Protein Alignment ADGRD2 and adgrd2

DIOPT Version :10

• Sequence 1: NP_001382354.1
• Gene: ADGRD2 / 347088
• HGNCID: 18651
• Length: 982
• Species: Homo sapiens
• Sequence 2: XP_021334184.1
• Gene: adgrd2 / 571770
• ZFINID: ZDB-GENE-081104-190
• Length: 1145
• Species: Danio rerio
• Alignment Length: 984
• Identity: 362/984 - (36%)
• Similarity: 511/984 - (51%)
• Gaps: 87/984 - (8%)

Human    56 LSWWQAQESCEQQFGHLAL----QPPDG----VLASRLRDPVWV--GQREAPLRRPPQRRARTTA 110
            ||:.||...|..|...|..    :..||    :..|.|:.|||.  .:|..|...  ..|...|.
Zfish   135 LSFRQALHYCRGQTSVLTTAGVKEDEDGAQQLLNKSNLKGPVWFQSNKRHHPTTH--LERLEKTV 197

Human   111 VLVFDERTADRAARLRSPLPELAALTACTHVQWDCASPDPAALFSVAAPALPNALQLRAFAEPGG 175
            :.....::.:..||:.:..|.|:|.:.|..||||....:.:.:||.|||...|..|||...:...
Zfish   198 LPGLSFKSKEGFARVNATFPPLSAASVCVRVQWDAHHENVSTVFSYAAPVFINEFQLRGQIDESS 262

Human   176 ------VVRAALVVRGQHAPFLAAFRADGRWHHVCATWEQRGGRWALFSDGRRR-AGAR-GLGAG 232
                  .||.||:::|||.|:.|....||.|||||.||....|.||::.||:.. :|.| .|...
Zfish   263 RGQTDRKVRLALLIQGQHHPYKAELSVDGNWHHVCVTWRSSDGFWAIYVDGKTADSGKRDSLQKA 327

Human   233 HPVPSGGILVLGQDQDSLGGGFSVRHALSGNLTDFHLWARALSPAQLHRARACAP-PSEGLLFRW 296
            ..:...||.:||||||:.||  ::.....|||||..:|:.||...|:.....|:| .:...:|||
Zfish   328 KDIHGDGIFILGQDQDTFGG--TLTEPFVGNLTDLSVWSEALELEQVQALNTCSPLTNHRAVFRW 390

Human   297 DPGALDVTPSLLPTVWVRLLCPV-------PSEECPT---WNPGPRSEGSELCLEPQPFLCCYRT 351
            ....|.:..| :..|...|.|||       ..|||..   |:.......|.:|....||:|...|
Zfish   391 RDWNLSIHQS-VQNVSATLSCPVSPKAAQRQQEECEVLKGWSAARPQYSSAVCTHTFPFICRIST 454

Human   352 EPYRRLQD------AQSWPGQDVISRVNALANDIVLLPDPLSEVHGALSPAEASSFLGLLEHVLA 410
            |.|.::::      :...|....:.:....|.|:      ||:.....|.|..|..|.:.|.|:.
Zfish   455 EHYLKMKELRESLRSNPSPFMQSLMQYGMTAEDV------LSDAVDDQSWASVSRLLNVSEQVML 513

Human   411 MEMAPLGPAALLAVVRFLKRVVALGAGDPELLLT-----GPWEQLSQGVVSVASLVLEEQVADTW 470
            .|..||....::::|..|.|..       :|.:|     ...|.|.|..:::|..:|.:...:.|
Zfish   514 TEQKPLEDRDMVSLVHVLSRAA-------DLPITANHSRADAETLGQSFITIADSLLSQDDHEKW 571

Human   471 LSLREVIGGPMALVASVQRLAPLLSTSMTSERPRMRIQHRHAGLEVRSLRLREASTRGCLFTMPG 535
            .|::||:.||||::.:|:|:...|::.:|.:...::|...:..|:|:...|.|...........|
Zfish   572 QSIKEVVKGPMAVIQTVERMGINLNSLLTDDTDSVQIHSHNIKLQVQQKLLSEDPHVSAFCGSDG 636

Human   536 GRPEGPGHIHIPASEVRRLLRKGLSGVTVIHSWFTS-RVFQHTLEGPDLEPQAPASSEEANRVQR 599
            |..:   .|.:||..::.|.......|||:::||:| :......|...|.|.....|      ||
Zfish   637 GNRD---CISVPAKNMKELRNNDFRKVTVLNTWFSSVKCLSEKEENISLFPIVTDGS------QR 692

