DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADGRD2 and Adgrl2

DIOPT Version :9

Sequence 1:	NP_001382354.1	Gene:	ADGRD2 / 347088	HGNCID:	18651	Length:	982	Species:	Homo sapiens
Sequence 2:	NP_599235.3	Gene:	Adgrl2 / 171447	RGDID:	620835	Length:	1487	Species:	Rattus norvegicus

Alignment Length:	1034	Identity:	229/1034 - (22%)
Similarity:	372/1034 - (35%)	Gaps:	247/1034 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   105 RARTTAVLVFDERTADRAARLRSPLPELAALTACTHVQWDCASP-------------DPAALFSV 156
            :.||..::.||.||     |::|      ......:..:...||             |...|:.:
  Rat   227 KERTRNIVKFDLRT-----RIKS------GEAIINYANYHDTSPYRWGGKTDIDLAVDENGLWVI 280

Human   157 AAPALPNALQLRAFAEPGGVVRAALVVRGQHAPFLAAFRADGRWHHVCATWEQRGGRWA------ 215
            .|....|                .::|..|..|:...|.|  .|.   .|:::|....|
  Rat   281 YATEQNN----------------GMIVISQLNPYTLRFEA--TWE---TTYDKRAASNAFMICGV 324

Human   216 ------LFSDGRRRAG------------ARGLGAGHPVPSGGILVLGQDQDS-------LGGGFS 255
                  ::.|....||            :||.....|.|:....:...|.:.       ....|.
  Rat   325 LYVVRSVYQDNESEAGKNVIDYIYNTRLSRGEHVDVPFPNQYQYIAAVDYNPRDNQLYVWNNNFI 389

Human   256 VRHALSGNLTDFHLWARALSPAQLHR----------------------------ARACAPPSEGL 292
            :|::|.....|         |||:..                            :...|.|.||.
  Rat   390 LRYSLEFGPPD---------PAQVPTTAVTITSSAELFKTTVSTTSSTSQRGPVSSTVAGPQEGS 445

Human   293 LFRWDPGALDVTPSLLPTVWVRLLCPVPSEECPT-------WNPGPRSEGSELCLEPQP------ 344
            .....|.|:..|.  :|.  |..:.|:|...|..       |   |:::...:...|.|
  Rat   446 RGTKPPPAVSTTK--IPP--VTNIFPLPERFCEALEMKGIKW---PQTQRGMMVERPCPKGTRGT 503

Human   345 --FLCCYRTEPYR----RLQDAQS-WP---GQDVISRVNA--LANDIVLLPDPLSEVHGALSPAE 397
              :||...|..:.    .|.:..| |.   .|.:.|..||  |||::.      ....|.:...:
  Rat   504 ASYLCMASTGTWNPKGPDLSNCTSHWVNQLAQKIRSGENAASLANELA------KHTKGTVFAGD 562

Human   398 ASSFLGLLEH---VLAMEMAPLGP----AALLAVVRFLKRVVALGAGDPELLLTGPWEQLSQGVV 455
            .||.:.|:|.   :|..::..|.|    :|..:..:..||.....|             ..:.:|
  Rat   563 VSSSVRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQKREKTCRA-------------YLKAIV 614

Human   456 SVASLVLEEQVADTW--LSLREVIGGPMALVASVQRLAPLLSTSMTSERPRMRIQHRHAGLEVRS 518
            .....:|..:..|.|  ::..|.......|:.:::..|.:|:.::. |..|:.:...:..|||..
  Rat   615 DTVDNLLRAETLDCWKHMNSSEQAHTATMLLDTLEEGAFVLADNLL-EPTRVSMPTDNIVLEVAV 678

Human   519 LRLREASTRGCL--FTMPGGRPEGPGHIHIPASEVRRLLRKGLSGVTVIHSWFTSRVFQHTLEGP 581
            |     ||.|.:  ||...|.......|.:.|:.|::..|.||:.|..|       :::..  ||
  Rat   679 L-----STEGQVQDFTFHLGFKGAFSSIQLSANTVKQNSRNGLAKVVFI-------IYRSL--GP 729

