|..:.|::|||..| |.:.||||.||..|
Frog   402 ----------------------------------GYCQESAIALTPPPEYKDPKCFTWEAYLEKT 432

  Fly   889 GAVAAGQHLFHRIIPDHGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWLD 953
            ||.||....| :..|.||::..|.||..|..:|.|:.|.:..:.....:|:|||||:..||.|:|
Frog   433 GAQAAPARAF-KPRPPHGYQPQMKLEAVDQRNPMLIRVCSTVQKDDNRIKLHFDGWSSLYDFWVD 496

  Fly   954 CESADIYPVGWCVLVNHKLEGPP------RVAHQQAP---------------------------- 984
            .:|.||:|||||....|.|:.||      .||.|..|
Frog   497 VDSPDIHPVGWCAKTGHALQLPPGASDMAAVAGQGCPIAGCTGIGHVRGSRYGTHYTAVGCPYSE 561

  Fly   985 ----------------KPAPKPKIQRKRKPKKGAAGGKTPTDNNTQSVKSRTIALKTTPHLPKLS 1033
                            :|:|.....|.|:|     |..:||.:::...:||           |..
Frog   562 VNLNRENLLQDRLSGERPSPVQNATRSRRP-----GTPSPTTDSSDFPQSR-----------KSP 610

  Fly  1034 IKLELKPEHHNAAFYENNQPEEEGDEEDPDADGDGDGSTSHISEQSTTQSSSDLIAGSGSGSGSA 1098
            |.:|.:....|.  :|..:..||..|..|...   .||.::|..|...|.:          .|:.
Frog   611 IPVEERWGRSNP--WEGTEWLEEETETKPQIK---RGSHTYIRLQIIKQET----------DGTD 660

  Fly  1099 SLVTLATGSNKTVKKSTTKSPAPPTVGR----------KATSYIANSSATNNKYIPRLADIDSSE 1153
            ..|:|....:::|..::..|.....:..          :.:||.|.|..
Frog   661 CEVSLEQALHQSVFMTSLSSDPGHRIHMCWEQQCYLLPEVSSYTAQSVG---------------- 709

  Fly  1154 PHLELVPDTWNVYDVSQFL-RVNDCTAHCDTFSRNKIDGKRLLQLTKDDIMPLLGMKVGPALKIS 1217
                    .|:..:|:||: ::..||.....|...:|||:..|.||::|::.:||:|:||||||.
Frog   710 --------KWSADEVAQFVHQLPGCTEQSSVFRDEQIDGEAFLLLTQNDLVKILGLKLGPALKIY 766

  Fly  1218 DLI 1220
            :.|
Frog   767 NSI 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sfmbt	NP_001137821.1	MBT	542..647	CDD:214723	34/105 (32%)
		MBT	658..753	CDD:214723	29/98 (30%)
		MBT	767..871	CDD:214723	4/103 (4%)
		MBT	882..975	CDD:214723	39/92 (42%)
		TonB_N	<975..1040	CDD:292650	19/114 (17%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979	24/62 (39%)
		SAM	1160..1224	CDD:197735	24/62 (39%)
l3mbtl3	XP_004911641.2	MBT	211..307	CDD:214723	34/107 (32%)
		MBT	319..414	CDD:214723	33/215 (15%)
		MBT	426..518	CDD:214723	39/92 (42%)
		SAM_Scm-like-3MBT3,4	708..773	CDD:188981	24/86 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910