Protein Alignment Sirt1 and sirt4

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_001005988.1
• Gene: sirt4 / 791628
• ZFINID: ZDB-GENE-041010-65
• Length: 310
• Species: Danio rerio
• Alignment Length: 267
• Identity: 69/267 - (25%)
• Similarity: 106/267 - (39%)
• Gaps: 86/267 - (32%)

  Fly   209 NTFDDVISLVKKSQKIIVLTGAGVSVSCGIPDFRSTN-GIYAR-----LAHDFPDLPDPQAMFDI 267
            :..:.:.:.:.::.::.|::|||:|...||||:||.. |:|||     :.|
Zfish    38 SALEQLQAFISQASRLFVISGAGLSTESGIPDYRSEGVGLYARTNRRPMQH-------------- 88

  Fly   268 NYFKRDPRPFYKFAREIYPG-----EFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGIQRV 327
            :.|.|..:...::....|.|     ..||:..|..::..|.||||....|||:|.|...||.||:
Zfish    89 SEFVRSEKSRQRYWARNYVGWPQFSSHQPNSAHLALRDWEEKGKLHWLVTQNVDALHLKAGQQRL 153

  Fly   328 IECHGSFSTASCTKC-----------RF----------KCNADALRADIFAQ-------RIPVCP 364
            .|.|||.....|..|           ||          .| |.|...|:|.:       |:|.|.
Zfish   154 TELHGSTHRVVCLDCGELTPRAELQKRFTALNPGWEATAC-AVAPDGDVFLEEEQVLNFRVPACN 217

  Fly   365 QCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDE----YHTVMATDKDVCDLLIV 425
            .|                        .|::||::.|||:.:...    .|..:|..    |.::|
Zfish   218 AC------------------------GGVLKPEVTFFGDVVNRNTVHFVHNKLAES----DAVLV 254

  Fly   426 IGSSLKV 432
            .||||:|
Zfish   255 AGSSLQV 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	69/254 (27%)
sirt4	NP_001005988.1	SIRT4	43..304	CDD:238700	69/262 (26%)