Protein Alignment Sirt1 and HST4

DIOPT Version :9

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_010477.3
• Gene: HST4 / 851772
• SGDID: S000002599
• Length: 370
• Species: Saccharomyces cerevisiae
• Alignment Length: 388
• Identity: 98/388 - (25%)
• Similarity: 168/388 - (43%)
• Gaps: 88/388 - (22%)

  Fly   130 TSNEDEDSSSNCSSSVEPDWKLRWLQREFYTGRVPRQVIASIMPHFATGLAGDTDDSVLWDYLAH 194
            |:.:...:.:.|:.:::|...|..|::. ...|.||   .|..|..          :.::|..|:
Yeast    14 TAEKKPQTENRCNENLKPRRLLPQLKKS-VRNRKPR---LSYRPEL----------NSVFDLDAY 64

  Fly   195 L----LNEPKRRNKLASVNTFDDVISLVKKSQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDF 255
            :    |::.:|.:...........::.   |::::|::|||:||:.|||||||:.||::.:
Yeast    65 VDSTHLSKSQRHHMDRDAGFISYALNY---SKRMVVVSGAGISVAAGIPDFRSSEGIFSTV---- 122

  Fly   256 PDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEF------QPSPCHRFIKMLETKGKLLRNYTQN 314
             :....:.:||.|....|.....|| .::....|      ||:..|..:......|:|||.||||
Yeast   123 -NGGSGKDLFDYNRVYGDESMSLKF-NQLMVSLFRLSKNCQPTKFHEMLNEFARDGRLLRLYTQN 185

  Fly   315 IDTLER-----------VAGIQRVIECHGSFSTASCTKC---------RFKCNADALRADIFAQR 359
            ||.|:.           ...|...::.|||.....|.||         .|||:      |.|..|
Yeast   186 IDGLDTQLPHLSTNVPLAKPIPSTVQLHGSIKHMECNKCLNIKPFDPELFKCD------DKFDSR 244

  Fly   360 ---IPVCPQCQPNKEQSVDASVAVTEEELRQLVENGI--MKPDIVFFGEGLPD-EYHTVMATD-- 416
               ||.||||:..:          |..::..|...|:  ::|.::.:.|..|: ::...:|.:
Yeast   245 TEIIPSCPQCEEYE----------TVRKMAGLRSTGVGKLRPRVILYNEVHPEGDFIGEIANNDL 299

  Fly   417 KDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQ-----ILIN-----REQLHHLKF-DVELLGD 468
            |...|.||::|:|||:..|.:|.....|.|..     :.:|     :..|..||| |:.:|||
Yeast   300 KKRIDCLIIVGTSLKIPGVKNICRQFAAKVHANRGIVLYLNTSMPPKNVLDSLKFVDLVVLGD 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	DUF592	<202..228	CDD:282439	2/25 (8%)
		SIRT1	222..476	CDD:238699	83/292 (28%)
HST4	NP_010477.3	SIR2	77..370	CDD:223915	84/311 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810