DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sirt1 and Sirt1

DIOPT Version :10

Sequence 1:NP_477351.1 Gene:Sirt1 / 34708 FlyBaseID:FBgn0024291 Length:823 Species:Drosophila melanogaster
Sequence 2:NP_062786.1 Gene:Sirt1 / 93759 MGIID:2135607 Length:737 Species:Mus musculus


Alignment Length:752 Identity:296/752 - (39%)
Similarity:395/752 - (52%) Gaps:156/752 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 AEAEAEATATTTEPAT--SELAG-KANGEIKTKTLAAREEQEIGANLEHKTKNPTKSMGEDEDDE 109
            |.|..|| |:...||.  .|.|| .|:.|.:....|...:.:.|:.|..:.:     ..:|.||:
Mouse    57 AAAGCEA-ASAAAPAALWREAAGAAASAEREAPATAVAGDGDNGSGLRREPR-----AADDFDDD 115

  Fly   110 EEEEEDDEEEE--------EDD--------EEGITGTSNEDEDSSSNCSSSVEPDWKLR------ 152
            |.||||:....        .|:        ..|.....::|:|.:|:.|||   ||..|      
Mouse   116 EGEEEDEAAAAAAAAAIGYRDNLLLTDGLLTNGFHSCESDDDDRTSHASSS---DWTPRPRIGPY 177

  Fly   153 -WLQREFYTGRVPRQVIASIMPHFATGLAGDTDDSVLWDYLAHLLNEPKRRNKLASVNTFDDVIS 216
             ::|:....|..||.::..::|.  |....:.||..||..:.::|:||.:|.|...:||.:|.:.
Mouse   178 TFVQQHLMIGTDPRTILKDLLPE--TIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVK 240

  Fly   217 LVKKSQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDFPDLPDPQAMFDINYFKRDPRPFYKFA 281
            |:::.:|||||||||||||||||||||.:|||||||.||||||||||||||.||::|||||:|||
Mouse   241 LLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFA 305

  Fly   282 REIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGIQRVIECHGSFSTASCTKCRFKC 346
            :|||||:||||.||:||.:.:.:|||||||||||||||:||||||:::|||||:||||..|::|.
Mouse   306 KEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRILQCHGSFATASCLICKYKV 370

  Fly   347 NADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHT 411
            :.:|:|.|||.|.:|.||:|.             .:|.|      .||||:||||||.||:::|.
Mouse   371 DCEAVRGDIFNQVVPRCPRCP-------------ADEPL------AIMKPEIVFFGENLPEQFHR 416

  Fly   412 VMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQILINREQLHHLKFDVELLGDSDVIINQI 476
            .|..|||..||||||||||||||||.||||||..|||||||||.|.||.||||||||.|||||::
Mouse   417 AMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINEL 481

  Fly   477 CHRLSDNDDCWRQLCCDESVLTESKELMP-PEHSNHHLHH---HLLHHRHCSSESERQSQLDTDT 537
            ||||...   :.:|||:...|:|..|..| |:....||..   ..||....||..||        
Mouse   482 CHRLGGE---YAKLCCNPVKLSEITEKPPRPQKELVHLSELPPTPLHISEDSSSPER-------- 535

  Fly   538 QSIKSNSSADYILGSAGTCSD-SGFESSTFSCGKRSTAAEAAAIERIKTDILVELNETTALSCDR 601
             ::..:||....|....|.:: :..|.|..||                    ||           
Mouse   536 -TVPQDSSVIATLVDQATNNNVNDLEVSESSC--------------------VE----------- 568

  Fly   602 LGLEGPQTTVESYRHLSIDSSKDSGIEQCDNEATPSYVRPSNLVQETKTVAPSLTPIPQQRGKRQ 666
               |.|| .|::.|::     ::..:|..|.:|..|.....|   |..:||.::......|..::
Mouse   569 ---EKPQ-EVQTSRNV-----ENINVENPDFKAVGSSTADKN---ERTSVAETVRKCWPNRLAKE 621

  Fly   667 TAAERLQPGTFYSHTNNYSYVFPGAQVFWDNDYSDDDDEEEERSHNRHSDLFGNVGHNYKDDDED 731
            ..::||: |..|.......|:|.||:|     |||.:|:....|         :.|.|   .|..
Mouse   622 QISKRLE-GNQYLFVPPNRYIFHGAEV-----YSDSEDDVLSSS---------SCGSN---SDSG 668

  Fly   732 ACDLNAVPLSPLLPPSLEAHIVTDIVNGSNEPLPNSS 768
            .|.          .||||            |||.:.|
Mouse   669 TCQ----------SPSLE------------EPLEDES 683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sirt1NP_477351.1 SIRT1 222..476 CDD:238699 173/253 (68%)
Sirt1NP_062786.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..56
Interaction with H1-4. /evidence=ECO:0000250|UniProtKB:Q96EB6 2..268 85/236 (36%)
Interaction with CLOCK. /evidence=ECO:0000269|PubMed:18662547 2..131 23/84 (27%)
Nuclear localization signal 32..39
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 75..125 14/50 (28%)
Interaction with CCAR2. /evidence=ECO:0000250|UniProtKB:Q96EB6 135..533 218/408 (53%)
Nuclear export signal 138..145 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 152..171 6/25 (24%)
Nuclear localization signal 223..230 1/6 (17%)
SIRT1 246..481 CDD:238699 155/234 (66%)
Required for interaction with the sumoylated form of CCAR2. /evidence=ECO:0000250|UniProtKB:Q96EB6 248..251 2/2 (100%)
Nuclear export signal 425..431 3/5 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 514..539 9/28 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 653..713 16/59 (27%)
Blue background indicates that the domain is not in the aligned region.

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