DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt1 and SIR2

DIOPT Version :9

Sequence 1:	NP_477351.1	Gene:	Sirt1 / 34708	FlyBaseID:	FBgn0024291	Length:	823	Species:	Drosophila melanogaster
Sequence 2:	NP_010242.1	Gene:	SIR2 / 851520	SGDID:	S000002200	Length:	562	Species:	Saccharomyces cerevisiae

Alignment Length:	291	Identity:	128/291 - (43%)
Similarity:	176/291 - (60%)	Gaps:	15/291 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 RNKLASVNTFDDVISLVKKSQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDFPDLPDPQAMFD 266
            |.:|::..|.|..|..:..::||:||||||||.|.|||||||:.|.|:::.|  ..|.|||.:|:
Yeast   235 RLRLSNFFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKH--LGLDDPQDVFN 297

  Fly   267 INYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGI--QRVIE 329
            .|.|..||..||..|..:.|.|...||.|.|||||:.|||||||||||||.||..|||  .::::
Yeast   298 YNIFMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQ 362

  Fly   330 CHGSFSTASCTKCRFKCNADALRADIFAQRIPVCPQCQP----------NKEQSVDASVAVTEEE 384
            |||||:||:|..|.:....:.:...|....:|:||.|..          |.:..|.||.....|.
Yeast   363 CHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAASQGSMSER 427

  Fly   385 LRQLVEN-GIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQ 448
            ...::.: |::||||.||||.||:::|..:..|...|||||.||:||||.||:.|.:.:|:.|||
Yeast   428 PPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQ 492

  Fly   449 ILINREQLHHLKFDVELLGDSDVIINQICHR 479
            :||||:.:.|.:||:.|||..|.|...:..:
Yeast   493 VLINRDPVKHAEFDLSLLGYCDDIAAMVAQK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	DUF592	<202..228	CDD:282439	8/25 (32%)
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	123/266 (46%)
SIR2	NP_010242.1	DUF592	104..261	CDD:368003	8/25 (32%)
SIR2	NP_010242.1	SIRT1	255..517	CDD:238699	122/263 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346701
Domainoid	1	1.000	185	1.000	Domainoid score	I677
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1880
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	1	1.000	-	-		otm46781
orthoMCL	1	0.900	-	-		OOG6_103854
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R577
SonicParanoid	1	1.000	-	-		X3771
TreeFam	0	0.000	Not matched by this tool.
	11	10.720