Human   600 FLSTQVGSAIISSEVWDVTGEVNVAMTFHLQHRAQSPLFPPHPPSPY-------TGGAWATTGCS 657
            |:.|.:||::|||.|......|:||:.|.||||.|:......|...:       .||.|:|.||.
Zfish   693 FVGTVLGSSVISSTVLADEQPVSVAIHFTLQHRLQNTSVKFIPVCAFWDFDLMSDGGGWSTKGCV 757

Human   658 VAALYLDSTACFCNHSTSFAILLQIYEVQRGPEEESLLRTLSFVGCGVSFCALTTTFLLFLVAGV 722
            |.:...:||:|:|||:|:||:|||||||||....::.|:.||.:|..||.|||..||:||:..||
Zfish   758 VISTQNNSTSCYCNHTTNFALLLQIYEVQRDAVHDAGLQILSLIGSAVSLCALIFTFILFVAVGV 822

Human   723 PKSERTTVHKNLTFSLASAEGFLMTSEWAKANEVACVAVTVAMHFLFLVAFSWMLVEGLLLWRKV 787
            |||:||||||||..:|..|:..|:.|:||..::.||..||..:|..||.:|.||||||||||.||
Zfish   823 PKSDRTTVHKNLMAALIVAQFLLILSDWAAGSQEACWLVTALLHLFFLSSFCWMLVEGLLLWSKV 887

Human   788 VAVSMHPGPGMRLYHATGWGVPVGIVAVTLAMLPHDYVAPGHCWLNVHTNAIWAFVGPVLFVLTA 852
            |:|::.....|::|:..|||:||.||||||......|.|..|||||:.::.||||.|||||||..
Zfish   888 VSVNISEDRRMKMYYVLGWGLPVVIVAVTLVATLDQYKAQQHCWLNLQSSVIWAFAGPVLFVLAV 952

Human   853 NTCILARVVMITVSSARRRARMLSPQPCLQQQIWTQIWATVKPVLVLLPVLGLTWLAGILVHLSP 917
            |..:|.|||::|||||||||:||:|....:.......||..:|||:||||||||||.|:|||||.
Zfish   953 NAVVLFRVVLVTVSSARRRAKMLTPSSDSKLHTLDLTWAATRPVLILLPVLGLTWLCGVLVHLSD 1017

Human   918 AWAYAAVGLNSIQGLYIFLVYAACNEEVRSALQRMAEKKVA------EGPMALELPQHSP----- 971
            ..||..:.||:.||||||||||..|.|||:|::|:.||:.|      ..|::....|.||
Zfish  1018 VMAYLFITLNAFQGLYIFLVYAVYNSEVRNAIRRIQEKRKALSFTNCSQPISFLPSQKSPRASWV 1082

Human   972 -PLQTRRDR 979
             .|||...|
Zfish  1083 HSLQTHSSR 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADGRD2	NP_001382354.1	CLECT	50..>73	CDD:153057	6/16 (38%)
		LamG	111..297	CDD:473984	68/194 (35%)
		GPS	<647..679	CDD:460350	16/31 (52%)
		7tmB2_GPR144	692..954	CDD:320383	143/261 (55%)
		TM helix 1	694..719	CDD:320383	13/24 (54%)
		TM helix 2	728..750	CDD:320383	11/21 (52%)
		TM helix 3	759..786	CDD:320383	16/26 (62%)
		TM helix 4	798..818	CDD:320383	12/19 (63%)
		TM helix 5	835..864	CDD:320383	16/28 (57%)
		TM helix 6	888..915	CDD:320383	18/26 (69%)
		TM helix 7	917..942	CDD:320383	14/24 (58%)
adgrd2	XP_021334184.1	LamG	204..402	CDD:473984	71/200 (36%)
		GPS	735..779	CDD:460350	17/43 (40%)
		7tmB2_GPR144	792..1054	CDD:320383	143/261 (55%)
		TM helix 1	794..819	CDD:320383	13/24 (54%)
		TM helix 2	828..850	CDD:320383	11/21 (52%)
		TM helix 3	859..886	CDD:320383	16/26 (62%)
		TM helix 4	898..918	CDD:320383	12/19 (63%)
		TM helix 5	935..964	CDD:320383	16/28 (57%)
		TM helix 6	988..1015	CDD:320383	18/26 (69%)
		TM helix 7	1017..1042	CDD:320383	14/24 (58%)