Protein Alignment Sirt1 and HST2

DIOPT Version :9

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_015310.1
• Gene: HST2 / 856092
• SGDID: S000005936
• Length: 357
• Species: Saccharomyces cerevisiae
• Alignment Length: 377
• Identity: 125/377 - (33%)
• Similarity: 181/377 - (48%)
• Gaps: 64/377 - (16%)

  Fly   207 SVNTFDDVISLVK-----KSQ---KIIVLTGAGVSVSCGIPDFRST-NGIYARLAHDFPDLPDPQ 262
            ||:|....:|:.|     ||.   |:|.:.|||:|.|||||||||. .|:|..||.  ..||.|:
Yeast     2 SVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLAR--LKLPYPE 64

  Fly   263 AMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGIQ-- 325
            |:||:::|:.||.|||..|:|:|||.|:||..|..:|:.:.|..|.|.||||||||||.||::
Yeast    65 AVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDD 129

  Fly   326 RVIECHGSFSTASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVE 390
            .:||.||||:...|..|              .:..|  ||...:|         :.|..::..|:
Yeast   130 LIIEAHGSFAHCHCIGC--------------GKVYP--PQVFKSK---------LAEHPIKDFVK 169

  Fly   391 ----NGIMKPDIVFFGEGLPDEYHTVMATDKDVC-------------DLLIVIGSSLKVRPVAHI 438
                ..::||.||||||.|||.:......|.:..             .|:||:|:||.|.|.|.:
Yeast   170 CDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASL 234

  Fly   439 PSSIPATVPQILINREQLHHLK-----FDVELLGDSDVIINQICHRLSDNDDCWRQLCCDESVLT 498
            |..||..|.::|.|.|.:...|     .|:.:...||....|:...|...:|..:.|.....:..
Yeast   235 PEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGD 299

  Fly   499 ESKE-LMPPEHSNHHLHHHLLHHRHCSSESERQSQL---DTDTQSIKSNSSA 546
            .||| |:...|...:|......|.....:.::..:|   |:|.....::||:
Yeast   300 NSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSS 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	DUF592	<202..228	CDD:282439	9/28 (32%)
		SIRT1	222..476	CDD:238699	102/281 (36%)
HST2	NP_015310.1	SIRT1	26..277	CDD:238699	102/277 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R577
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840