Protein Alignment ADGRD2 and Adgrd2

DIOPT Version :10

• Sequence 1: NP_001382354.1
• Gene: ADGRD2 / 347088
• HGNCID: 18651
• Length: 982
• Species: Homo sapiens
• Sequence 2: XP_063141212.1
• Gene: Adgrd2 / 134486217
• RGDID: 402289764
• Length: 1084
• Species: Rattus norvegicus
• Alignment Length: 946
• Identity: 588/946 - (62%)
• Similarity: 674/946 - (71%)
• Gaps: 64/946 - (6%)

Human    31 WAPAPVAAGEVVKTAGGVCKFSGQRLSWWQAQESCEQQFGHLALQPPDGVLASRLRDPVWVGQRE 95
            |..||...     ||..:|:|:||||:||||||||:|:||||||.|||..|.|.|.:.|||||||
  Rat   171 WRTAPEKL-----TAEELCEFTGQRLNWWQAQESCDQRFGHLALGPPDRTLTSHLPNSVWVGQRE 230

Human    96 APLRRPPQRRARTTAVLVFDERTADRAARLRSPLPELAALTACTHVQWDCASPDPAALFSVAAPA 160
            .||:..||||..|||.|||.|.||.|||||...||.|||||||.|||||.|:.:.|.|||:|.||
  Rat   231 DPLQSQPQRRDHTTAALVFQEMTAGRAARLLEVLPALAALTACAHVQWDMAATEVATLFSLATPA 295

Human   161 LPNALQLRAFAEPGGVVRAALVVRGQHAPFLAAFRADGRWHHVCATWEQRGGRWALFSDGRRRAG 225
            :.|||||||||||.|.|.|.||| |..|||.|.||:|..||||||||| ..||||||::.||.||
  Rat   296 VANALQLRAFAEPRGSVHAVLVVXGHQAPFNAVFRSDSCWHHVCATWEXYSGRWALFTNRRRCAG 360

Human   226 ARGLGAGHPVPSGGILVLGQDQDSLGGGFSVRHALSGNLTDFHLWARALSPAQLHRARACAPPSE 290
            |:||..|.|||..|:|||||||||||||||.|     .|||||||...||..|:.||.| |||.
  Rat   361 AQGLSVGQPVPPDGVLVLGQDQDSLGGGFSAR----XTLTDFHLWDPVLSLQQVRRAHAXAPPPX 421

Human   291 GLLFRWDPGALDVTPSLLPTVWVRLLCPVPSEECPTWNPGPRSEGSELCLEPQPFLCCYRTEPYR 355
            ||||:|||.||:|||:|||||.:.||||||||:||. ||||.::|||.||.|||.||||..|.|:
  Rat   422 GLLFQWDPEALNVTPTLLPTVLLSLLCPVPSEQCPRXNPGPGTKGSEFCLYPQPSLCCYPKETYQ 486

Human   356 RLQDAQSWPGQDVISRVNALANDIVLLPDPLSEVHGALSPAEASSFLGLLEHVLAMEMAPLGPAA 420
            :|||.|:||.|:::|||||||:..||:|.||||....||..:|||||.|||.|:|.:..||||..
  Rat   487 QLQDFQTWPDQNILSRVNALASATVLVPSPLSEAPRILSLDKASSFLCLLERVMAEKPGPLGPVT 551

Human   421 LLAVVRFLKRVVALGAGDPELLLTGPWEQLSQGVVSVASLVLEEQVADTWLSLREVIGGPMALVA 485
            |||::.||:||.||....|| |||.|||:|.:|.||||||.||||.|..||::.||:|||:|||.
  Rat   552 LLAMLHFLRRVTALRVEQPE-LLTQPWEELDRGFVSVASLTLEEQSASVWLAVNEVVGGPVALVM 615

Human   486 SVQRLAPLLSTSMTSERPRMRIQHRHAGLEVRSLRLREASTRGCLFTMPGGRPEGPGHIHIPASE 550
            ||||||.|||:.:||.:||:.|:|..|.||||||.||.| ..|  . :||..|:|||||.|||:.
  Rat   616 SVQRLASLLSSMLTSAQPRIGIKHHLASLEVRSLHLRSA-LEG--IXIPGEHPDGPGHIRIPAAP 677