Human   582 DLEPQAPASSEEANRVQRFLSTQVGSAIISSEVWDVTGEVNVA--MTFHLQHRAQSPLFPPHPP- 643
            .|..:.......|:.:.|..:..|.|.::|..:...:..|.:.  :.|.:.|......|..:..
  Rat   730 FLSTENATVKLGADLLGRNSTIAVNSHVLSVSINKESSRVYLTDPVLFSMPHIDSDNYFNANCSF 794

Human   644 ---SPYT-GGAWATTGCSVAALYLDSTACFCNHSTSFAILLQIYE-VQRGPEEESLLRTLSFVGC 703
               |..| .|.|:|.||.:.......|.|.|:|.|:||||:...| |.:....:.||..:::||.
  Rat   795 WNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIVYKDGVHKLLLTVITWVGI 859

Human   704 GVSFCALTTTFLLFLVAGVPKSERTTVHKNLTFSLASAEGFLMTSEWAKANEVACVAVTVAMHFL 768
            .||...|......|......:|:|.|:||||..:|..||...:.........:||......:||.
  Rat   860 VVSLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIGIDKTQYTIACPVFAGLLHFF 924

Human   769 FLVAFSWMLVEGLLLWRKVVAVSMHPGPGMRLYHATGWGVPVGIVAVTLAMLPHDYVAPG---HC 830
            ||.|||||.:||:.|:..:|.|........:.|:..|:..|..:|.|:.|:   ||.:.|   .|
  Rat   925 FLAAFSWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAI---DYKSYGTLEAC 986

Human   831 WLNVHTNAIWAFVGPVLFVLTANTCILARVVMITVSSARRRARMLSPQPCLQQQI---------- 885
            ||:|....||:|:|||.|::..|...|    :||:....:.:..|.|.....:.|
  Rat   987 WLHVDNYFIWSFIGPVTFIILLNIIFL----VITLCKMVKHSNTLKPDSSRLENINNYRVCDGYY 1047

Human   886 ------------WTQIWATVKPVLVLLPVLGLTWLAGILV--HLSPAWAYAAVGLNSIQGLYIFL 936
                        :.:.|  |.....||.:|||||..|:|.  ..:...||.....|:.|||:||:
  Rat  1048 NTDLPGYEDNKPFIKSW--VLGAFALLCLLGLTWSFGLLFVNEETVVMAYLFTAFNAFQGLFIFI 1110

Human   937 VYAACNEEVRSALQRMAEKKVAEGPMALELP-------------QHSPPLQTRRDRLWN 982
            .:.|..::||....:........|.:..|.|             ::|...|:|..|:||
  Rat  1111 FHCALQKKVRKEYAKCFRHWYCCGGLPTESPHSSVKASTSRTSARYSSGTQSRIRRMWN 1169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADGRD2	NP_001382354.1	None
Adgrl2	NP_599235.3	Gal_Lectin	49..129	CDD:396628
		OLF	142..398	CDD:413369	34/202 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..462		8/43 (19%)
		HormR	469..533	CDD:214468	12/66 (18%)
		GAIN	542..764	CDD:406802	53/255 (21%)
		GPS	788..840	CDD:197639	17/51 (33%)
		7tm_GPCRs	848..1129	CDD:421689	83/289 (29%)
		TM helix 1	850..875	CDD:410628	8/24 (33%)
		TM helix 2	884..906	CDD:410628	8/21 (38%)
		TM helix 3	915..942	CDD:410628	12/26 (46%)
		TM helix 4	954..974	CDD:410628	5/19 (26%)
		TM helix 5	991..1020	CDD:410628	11/32 (34%)
		TM helix 6	1036..1087	CDD:410628	12/52 (23%)
		TM helix 7	1091..1116	CDD:410628	9/24 (38%)
		Latrophilin	1128..1487	CDD:396778	9/42 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1139..1160		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1386..1428
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191130at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820