Human   551 VRRLLRKGLSGVTVIHSWFTSRVFQHTLEGPDLEPQAPASSEEANRVQRFLSTQVGSAIISSEVW 615
                  :...|    |...|||:|||||.|..||.||...|::. ||||.||||||||::|||||
  Rat   678 ------RESHG----HHTITSRIFQHTLGGSGLEFQADNGSKDI-RVQRSLSTQVGSALLSSEVW 731

Human   616 DVT-GEVNVAMTFHLQHRAQ-----SPLFPPHPPSPY-----------TGGAWATTGCSVAALYL 663
            |.| ||::.|:||||||:||     :.:||.....|.           .||:||||||. |.::.
  Rat   732 DNTAGELDTAVTFHLQHQAQALGGAALVFPQKILEPVCAFWDFSVSSDAGGSWATTGCLXAPVHP 796

Human   664 DSTACFCNHSTSFAILLQIYEVQRGPEEESLLRTLSFVGCGVSFCALTTTFLLFLVAGVPKSERT 728
            |||.|.||||||.|||||:||||.||.||||||||||||||||.|||.||||||:.||.|.|:||
  Rat   797 DSTTCPCNHSTSLAILLQVYEVQGGPGEESLLRTLSFVGCGVSLCALATTFLLFVAAGAPTSKRT 861

Human   729 TVHKNLTFSLASAEGFLMTSEWAKANEVACVAVTVAMHFLFLVAFSWMLVEGLLLWRKVVAVSMH 793
            |:||||..||||||||||||||.|.|:|.|||||.|||.||||||||   :|       ||||||
  Rat   862 TIHKNLILSLASAEGFLMTSEWVKTNKVTCVAVTAAMHLLFLVAFSW--XQG-------VAVSMH 917

Human   794 PGPGMRLYHATGWGVPVGIVAVTLAMLPHDYVAPGHCWLNVHTNAIWAFVGPVLFVLTANTCILA 858
            |||.||||.|..||:||.|||:|||:..||||..|||||:|.|:||||||||||.||||||.||.
  Rat   918 PGPRMRLYCAACWGIPVVIVAITLALHTHDYVTSGHCWLSVCTDAIWAFVGPVLLVLTANTYILV 982

Human   859 RVVMITVSSARRRARMLSPQPCLQQQIWTQIWATVKPVLVLLPVLGLTWLAGILVHLSPAWAYAA 923
            |||.:.|||.||.|||||.||.|.|:|.. :||.|||||.||||||||||.|:|||:||.|||||
  Rat   983 RVVTVIVSSTRRHARMLSLQPDLHQKIRFXMWAMVKPVLALLPVLGLTWLLGLLVHISPTWAYAA 1047

Human   924 VGLNSIQGLYIFLVYAACNEEVRSALQRMAEKKVAE 959
            |.|||.|              |::|||||.|||.||
  Rat  1048 VLLNSFQ--------------VQNALQRMTEKKAAE 1069

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADGRD2	NP_001382354.1	CLECT	50..>73	CDD:153057	17/22 (77%)
		LamG	111..297	CDD:473984	121/185 (65%)
		GPS	<647..679	CDD:460350	20/31 (65%)
		7tmB2_GPR144	692..954	CDD:320383	179/261 (69%)
		TM helix 1	694..719	CDD:320383	22/24 (92%)
		TM helix 2	728..750	CDD:320383	18/21 (86%)
		TM helix 3	759..786	CDD:320383	16/26 (62%)
		TM helix 4	798..818	CDD:320383	13/19 (68%)
		TM helix 5	835..864	CDD:320383	22/28 (79%)
		TM helix 6	888..915	CDD:320383	20/26 (77%)
		TM helix 7	917..942	CDD:320383	11/24 (46%)
Adgrd2	XP_063141212.1	None